DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and PDR12

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_015267.1	Gene:	PDR12 / 856049	SGDID:	S000005979	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	778	Identity:	181/778 - (23%)
Similarity:	303/778 - (38%)	Gaps:	202/778 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LGTAGAGQLKAQIVPAQPKTLQHLPKRPAVDL----------AFHNLTYRVKEGNRSNAKTILKG 70
            |||..|....|    ::.:.::.| ..|.|||          .:::|.|.:.....:  :.:|..
Yeast   806 LGTENADARTA----SREEMMEAL-NGPNVDLEKVIAEKDVFTWNHLDYTIPYDGAT--RKLLSD 863

  Fly    71 VSGRLRSGELTAIMGPSGAGKSTLLNILS-GYKTSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQ 134
            |.|.::.|::||:||.|||||:||||:|: ......|.|.:.:| |:...::|.:...|:.|.:.
Yeast   864 VFGYVKPGKMTALMGESGAGKTTLLNVLAQRINMGVITGDMLVN-AKPLPASFNRSCGYVAQADN 927

  Fly   135 LHGNLTVQEAMTVATNLKLSKKFSKPEKHSMIDDILLTLSLSEHRYTMT----RNLSGGQKKRLS 195
            ....|:|:|::..|..|:........||:..::.|:..|.:..:...:.    |.|:..|:|:||
Yeast   928 HMAELSVRESLRFAAELRQQSSVPLEEKYEYVEKIITLLGMQNYAEALVGKTGRGLNVEQRKKLS 992

  Fly   196 IALELVSNPP-IMFFDEPTSGLDSSTCFQCIHLLKMLAAGGRTVICTIHQPSARLFEMFDQLYTL 259
            |.:|||:.|. ::|.|||||||||.:.:..:..::.||..|::::||||||||.|||.||:|..|
Yeast   993 IGVELVAKPSLLLFLDEPTSGLDSQSAWSIVQFMRALADSGQSILCTIHQPSATLFEQFDRLLLL 1057

  Fly   260 -ADGQCVYQG-----STKQLVPFLSTLNLECPSYHNPASYVIEVSCGEHGDHTRKLVDAIDNGKR 318
             ..|:.||.|     |...|..|.....::|....|||.|::  :|...|     ...::::...
Yeast  1058 KKGGKMVYFGDIGPNSETLLKYFERQSGMKCGVSENPAEYIL--NCIGAG-----ATASVNSDWH 1115

  Fly   319 DV-RSSADYAGLKARNDLVKVQNLKAILDKNDASSVSGRKYEDNLTLNNGLLNGMVNDIVKEGNV 382
            |: .:|.:.|..:|     :|:.|...|        .||               .|||
Yeast  1116 DLWLASPECAAARA-----EVEELHRTL--------PGR---------------AVND------- 1145

  Fly   383 SSALVTTNERGDAMIDVEKSVNCTTALLTEEITSPE---RYPTSQFHQFWVVLKRTLLFSYRDWT 444
                                             .||   |:..|...|...||:||.|..:|...
Yeast  1146 ---------------------------------DPELATRFAASYMTQIKCVLRRTALQFWRSPV 1177

  Fly   445 LMYLRLFAHLLVGFLIGALYYDIGNDGAKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLK 509
            .:..:.|..:.....:|..|..:.:.....:.....:|  ||.|:..:|...:..|..:...|.:
Yeast  1178 YIRAKFFECVACALFVGLSYVGVNHSVGGAIEAFSSIF--MLLLIALAMINQLHVFAYDSRELYE 1240

  Fly   510 -----ENFNRWYSLKSYYLAISVADLPFQAIFCVIYVSIVYYFTSQPWELFR--------FSMFL 561
                 .|...|..|...:.|:.    .|.:..|.....|.||:.:|    |.        |..|.
Yeast  1241 VREAASNTFHWSVLLLCHAAVE----NFWSTLCQFMCFICYYWPAQ----FSGRASHAGFFFFFY 1297

  Fly   562 SACLLISFVAQSVGLV-----VGAAMNVQNGVFLAPVMSVPFLLFSGFFVSFDAIPVYLRWITY- 620
            .....:.||...:.::     |.:|..:.:.:|.|      .|||.|.....:.:|.:.|.:.|
Yeast  1298 VLIFPLYFVTYGLWILYMSPDVPSASMINSNLFAA------MLLFCGILQPREKMPAFWRRLMYN 1356

  Fly   621 LSYIRYGFEGTALATYGYGREKLRC-------------------FQTY----------------C 650
            :|...|..:  ||.|.....:|:.|                   ..||                |
Yeast  1357 VSPFTYVVQ--ALVTPLVHNKKVVCNPHEYNIMDPPSGKTCGEFLSTYMDNNTGYLVNPTATENC 1419

  Fly   651 HFKSPITTLEEL--------DMVNANF-------TLDIVALIVIFVVLRISAYLFLRWKLKTV 698
            .: .|.|..:::        |....||       ..:|.|:::.:.|:|:..     |.||:|
Yeast  1420 QY-CPYTVQDQVVAKYNVKWDHRWRNFGFMWAYICFNIAAMLICYYVVRVKV-----WSLKSV 1476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	81/240 (34%)
		3a01204	60..699	CDD:273361	169/724 (23%)
		ABC2_membrane	431..630	CDD:279410	44/217 (20%)
PDR12	NP_015267.1	3a01205	89..1468	CDD:273362	176/763 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	2	2.000