DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42399 and TOGARAM2

DIOPT Version :9

Sequence 1:	NP_608498.3	Gene:	CG42399 / 33176	FlyBaseID:	FBgn0259818	Length:	1655	Species:	Drosophila melanogaster
Sequence 2:	NP_954974.2	Gene:	TOGARAM2 / 165186	HGNCID:	33715	Length:	1019	Species:	Homo sapiens

Alignment Length:	732	Identity:	147/732 - (20%)
Similarity:	269/732 - (36%)	Gaps:	206/732 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1034 GRLAG-----PNSRFPTMNQHADFVNNFMRSMQRGSKSHSVERPNYPKVSYSIPKSQ--QMIRKK 1091
            |:|.|     |:..:...|.|.    ..:|::..|.:         |.|....|:|:  .:.|..
Human    70 GQLGGLKLDTPSKGWQARNGHP----RNLRALSLGDQ---------PLVLLPSPESEANSVARDT 121

  Fly  1092 FQHKDSFTKLGDEPPGQSIENNKFNESQRRKSGISTDHMESLD---------------------- 1134
            .|.||...|                  :|...|::.....|||
Human   122 IQIKDKLKK------------------RRLSEGLAASSRASLDPGGGPQGVPLHSTIPRATSQRL 168

  Fly  1135 ---SKCADVIKSVDTETEVNGM-TNGSPISASSTSYSQKSTASAKSSISQNEMGKRPFSSTGLW- 1194
               .:...:|:|:.|..|.:|: ..|..:..|.....:....:.::.||              |
Human   169 LRVPRPMPLIQSIPTTPEASGVKEKGLDLPGSIPGPHELRPGAQEAQIS--------------WQ 219

  Fly  1195 ----NDCKVEVLNREHNPNEAFGELVVDAI-KVQTESEPTAHEELLKLNGSLNSLHSKTESIKTQ 1254
                ||.|::         ::.|.:|:..| |.:|.:...:     ::.|||.|.....:.:.|.
Human   220 YLHCNDEKMQ---------KSLGAIVIPPIPKARTVAATPS-----RVPGSLPSPLPPGQGVLTG 270

  Fly  1255 LEETTPQLSR-----------------------------------AQSVKSL------------- 1271
            |.....:|:|                                   :||..:|
Human   271 LRAPRTRLARGSGPREKTPASLEPKPLASPIRDRPAAAKKPALPFSQSAPTLTAFSFDCAREACP 335

  Fly  1272 -LIEEDIESSNSFVVVEEVENELESSPAKGEEEVPLQEELATPVKATKLENHTFGPK-------- 1327
             |.|||.:...:.:.|...::..|....|..:|:.|...|..|....:|.:...|.:
Human   336 PLKEEDQKEIGTKIQVTISKSAREKMQLKQMKEMELLRRLEEPRTGQELTSQCLGSQRAFMKEGL 400

  Fly  1328 ---------LVPT-------HDEIVIHSRSVSLDSLYGTRPASKQGSMDTSTSTAENTSQTGSQI 1376
                     .|||       :|..:|..:..|..|| .:.|.|:|.......::|
Human   401 LPLRGSGTLSVPTRLSGPCRNDVSIILRKWASRASL-PSIPISRQEPRFARHASA---------- 454

  Fly  1377 GNTSVPAKAQHTPLKHKSKTSYFLRAQRRISPSKQPIKMSQAELFPQNMVRFDRPREALLKTFDQ 1441
              .|:||.......:.:.:....|||.:.:.|                   |..|...|......
Human   455 --NSLPAVLTLGSPEWEEEEEMDLRACKELRP-------------------FSNPELGLRDALQC 498

  Fly  1442 LDSSNWEVNVSGLKSMVRLIRYHAETLDNQMHMTCIQLTRSVRNLRSQVARASCQAAAELFSLKS 1506
            |:||:|::...||.|:.||...|:|.|..::|..|:.:|..|.||||:|:..:.....:||....
Human   499 LNSSDWQMKEKGLVSIQRLAACHSEVLTGKLHDVCLVVTGEVTNLRSKVSHLAISTLGDLFQALK 563

  Fly  1507 TSLQQECDDLVCALLHRTADTNRFLRADANRALESMVDHAQPQKILNILATKGAQHQNALVRTTS 1571
            .::.||.:::...||.:.||||.|::..|.::|.:||::....:.|.:|.:.|..|:|.|:|..:
Human   564 KNMDQEAEEIARCLLQKMADTNEFIQRAAGQSLRAMVENVTLARSLVVLTSAGVYHRNPLIRKYA 628

  Fly  1572 AKLLFRLVERLGSDRIYAMGRESRDKFFVVGANLLLEGSLETRSYAKSLFRALSENHNYQRLLLE 1636
            |:.|..::|::|::::.:..|:|.|........|..:.:.:||.|.:.:...|..|..:...|.:
Human   629 AEHLSAVLEQIGAEKLLSGTRDSTDMLVHNLVRLAQDSNQDTRFYGRKMVNILMANTKFDAFLKQ 693

  Fly  1637 VIPPRTYRNVEKTLRSI 1653
            .:|  :| :::|.:.:|
Human   694 SLP--SY-DLQKVMAAI 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42399	NP_608498.3	CLASP_N	1433..1627	CDD:289144	56/193 (29%)
TOGARAM2	NP_954974.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..158		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..311		8/66 (12%)
		CLASP_N	503..678	CDD:289144	51/174 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	991..1019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7383
eggNOG	1	0.900	-	-		E1_KOG2933
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004509
OrthoInspector	1	1.000	-	-		otm41815
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3085
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.930