Protein Alignment CG42399 and TOGARAM1

DIOPT Version :10

• Sequence 1: NP_608498.3
• Gene: CG42399 / 33176
• FlyBaseID: FBgn0259818
• Length: 1655
• Species: Drosophila melanogaster
• Sequence 2: NP_001295049.1
• Gene: TOGARAM1 / 23116
• HGNCID: 19959
• Length: 1773
• Species: Homo sapiens
• Alignment Length: 1177
• Identity: 269/1177 - (22%)
• Similarity: 452/1177 - (38%)
• Gaps: 251/1177 - (21%)

  Fly   665 DWRNRLMGIGQLELAL-----SSSSNLALVQPYLDSLLRTLLSSERHFEVSDLKRELLVNLISRL 724
            |::||...:.:|:..|     ||:.:.:||.  ..|||..|| .:.:|:|.....|:|..|:.|
Human   364 DYKNRTQAVEELKQVLGKFNPSSTPHSSLVG--FISLLYNLL-DDSNFKVVHGTLEVLHLLVIR- 424

  Fly   725 PLDNLEERTPQILSGLCRQG---NAGANRVCK--------ALMQRLPAGTIVAKLTSPEFLHAKS 778
                |.|:..|.|..:....   .|....|.|        .||:.:....::..|.  |.|..|.
Human   425 ----LGEQVQQFLGPVIAASVKVLADNKLVIKQEYMKIFLKLMKEVGPQQVLCLLL--EHLKHKH 483

  Fly   779 SKFRDHALQMSIFALMTFPGTCFDISLLTTQAVYSLLNRKRRVRQAALEVLAVLADISSIKEVLT 843
            |:.|:..:.:.|.:|:|:|...||:..|:.....:|::.||||||||||..||||  ||:....|
Human   484 SRVREEVVNICICSLLTYPSEDFDLPKLSFDLAPALVDSKRRVRQAALEAFAVLA--SSMGSGKT 546

  Fly   844 -IVSETTDGVEL---GPMVLEATSVRLSRLQLPIVTPDSGVLFVFNQTDPPGAR----RFGADVD 900
             |:.:..|.|||   |..|:.|...||:|..||.:|....|.:........|.|    ..|||.|
Human   547 SILFKAVDTVELQDNGDGVMNAVQARLARKTLPRLTEQGFVEYAVLMPSSAGGRSNHLAHGADTD 611

  Fly   901 WI-----------HQGE---------GSASPNTIKRRRMRAASSQRNVL------GGAEAKNKND 939
            |:           |.|:         ||.|| ||..||:.:|...:|.|      .|...:|:..
Human   612 WLLAGNRTQSAHCHCGDHVRDSMHIYGSYSP-TICTRRVLSAGKGKNKLPWENEQPGIMGENQTS 675

  Fly   940 PFPSFRQVNESVHRHSF-HSPPETLDMASPINDFSQRLSFGAKTNGGSQSFIERRFLAKACSDTS 1003
            ......|.:    .:.| .|....|....|:||   .|.|..| ......|...|.....|....
Human   676 TSKDIEQFS----TYDFIPSAKLKLSQGMPVND---DLCFSRK-RVSRNLFQNSRDFNPDCLPLC 732

  Fly  1004 MDGRSTDSTTTTCSSGSATDSFIQLTSRTGGRLAGPNSRF-PTMNQHADFVN---NFMRSMQR-- 1062
            ..| :|.:..|..|...|...|.|:..:||.  .|.:.:| .|.:.|.:.|.   ||....|:
Human   733 AAG-TTGTHQTNLSGKCAQLGFSQICGKTGS--VGSDLQFLGTTSSHQEKVYASLNFGSKTQQTF 794

  Fly  1063 GSKSHSVER------------PNYPKVS-----------YSIPKSQQMIRKKFQHK---DSFTKL 1101
            ||::.....            |:||..|           ...||..|.....|.:.   .||..|
Human   795 GSQTECTSSNGQNPSPGAYILPSYPVSSPRTSPKHTSPLIISPKKSQDNSVNFSNSWPLKSFEGL 859

  Fly  1102 GDEPPGQSIENNKFNESQRRKSGISTDHMESLDSKCADVIKSVDTETEVNGMTNGSPISASSTSY 1166
            ....|.:.:.:.|.::...|..|.::.....:....| :::|..:...:||.....||....:..
Human   860 SKPSPQKKLVSQKSSDPTGRNHGENSQEKPPVQLTPA-LVRSPSSRRGLNGTKPVPPIPRGISLL 923

  Fly  1167 SQKSTASAKSSISQNEMGKRPFSSTGLWNDCKVEVLNREHNPNEAFGELVVDAIKVQTESEPTAH 1231
            ..|:..|.        :|.:......:|. |:.:             .|.:|..::..:.:....
Human   924 PDKADLST--------VGHKKKEPDDIWK-CEKD-------------SLPIDLSELNFKDKDLDQ 966

  Fly  1232 EEL---------------LKLNGSLNSLHSKTESIKTQLEETTPQLSRAQSVKS-----LLIEED 1276
            ||:               .||:||.:.|.|...::|..|...:|.||.:.::.|     :..:|.
Human   967 EEMHSSLRSLRNSAAKKRAKLSGSTSDLESPDSAMKLDLTMDSPSLSSSPNINSYSESGVYSQES 1031

  Fly  1277 IESSNSFV-------------------------VVEEVENELESSPAKGEEEVPLQEELATPVKA 1316
            :.||.|..                         ..:::.:..|.||:.|....|.|
Human  1032 LTSSLSTTPQGKRIMSDIFPTFGSKPCPTRLSSAKKKISHIAEQSPSAGSSSNPQQ--------- 1087

  Fly  1317 TKLENHTFGPKLVPTHDEIVIHSRSV--SLDSLYGTRPASKQGSMDT-STSTAENTSQTGSQIGN 1378
              :.:..|......:.|.:|:..:.|  ||.|...|...|...|::. .|.:.:.:.:..|.|..
Human  1088 --ISSFDFTTTKALSEDSVVVVGKGVFGSLSSAPATCSQSVISSVENGDTFSIKQSIEPPSGIYG 1150

  Fly  1379 TSVP-------------------AKAQHTPLKHKSKTSYFL------------------------ 1400
            .||.                   :|:.:..::.|.|....|
Human  1151 RSVQQNISSYLDVENEKDAKVSISKSTYNKMRQKRKEEKELFHNKDCEKKEKNSWERMRHTGTEK 1215

  Fly  1401 --------------RAQRRISPSKQPIKMSQAELFPQNMVRFDRPREALLKTFDQLDSSNWEVNV 1451
                          ..:|..|.:..|..|..:||.|     |.:|..||.:....|...:||..:
Human  1216 MASESETPTGAISQYKERMPSVTHSPEIMDLSELRP-----FSKPEIALTEALRLLADEDWEKKI 1275

  Fly  1452 SGLKSMVRLIRYHAETLDNQMHMTCIQLTRSVRNLRSQVARASCQAAAELFSLKSTSLQQECDDL 1516
            .||..:..|..:|:|.|:.::|.|...:.:.|:||||.|:||:....::||:....|:.||.|..
Human  1276 EGLNFIRCLAAFHSEILNTKLHETNFAVVQEVKNLRSGVSRAAVVCLSDLFTYLKKSMDQELDTT 1340

  Fly  1517 VCALLHRTADTNRFLRADANRALESMVDHAQPQKILNILATKGAQHQNALVRTTSAKLLFRLVER 1581
            |..|||:..::|.|:|.|.::||.:||::..|.:.:..|...|..|.:..||..:|:.|..::|.
Human  1341 VKVLLHKAGESNTFIREDVDKALRAMVNNVTPARAVVSLINGGQSHLHIAVRRCTAQHLSDVLEF 1405

  Fly  1582 LGSDRIYAMGRESRDKFFVVGANLLLEGSLETRSYAKSLFRALSENHNYQRLLLEVIPPRTYRNV 1646
            :..:||.:..::..::.....|....:.|.|||.|.:.:...:..:.|::::|.:.:|.:....:
Human  1406 MEPERILSAAKDMAERILPAAAKFAQDSSQETRYYGRKMLFFMMCHPNFEKMLEKYVPSKDLPYI 1470

  Fly  1647 EKTLRSI 1653
            :.::|::
Human  1471 KDSVRNL 1477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42399	NP_608498.3	PHA03307	387..>646	CDD:223039
TOGARAM1	NP_001295049.1	HEAT repeat	395..423	CDD:293787	10/28 (36%)
		HEAT repeat	435..465	CDD:293787	5/29 (17%)
		HEAT repeat	470..501	CDD:293787	8/32 (25%)
		HEAT repeat	512..537	CDD:293787	12/24 (50%)