DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3436 and snrp-40.1

DIOPT Version :9

Sequence 1:	NP_001285543.1	Gene:	CG3436 / 33180	FlyBaseID:	FBgn0031229	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_509886.1	Gene:	snrp-40.1 / 181319	WormBaseID:	WBGene00008586	Length:	331	Species:	Caenorhabditis elegans

Alignment Length:	325	Identity:	172/325 - (52%)
Similarity:	230/325 - (70%)	Gaps:	5/325 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TNRDKALLESG-----VRRTSNLQAPIMQLEGHEGEIFTAEFHPEGELLLSSGFDRQIYIWQVYE 86
            |:..:.|:.||     .:|.|||.||.|.|.||||||:|..|.|:|..|.:||:|::|:.|.||.
Worm     5 TSSGQQLVSSGFPQQTAQRFSNLMAPTMVLLGHEGEIYTGAFSPDGTCLATSGYDQKIFFWNVYG 69

  Fly    87 DCENVMAMSGHSGAVMEAHFTPDGSHIFTCSTDKTLAFWDIATGQRQRRFKGHGNFVNSVQGSRR 151
            :|||...:.|||||||:..||.|.|.:.:|.|||::..||:.||...|||:.|.:|||:|..|||
Worm    70 ECENFSTIKGHSGAVMDLKFTTDSSSLVSCGTDKSVRVWDMETGTCARRFRTHTDFVNAVHPSRR 134

  Fly   152 GQQLLCSGSDDRTIKIWDARKKHAAHTLESPFQVTAVCFGDTGEQVISGGIDNEVKIWDIRKQAV 216
            |..|:.|.|||.|.::.|.|.|....|..:.:|.|||.|.|:.:|||||||||.:|:||:|:..:
Worm   135 GVTLVASASDDGTCRVHDMRTKEPVKTYTNRYQQTAVTFNDSSDQVISGGIDNVLKVWDMRRDEI 199

  Fly   217 LHHLRGHSDTITGMSLSPEGDFILTNAMDNTLRVWDVRPYAPGERCVKVFQGHQHNFEKNLLRCA 281
            .:.|.||.|||||:||||.|.||::|:||.|:|.||:||:.||:|.|.||.||.||||||||:|:
Worm   200 TYTLTGHRDTITGISLSPSGKFIISNSMDCTVRQWDIRPFVPGQRSVGVFAGHNHNFEKNLLKCS 264

  Fly   282 WSPGSDKITSGSADRHVYIWDVNTRRILYKLPGHNGSVNAVDFSPKEPLILSGSSDKTLYLGEID 346
            |||....||:||:||.:|:|:..:::|:||||||.||||..||.||||::||..|||.::|||||
Worm   265 WSPCERFITAGSSDRFLYVWETLSKKIVYKLPGHMGSVNCTDFHPKEPIMLSCGSDKRVFLGEID 329

Fly 347 346
Worm 330 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3436	NP_001285543.1	WD40	<19..346	CDD:225201	170/323 (53%)
		WD40	50..342	CDD:238121	156/291 (54%)
		WD40 repeat	58..96	CDD:293791	16/37 (43%)
		WD40 repeat	102..138	CDD:293791	16/35 (46%)
		WD40 repeat	143..180	CDD:293791	17/36 (47%)
		WD40 repeat	186..221	CDD:293791	18/34 (53%)
		WD40 repeat	227..267	CDD:293791	24/39 (62%)
		WD40 repeat	277..313	CDD:293791	17/35 (49%)
		WD40 repeat	319..342	CDD:293791	13/22 (59%)
snrp-40.1	NP_509886.1	WD40	33..323	CDD:238121	156/289 (54%)
		WD40 repeat	42..79	CDD:293791	15/36 (42%)
		WD40 repeat	84..120	CDD:293791	16/35 (46%)
		WD40 repeat	127..161	CDD:293791	15/33 (45%)
		WD40 repeat	168..204	CDD:293791	18/35 (51%)
		WD40 repeat	210..250	CDD:293791	24/39 (62%)
		WD40 repeat	260..284	CDD:293791	13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0265
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3538
Inparanoid	1	1.050	368	1.000	Inparanoid score	I1242
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54559
OrthoDB	1	1.010	-	-		D1133270at2759
OrthoFinder	1	1.000	-	-		FOG0004893
OrthoInspector	1	1.000	-	-		otm14262
orthoMCL	1	0.900	-	-		OOG6_102288
Panther	1	1.100	-	-	O	PTHR44006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R273
SonicParanoid	1	1.000	-	-		X3449
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800