DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3436 and snrnp40

DIOPT Version :9

Sequence 1:	NP_001285543.1	Gene:	CG3436 / 33180	FlyBaseID:	FBgn0031229	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001025544.1	Gene:	snrnp40 / 594941	XenbaseID:	XB-GENE-957415	Length:	337	Species:	Xenopus tropicalis

Alignment Length:	342	Identity:	197/342 - (57%)
Similarity:	257/342 - (75%)	Gaps:	11/342 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KRPNNSVILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAPIMQLEGHEGEIFTAEFHPEGE 68
            ||....::..| ||:.:|:|:.          ||..|:|:||||||.|.|||||::..:|||.|.
Frog     6 KRKGMELVPVQ-AKKPRNELVV----------SGPPRSSSLQAPIMLLSGHEGEVYCCKFHPNGV 59

  Fly    69 LLLSSGFDRQIYIWQVYEDCENVMAMSGHSGAVMEAHFTPDGSHIFTCSTDKTLAFWDIATGQRQ 133
            .|.|:||||.|.:|.||.||:|...:.||||||||.|:..|||.:|:.|||||:|.||..||:|.
Frog    60 TLSSAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSLLFSASTDKTVAIWDCETGERV 124

  Fly   134 RRFKGHGNFVNSVQGSRRGQQLLCSGSDDRTIKIWDARKKHAAHTLESPFQVTAVCFGDTGEQVI 198
            :|.|||.:||||...:|||.||:|:||||.|:|:||.|||.|..|.::.:||.:|.|.||.:|:|
Frog   125 KRLKGHTSFVNSCYPARRGPQLICTGSDDGTVKLWDFRKKAAVQTFQNTYQVLSVTFNDTSDQII 189

  Fly   199 SGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDVRPYAPGERCV 263
            ||||||::|:||:|:..:::.:|||.|::||:|||.||.::|:||||||:|||||||:||.||||
Frog   190 SGGIDNDIKVWDLRQNKLMYTMRGHGDSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV 254

  Fly   264 KVFQGHQHNFEKNLLRCAWSPGSDKITSGSADRHVYIWDVNTRRILYKLPGHNGSVNAVDFSPKE 328
            |:|||:.||||||||||:||....||.:|||||.||:||..:||||||||||.||||.|.|.|:|
Frog   255 KIFQGNVHNFEKNLLRCSWSADGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSVNEVAFHPEE 319

  Fly   329 PLILSGSSDKTLYLGEI 345
            |:|||.:|||.||:|||
Frog   320 PIILSAASDKRLYMGEI 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3436	NP_001285543.1	WD40	<19..346	CDD:225201	192/327 (59%)
		WD40	50..342	CDD:238121	176/291 (60%)
		WD40 repeat	58..96	CDD:293791	17/37 (46%)
		WD40 repeat	102..138	CDD:293791	19/35 (54%)
		WD40 repeat	143..180	CDD:293791	22/36 (61%)
		WD40 repeat	186..221	CDD:293791	16/34 (47%)
		WD40 repeat	227..267	CDD:293791	28/39 (72%)
		WD40 repeat	277..313	CDD:293791	23/35 (66%)
		WD40 repeat	319..342	CDD:293791	14/22 (64%)
snrnp40	NP_001025544.1	WD40	42..331	CDD:238121	175/288 (61%)
		WD40 repeat	50..87	CDD:293791	17/36 (47%)
		WD40 repeat	92..128	CDD:293791	20/35 (57%)
		WD40 repeat	135..170	CDD:293791	20/34 (59%)
		WD40 repeat	176..212	CDD:293791	17/35 (49%)
		WD40 repeat	218..258	CDD:293791	28/39 (72%)
		WD40 repeat	268..292	CDD:293791	15/23 (65%)
		WD40 repeat	310..332	CDD:293791	13/21 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3538
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1702
OMA	1	1.010	-	-		QHG54559
OrthoDB	1	1.010	-	-		D1133270at2759
OrthoFinder	1	1.000	-	-		FOG0004893
OrthoInspector	1	1.000	-	-		oto105355
Panther	1	1.100	-	-	LDO	PTHR44006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3449
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080