DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3709 and Pus10

DIOPT Version :9

Sequence 1:	NP_608500.1	Gene:	CG3709 / 33178	FlyBaseID:	FBgn0031227	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	XP_008768650.1	Gene:	Pus10 / 305583	RGDID:	1306402	Length:	532	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	174/527 - (33%)
Similarity:	253/527 - (48%)	Gaps:	64/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KNQDLVEYLRSCGVCEICQLRYLKA-RGAEY-RNINETLQKLDVKLNENVENEELVISEGSQPSK 64
            :|:.:.:.|...|.|..|..|:... ..|.| |...|.|..|...|..  ||.||::.....|.|
  Rat     7 ENRRVAQLLLRSGTCPRCIFRFCGVDLPAPYKRPYKELLDDLQTFLES--ENRELILEGPDPPLK 69

  Fly    65 RARL--------------------------------GVCSTCLGLF----SKDFQNELLSSILAS 93
            :.||                                .||:.|||:.    .|||..|:...:.||
  Rat    70 KIRLHEDGVDTLSANGEEGVSVTEDENMAATKPSNWRVCNVCLGILQGFCEKDFITEVCQKVEAS 134

  Fly    94 DFAKYDCQKIVLAICLPMSLQLRQLAMWFALRRRFGP---SIDENNPPDVPIKEAVKLILHPIIC 155
            .|   :...:||::..|..|.:|:.|.|..:::..|.   |:..|:.  |.:|||.|.|.||:..
  Rat   135 GF---EFTSVVLSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRNDV--VQLKEAYKWITHPLFS 194

  Fly   156 EKLAKVYDANGLM-INIDLTHSLEGEEVEKLVKLNKEAF-PAKASHQ--KRIEISRGLLEKQYQP 216
            |:|....|...|. :::...|....::...|.::..:.| |||....  .|:.:.:.|
  Rat   195 EELGVPTDGKSLFEVSVVFAHPETLQDCHFLGEVCPDCFKPAKNKQSVFTRMAVLKAL------- 252

  Fly   217 SKVKAETYEKYFQIPCSNVEESIKLTSIDLQGPLICVAGRYRKLSRELSHTPWILNGQRLMEDSI 281
            |::|.|.:...|..|..:.:....:..::.....:.|||||.|.||.|..||||::|:|.||.|:
  Rat   253 SRIKEEDFLTQFPCPPDSPKTICTVLEVECTHGAVFVAGRYNKYSRNLPQTPWIIDGERKMESSV 317

  Fly   282 EEIIIRHVGPHFTEKLGKITFMSSGREDVDVRCLGKGRPFVLEIPNAKRSCLTKDEAFAMERAVD 346
            ||:|..|:...|  |.....|.||||||||||.||.||||.:|:.|..|...|..|...:::.::
  Rat   318 EELISDHLLAVF--KAESFNFSSSGREDVDVRTLGNGRPFAVELLNPHRVHFTSQEIKELQQKIN 380

  Fly   347 -ASGMVSIHHLQVVPREELTHIKTGEEQKKKFYRALCALQEPVSVKILEQLQISASFNIQQKTPI 410
             :|..:.:..||:|.||.:.|:|.|||:|.|.|.||......:..|.:..|.......|.||||:
  Rat   381 KSSDKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNRAIQKKDIGFLDDLKDLKIDQKTPL 445

  Fly   411 RVLHRRPLHTRPRTIYSVTAKVHRGNPKALIIDIVTQAGTYIKELVHGEFGRTTPSLSSIIGKPM 475
            ||||||||..|.|.|:|:  |.|..:.....:.:.|||||||||.|||:||||.|::.|::....
  Rat   446 RVLHRRPLAVRTRAIHSM--KTHYLDEHHFRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMNVTA 508

  Fly   476 DIQALDV 482
            ||..|||
  Rat   509 DIVELDV 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3709	NP_608500.1	PRK14554	<253..489	CDD:237754	106/231 (46%)
CG3709	NP_608500.1	PseudoU_synth	<376..>457	CDD:294089	34/80 (43%)
Pus10	XP_008768650.1	PRK14554	<287..515	CDD:237754	104/231 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340712
Domainoid	1	1.000	252	1.000	Domainoid score	I2018
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12566
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3127
OMA	1	1.010	-	-		QHG54282
OrthoDB	1	1.010	-	-		D1067006at2759
OrthoFinder	1	1.000	-	-		FOG0006040
OrthoInspector	1	1.000	-	-		oto95722
orthoMCL	1	0.900	-	-		OOG6_101927
Panther	1	1.100	-	-	LDO	PTHR21568
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4334
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910