DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3709 and Pus10

DIOPT Version :9

Sequence 1:	NP_608500.1	Gene:	CG3709 / 33178	FlyBaseID:	FBgn0031227	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_006514928.2	Gene:	Pus10 / 74467	MGIID:	1921717	Length:	691	Species:	Mus musculus

Alignment Length:	551	Identity:	181/551 - (32%)
Similarity:	276/551 - (50%)	Gaps:	74/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KNQDLVEYLRSCGVCEICQLRYLKA-RGAEYRN-----INETLQKL------------------D 42
            :|:.:.:.|.|.|.|..|.||:... ..|.|::     :|| |||.                  .
Mouse   158 ENKHVAQLLFSSGTCPRCILRFCGVDLPAPYKHPSKELLNE-LQKFLEPEKPELILEAPNPPLKK 221

  Fly    43 VKLNEN-VEN------EELVISEG-SQPSKRARLGVCSTCLGLF----SKDFQNELLSSILASDF 95
            ::|:|: ::|      |.:.::|. |...|.::|.||:.|||:.    .|.|..::...:.||.|
Mouse   222 IRLHEDGIDNLSEDGKEGVSVTEDESMAEKPSKLRVCNVCLGILQEFCEKGFITKVCQKVEASGF 286

  Fly    96 AKYDCQKIVLAICLPMSLQLRQLAMWFALRRRFGP---SIDENNPPDVPIKEAVKLILHPIICEK 157
               :...:||::..|..|.:|:.|.|..:::..|.   |:..|:.  |.:|||.|.|.||:..|:
Mouse   287 ---EFTSVVLSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRNDV--VQLKEAYKWITHPLFSEE 346

  Fly   158 LAKVYDANGLM-INIDLTHSLEGEEVEKLVKLNKEAF-PAKASHQ--KRIEISRGLLEKQYQPSK 218
            |....|...|. :::...|....|:...|.::.::.| |||....  .|:.:.:.|       ||
Mouse   347 LGVPTDGKSLFEVSVVFAHPETAEDCHFLGEVCRDCFKPAKNKQSVFTRMAVLKAL-------SK 404

  Fly   219 VKAETYEKYFQIPCSNVEESIKLTSIDLQGPLICVAGRYRKLSRELSHTPWILNGQRLMEDSIEE 283
            :|.|.:...|..|.::.:....:..::.....:.|||||.|.||.|..||||::|:|.||.|:||
Mouse   405 IKEEDFLGQFPCPPNSPKTVCTVLEVECTHGAVFVAGRYNKYSRNLPQTPWIIDGERKMESSVEE 469

  Fly   284 IIIRHVGPHFTEKLGKITFMSSGREDVDVRCLGKGRPFVLEIPNAKRSCLTKDEAFAMERAVD-A 347
            :|..|:...|  :.....|.||||||||||.||.||||.:|:.|..|...|..|...:::.:: :
Mouse   470 LISDHLLAVF--RAESFNFSSSGREDVDVRTLGNGRPFAVELLNPHRVHFTSQEMKELQQTINKS 532

  Fly   348 SGMVSIHHLQVVPREELTHIKTGEEQKKKFYRALCALQEPVSVKILEQLQISASFNIQQKTPIRV 412
            |..:.:..||:|.||.:.|:|.|||:|.|.|.||......:..|.:..|.......|.||||:||
Mouse   533 SDKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNRAIQKKDIGFLDDLKDLKIDQKTPLRV 597

  Fly   413 LHRRPLHTRPRTIYSVTAKVHRGNPKALIIDIVTQAGT-------------YIKELVHGEFGRTT 464
            ||||||..|.|.|:|:  |.|..:.....:.:.|||||             ||||.|||:||||.
Mouse   598 LHRRPLAVRTRAIHSM--KTHYLDEHHFRLHLKTQAGTSWYCIIFSLKRPSYIKEFVHGDFGRTK 660

  Fly   465 PSLSSIIGKPMDIQALDVVGIDLDWPHEVDN 495
            |:|.|::....||..|||..:|:|||..:|:
Mouse   661 PNLGSLMNVTADILELDVESVDVDWPPALDD 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3709	NP_608500.1	PRK14554	<253..489	CDD:237754	107/249 (43%)
CG3709	NP_608500.1	PseudoU_synth	<376..>457	CDD:294089	34/93 (37%)
Pus10	XP_006514928.2	Pus10	<437..685	CDD:333203	107/251 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836986
Domainoid	1	1.000	257	1.000	Domainoid score	I2000
eggNOG	1	0.900	-	-		E1_COG1258
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12566
Inparanoid	1	1.050	258	1.000	Inparanoid score	I3127
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54282
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006040
OrthoInspector	1	1.000	-	-		oto92154
orthoMCL	1	0.900	-	-		OOG6_101927
Panther	1	1.100	-	-	LDO	PTHR21568
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4371
SonicParanoid	1	1.000	-	-		X4334
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790