Protein Alignment CG3164 and ABCG2

DIOPT Version :10

• Sequence 1: NP_722605.1
• Gene: CG3164 / 33171
• FlyBaseID: FBgn0288229
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_004818.2
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 190/687 - (27%)
• Similarity: 325/687 - (47%)
• Gaps: 112/687 - (16%)

  Fly    47 LAFHNLTYRV--KEG----NRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSGYK-TS 104
            |:|||:.|||  |.|    .:...|.||..::|.::.| |.||:||:|.|||:||::|:..| .|
Human    37 LSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPS 100

  Fly   105 SIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHSMIDDI 169
            .:.|.|.:|||.|..: |:..|.|::||:.:.|.|||:|.:..:..|:|:...:..||:..|:.:
Human   101 GLSGDVLINGAPRPAN-FKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRV 164

  Fly   170 LLTLSL-----SEHRYTMTRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCIHLLK 229
            :..|.|     |:......|.:|||::||.||.:||:::|.|:|.||||:||||||....:.|||
Human   165 IQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLK 229

  Fly   230 MLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYHNPASYV 294
            .::..|||:|.:||||...:|::||.|..||.|:.::.|..::.:.:..:....|.:|:|||.:.
Human   230 RMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFF 294

  Fly   295 IEVSCGEHGDHTR---------KLVDAIDNGKRDVRSSADYAGLKARNDLVKVQNLKAILDKNDA 350
            :::.   :||.|.         |..:.|:..|:|                      |.:::|...
Human   295 LDII---NGDSTAVALNREEDFKATEIIEPSKQD----------------------KPLIEKLAE 334

  Fly   351 SSVSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSVNCTTALLTEEIT 415
            ..|:...|::.....:.|..|                            ||....|   :.:||:
Human   335 IYVNSSFYKETKAELHQLSGG----------------------------EKKKKIT---VFKEIS 368

  Fly   416 SPERYPTSQFHQFWVVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGALYYDIGNDGAKVLSNLGF 480
                |.||..||...|.||:......:......::...:::|.:|||:|:.:.||...:.:..|.
Human   369 ----YTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGV 429

  Fly   481 LFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVAD-LPFQAIFCVIYVSIV 544
            |||......::|::...| |.:|..:.:.|..:.:|.:.||:|...::| ||.:.:..:|:..||
Human   430 LFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIV 493

  Fly   545 YYFTSQPWELFRFSMFLSACLLISFVAQSVGLVVGAAMNVQN-GVFLAPVMSVPFLLFSGFFVSF 608
            |:......:...|.:.:...:::::.|.|:.|.:.|..:|.: ...|..:..|..::|||..|:.
Human   494 YFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNL 558

  Fly   609 DAIPVYLRWITYLSYIRYGFEGTALATYGYGREKLRCFQTYC-----HFKSP---ITTLEELDMV 665
            ..|..:|.|:.|.|..||||  |||....:      ..|.:|     ...:|   .|...|..:|
Human   559 TTIASWLSWLQYFSIPRYGF--TALQHNEF------LGQNFCPGLNATGNNPCNYATCTGEEYLV 615

  Fly   666 NANFTLD----------IVALIVIFVVLRISAYLFLR 692
            .....|.          :..:||||:.:.....|||:
Human   616 KQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLK 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	3a01204	60..699	CDD:273361	181/668 (27%)
ABCG2	NP_004818.2	3a01204	55..649	CDD:273361	178/664 (27%)