DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and PDR5

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_014796.3	Gene:	PDR5 / 854324	SGDID:	S000005679	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	736	Identity:	177/736 - (24%)
Similarity:	303/736 - (41%)	Gaps:	181/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LPKRPAVDLAFH--NLTYRVKEGNRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSGY 101
            |.|..|:   ||  ||.|.|:  .::..:.||..|.|.::.|.|||:||.|||||:|||:.|:..
Yeast   862 LSKSEAI---FHWRNLCYEVQ--IKAETRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAER 921

  Fly   102 KTSS-IEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHSM 165
            .|.. |.|.:.:||..|:.|..|.:.....||..|. ..||:|::..:..|:...:.|..||:..
Yeast   922 VTMGVITGDILVNGIPRDKSFPRSIGYCQQQDLHLK-TATVRESLRFSAYLRQPAEVSIEEKNRY 985

  Fly   166 IDDILLTLSLSEHRYTMT----RNLSGGQKKRLSIALELVSNPPIM-FFDEPTSGLDSSTCFQCI 225
            :::::..|.:.::...:.    ..|:..|:|||:|.:||.:.|.:: |.|||||||||.|.:...
Yeast   986 VEEVIKILEMEKYADAVVGVAGEGLNVEQRKRLTIGVELTAKPKLLVFLDEPTSGLDSQTAWSIC 1050

  Fly   226 HLLKMLAAGGRTVICTIHQPSARLFEMFDQ-LYTLADGQCVYQG----STKQLVPFLSTLNL-EC 284
            .|:|.||..|:.::||||||||.|.:.||: |:....|:.||.|    ..|.::.:..:... :|
Yeast  1051 QLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKC 1115

  Fly   285 PSYHNPASYVIEVSCGEHGDHTRKLVDAIDNGKRDV----RSSADYAGLKARNDLVKVQNLKAIL 345
            |:..|||.:::||.....|.|          ..:|.    |:|.:|..:::.
Yeast  1116 PADANPAEWMLEVVGAAPGSH----------ANQDYYEVWRNSEEYRAVQSE------------- 1157

  Fly   346 DKNDASSVSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSVNCTTALL 410
                                   |:.|..::.|:|::::|        :...:..:|:...|.|:
Yeast  1158 -----------------------LDWMERELPKKGSITAA--------EDKHEFSQSIIYQTKLV 1191

  Fly   411 TEEITSPERYPTSQFHQFWVVLKRTLLFSYRD----WTLMYLRLFAHLLVGFLI---GALYYDIG 468
            :..:          |.|:|           |.    |:...|.:|..|.:||..   |.....:.
Yeast  1192 SIRL----------FQQYW-----------RSPDYLWSKFILTIFNQLFIGFTFFKAGTSLQGLQ 1235

  Fly   469 NDGAKVLSNLGFLF---FNMLFLMYTSMTITILSFPLEMPVL-LKENFNRWYSLKSYYLAISVAD 529
            |....|     |:|   ||.:...|      :.||..:..:. .:|..:|.:|..|:..|....:
Yeast  1236 NQMLAV-----FMFTVIFNPILQQY------LPSFVQQRDLYEARERPSRTFSWISFIFAQIFVE 1289

  Fly   530 LPFQAIFCVIYVSIVYY------FTSQPWELF-RFSMF-LSACLLISFVAQSVGLVVGAAMNV-Q 585
            :|:..:...|...|.||      ..|...:|. |.::| |.:|....:|. |:||:|.:...| :
Yeast  1290 VPWNILAGTIAYFIYYYPIGFYSNASAAGQLHERGALFWLFSCAFYVYVG-SMGLLVISFNQVAE 1353

  Fly   586 NGVFLAPVMSVPFLLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGYGREKLRC----- 645
            :...||.::....|.|.|...:..|:|.:..::..:|.:.|..:  ||...|.....::|
Yeast  1354 SAANLASLLFTMSLSFCGVMTTPSAMPRFWIFMYRVSPLTYFIQ--ALLAVGVANVDVKCADYEL 1416

  Fly   646 --------------FQTY-----------------CHFKSPITTLEELDMVNA-------NFTLD 672
                          .:.|                 |.|....||.:.|..||:       |:
Yeast  1417 LEFTPPSGMTCGQYMEPYLQLAKTGYLTDENATDTCSFCQISTTNDYLANVNSFYSERWRNY--- 1478

  Fly   673 IVALIVIFVVLRISAYLFLRW 693
              .:.:.::.....|.:|..|
Yeast  1479 --GIFICYIAFNYIAGVFFYW 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	85/232 (37%)
		3a01204	60..699	CDD:273361	168/713 (24%)
		ABC2_membrane	431..630	CDD:279410	48/218 (22%)
PDR5	NP_014796.3	ABC_trans_N	46..152	CDD:405234
PDR5	NP_014796.3	3a01205	100..1503	CDD:273362	177/736 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	2	2.000