DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3436 and Snrnp40

DIOPT Version :9

Sequence 1:	NP_001285543.1	Gene:	CG3436 / 33180	FlyBaseID:	FBgn0031229	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_079921.2	Gene:	Snrnp40 / 66585	MGIID:	1913835	Length:	358	Species:	Mus musculus

Alignment Length:	352	Identity:	199/352 - (56%)
Similarity:	257/352 - (73%)	Gaps:	22/352 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KRPNNSVILA----------QEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAPIMQLEGHEGEI 58
            |||.:.::|.          |:|...            |||::|..|.|:||||||.|.|||||:
Mouse    18 KRPRHELLLGAAGAGPGAGPQQATPG------------ALLQAGPPRCSSLQAPIMLLSGHEGEV 70

  Fly    59 FTAEFHPEGELLLSSGFDRQIYIWQVYEDCENVMAMSGHSGAVMEAHFTPDGSHIFTCSTDKTLA 123
            :..:|||.|..|.|:||||.|.:|.||.||:|...:.||||||||.|:..|||.:|:.|||||:|
Mouse    71 YCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVA 135

  Fly   124 FWDIATGQRQRRFKGHGNFVNSVQGSRRGQQLLCSGSDDRTIKIWDARKKHAAHTLESPFQVTAV 188
            .||..||:|.:|.|||.:||||...:|||.||:|:||||.|:|:||.|||.|..|.::.:||.||
Mouse   136 VWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAVQTFQNTYQVLAV 200

  Fly   189 CFGDTGEQVISGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDV 253
            .|.||.:|:|||||||::|:||:|:..:.:.:|||:|::||:|||.||.::|:||||||:|||||
Mouse   201 TFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDV 265

  Fly   254 RPYAPGERCVKVFQGHQHNFEKNLLRCAWSPGSDKITSGSADRHVYIWDVNTRRILYKLPGHNGS 318
            ||:||.|||||:|||:.||||||||||:|||...||.:|||||.||:||..:||:|||||||.||
Mouse   266 RPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRVLYKLPGHAGS 330

  Fly   319 VNAVDFSPKEPLILSGSSDKTLYLGEI 345
            :|.|.|.|.||:|||.||||.||:|||
Mouse   331 INEVAFHPDEPIILSASSDKRLYMGEI 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3436	NP_001285543.1	WD40	<19..346	CDD:225201	193/327 (59%)
		WD40	50..342	CDD:238121	177/291 (61%)
		WD40 repeat	58..96	CDD:293791	17/37 (46%)
		WD40 repeat	102..138	CDD:293791	19/35 (54%)
		WD40 repeat	143..180	CDD:293791	22/36 (61%)
		WD40 repeat	186..221	CDD:293791	17/34 (50%)
		WD40 repeat	227..267	CDD:293791	28/39 (72%)
		WD40 repeat	277..313	CDD:293791	23/35 (66%)
		WD40 repeat	319..342	CDD:293791	14/22 (64%)
Snrnp40	NP_079921.2	WD40	63..352	CDD:238121	176/288 (61%)
		WD 1	65..104		22/38 (58%)
		WD40 repeat	71..108	CDD:293791	17/36 (47%)
		WD 2	108..147		24/38 (63%)
		WD40 repeat	113..149	CDD:293791	20/35 (57%)
		WD 3	150..190		24/39 (62%)
		WD40 repeat	156..191	CDD:293791	20/34 (59%)
		WD 4	192..231		19/38 (50%)
		WD40 repeat	197..233	CDD:293791	18/35 (51%)
		WD 5	234..273		26/38 (68%)
		WD40 repeat	239..279	CDD:293791	28/39 (72%)
		WD 6	284..323		26/38 (68%)
		WD40 repeat	289..313	CDD:293791	16/23 (70%)
		WD 7	326..358		22/32 (69%)
		WD40 repeat	331..353	CDD:293791	13/21 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3538
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1703
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54559
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004893
OrthoInspector	1	1.000	-	-		oto95174
orthoMCL	1	0.900	-	-		OOG6_102288
Panther	1	1.100	-	-	LDO	PTHR44006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R273
SonicParanoid	1	1.000	-	-		X3449
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790