DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3436 and CDC4

DIOPT Version :9

Sequence 1:	NP_001285543.1	Gene:	CG3436 / 33180	FlyBaseID:	FBgn0031229	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_116585.1	Gene:	CDC4 / 850539	SGDID:	S000001885	Length:	779	Species:	Saccharomyces cerevisiae

Alignment Length:	334	Identity:	88/334 - (26%)
Similarity:	147/334 - (44%)	Gaps:	63/334 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LEGHEGEIFTA-EFHPEGELLLSSGFDRQIYIWQVYEDCEN--VMAMSGHSGAVMEAHFTPDGSH 112
            |.||...:.|. :|  |...:::...|:.|   :||:....  ::.:|||.|.|....:. .|..
Yeast   377 LRGHMTSVITCLQF--EDNYVITGADDKMI---RVYDSINKKFLLQLSGHDGGVWALKYA-HGGI 435

  Fly   113 IFTCSTDKTLAFWDIATGQRQRRFKGHGNFVNSVQ-GSRRGQQLLCSGSDDRTIKIWDARKKHAA 176
            :.:.|||:|:..|||..|.....||||.:.|..:. ...:..:.:.:||.|.|:.:|...|:.:.
Yeast   436 LVSGSTDRTVRVWDIKKGCCTHVFKGHNSTVRCLDIVEYKNIKYIVTGSRDNTLHVWKLPKESSV 500

  Fly   177 -------------HT-LESPFQVTAV--------CFGDTGEQVISGGIDNEVKIWDIRKQAVLHH 219
                         || .|:|:.|..:        .....|..|:||..||.:.:||:.:...|:.
Yeast   501 PDHGEEHDYPLVFHTPEENPYFVGVLRGHMASVRTVSGHGNIVVSGSYDNTLIVWDVAQMKCLYI 565

  Fly   220 LRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDVR--------PYAPGER--CVKV------FQG 268
            |.||:|.|.......|....::.:||.|:|:||:.        .||....  |.|:      .||
Yeast   566 LSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIWNNGECSYATNSASPCAKILGAMYTLQG 630

  Fly   269 HQHNFEKNLLRCAWSPGSDK-ITSGSADRHVYIWDVN--TRRILYKLPGHNGSVNAV-DFSPKEP 329
              |.....|||.     ||| :.|.:||..:..||.|  :|:..|    |:.:::|: .|...:.
Yeast   631 --HTALVGLLRL-----SDKFLVSAAADGSIRGWDANDYSRKFSY----HHTNLSAITTFYVSDN 684

  Fly   330 LILSGSSDK 338
            :::|||.::
Yeast   685 ILVSGSENQ 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3436	NP_001285543.1	WD40	<19..346	CDD:225201	88/334 (26%)
		WD40	50..342	CDD:238121	88/334 (26%)
		WD40 repeat	58..96	CDD:293791	7/40 (18%)
		WD40 repeat	102..138	CDD:293791	10/35 (29%)
		WD40 repeat	143..180	CDD:293791	9/51 (18%)
		WD40 repeat	186..221	CDD:293791	9/42 (21%)
		WD40 repeat	227..267	CDD:293791	12/55 (22%)
		WD40 repeat	277..313	CDD:293791	14/38 (37%)
		WD40 repeat	319..342	CDD:293791	5/21 (24%)
CDC4	NP_116585.1	CDC4_D	228..272	CDD:407099
		F-box-like	275..319	CDD:403981
		WD40	374..693	CDD:238121	88/332 (27%)
		WD40 repeat	385..420	CDD:293791	7/39 (18%)
		WD40 repeat	426..461	CDD:293791	10/35 (29%)
		WD40 repeat	466..527	CDD:293791	12/60 (20%)
		WD40 repeat	534..567	CDD:293791	9/32 (28%)
		WD40 repeat	573..629	CDD:293791	12/55 (22%)
		WD40 repeat	637..667	CDD:293791	13/34 (38%)
		WD40 repeat	716..751	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7467
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950