DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3709 and PUS10

DIOPT Version :9

Sequence 1:	NP_608500.1	Gene:	CG3709 / 33178	FlyBaseID:	FBgn0031227	Length:	500	Species:	Drosophila melanogaster
Sequence 2:	NP_001309052.1	Gene:	PUS10 / 150962	HGNCID:	26505	Length:	529	Species:	Homo sapiens

Alignment Length:	543	Identity:	178/543 - (32%)
Similarity:	266/543 - (48%)	Gaps:	69/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KNQDLVEYLRSCGVCEICQLRYLKARGAE--------YRNINETLQK----------LDV----- 43
            :|:.:.:.|.:.|.|..|..|:.   |.:        |:.:...|||          |:|
Human     7 ENKHVAQLLLNTGTCPRCIFRFC---GVDFHAPYKLPYKELLNELQKFLETEKDELILEVMNPPP 68

  Fly    44 -------------KLNENVENEELVISEGSQPSKRARLGVCSTCLGLF----SKDFQNELLSSIL 91
                         .|::|.|....|...||..||.:.|.||:.|||:.    .|||..::...:.
Human    69 KKIRLQELEDSIDNLSQNGEGRISVSHVGSTASKNSNLNVCNVCLGILQEFCEKDFIKKVCQKVE 133

  Fly    92 ASDFAKYDCQKIVLAICLPMSLQLRQLAMWFALRRRFG-PSIDENNPPDVPIKEAVKLILHPIIC 155
            ||.|   :...:|.::..|..|.:|:.|.|..:::..| .|:.......|.:|||.|.|.||:..
Human   134 ASGF---EFTSLVFSVSFPPQLSVREHAAWLLVKQEMGKQSLSLGRDDIVQLKEAYKWITHPLFS 195

  Fly   156 EKLAKVYDANGLM-INIDLTHSLEGEEVEKLVKLNKEAF-PAKASHQ--KRIEISRGLLEKQYQP 216
            |:|....|...|. :::...|....|:...|..:..:.| |||....  .|:.:.:.|
Human   196 EELGVPIDGKSLFEVSVVFAHPETVEDCHFLAAICPDCFKPAKNKQSVFTRMAVMKAL------- 253

  Fly   217 SKVKAETYEKYFQIPCSNVEESIKLTSIDLQGPLICVAGRYRKLSRELSHTPWILNGQRLMEDSI 281
            :|:|.|.:.|.|..|.::.:....:..|:.....:.|||||.|.||.|..||||::|:|.:|.|:
Human   254 NKIKEEDFLKQFPCPPNSPKAVCAVLEIECAHGAVFVAGRYNKYSRNLPQTPWIIDGERKLESSV 318

  Fly   282 EEIIIRHVGPHFTEKLGKITFMSSGREDVDVRCLGKGRPFVLEIPNAKRSCLTKDEAFAMERAV- 345
            ||:|..|:...|  |.....|.||||||||||.||.||||.:|:.|..|...|..|...:::.:
Human   319 EELISDHLLAVF--KAESFNFSSSGREDVDVRTLGNGRPFAIELVNPHRVHFTSQEIKELQQKIN 381

  Fly   346 DASGMVSIHHLQVVPREELTHIKTGEEQKKKFYRALCALQEPVSVKILEQLQISASFNIQQKTPI 410
            ::|..:.:..||:|.||.:.|:|.|||:|.|.|.||....:.:..|.:|.|.......|.||||:
Human   382 NSSNKIQVRDLQLVTREAIGHMKEGEEEKTKTYSALIWTNKAIQKKDIEFLNDIKDLKIDQKTPL 446

  Fly   411 RVLHRRPLHTRPRTIYSVTAKV---HRGNPKALIIDIVTQAGTYIKELVHGEFGRTTPSLSSIIG 472
            ||||||||..|.|.|:.:..:.   |.     ..:.:.|||||||||.|||:||||.|::.|::.
Human   447 RVLHRRPLAVRARVIHFMETQYVDEHH-----FRLHLKTQAGTYIKEFVHGDFGRTKPNIGSLMN 506

  Fly   473 KPMDIQALDVVGIDLDWPHEVDN 495
            ...||..|||..:|:|||..:|:
Human   507 VTADILELDVESVDVDWPPALDD 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3709	NP_608500.1	PRK14554	<253..489	CDD:237754	105/239 (44%)
CG3709	NP_608500.1	PseudoU_synth	<376..>457	CDD:294089	33/83 (40%)
PUS10	NP_001309052.1	Pus10	<288..523	CDD:333203	105/241 (44%)
		RNA binding forefinger loop. /evidence=ECO:0000255	304..317		7/12 (58%)
		RNA binding thumb loop. /evidence=ECO:0000255	442..457		12/14 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147046
Domainoid	1	1.000	261	1.000	Domainoid score	I1970
eggNOG	1	0.900	-	-		E1_COG1258
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12566
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3102
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54282
OrthoDB	1	1.010	-	-		D1067006at2759
OrthoFinder	1	1.000	-	-		FOG0006040
OrthoInspector	1	1.000	-	-		oto88589
orthoMCL	1	0.900	-	-		OOG6_101927
Panther	1	1.100	-	-	LDO	PTHR21568
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4371
SonicParanoid	1	1.000	-	-		X4334
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800