DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and ADP1

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_009937.2	Gene:	ADP1 / 850369	SGDID:	S000000604	Length:	1049	Species:	Saccharomyces cerevisiae

Alignment Length:	750	Identity:	205/750 - (27%)
Similarity:	341/750 - (45%)	Gaps:	104/750 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YSWKQFLENNNLLGTAGAGQLKAQIVPAQPKTLQHLPKRPAVD------------LAFHNLTYRV 56
            :::..|..:.:.|...|.|..|:.|         .||...||:            |:|.|:||.|
Yeast   338 FTFATFYISKSPLFRNGLGSSKSPI---------RLPDEDAVNNFLQNEDDTLATLSFENITYSV 393

  Fly    57 KEGNRSNA-KTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILS-GYKTSSIEGSVTMNGAERNL 119
            ...|.... :|:|..:||.::.|::.||||.|||||:|||:||: ..||..:.||:.:||...:.
Yeast   394 PSINSDGVEETVLNEISGIVKPGQILAIMGGSGAGKTTLLDILAMKRKTGHVSGSIKVNGISMDR 458

  Fly   120 SAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHSMIDDILLTLSLSEHR----- 179
            .:|.|:..::.||:.|...|||.|.:..:..|:|.|..|...|.:.:..:|..|.:.:.:
Yeast   459 KSFSKIIGFVDQDDFLLPTLTVFETVLNSALLRLPKALSFEAKKARVYKVLEELRIIDIKDRIIG 523

  Fly   180 YTMTRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCIHLLKMLAAG-GRTVICTIH 243
            ....|.:|||:|:|:|||.|||::|.::|.||||||||:|.....|..|..|::. .||::.:||
Yeast   524 NEFDRGISGGEKRRVSIACELVTSPLVLFLDEPTSGLDASNANNVIECLVRLSSDYNRTLVLSIH 588

  Fly   244 QPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYHNPASYVIEVS--CGEHGD-- 304
            ||.:.:|.:||:|..|:.|:.||.|:.|::..||......||..:|.|.|:|:::  .|..|.
Yeast   589 QPRSNIFYLFDKLVLLSKGEMVYSGNAKKVSEFLRNEGYICPDNYNIADYLIDITFEAGPQGKRR 653

  Fly   305 HTRKLVDA--------IDN-------GKRDVRSSADYAGLKARNDLVKVQNLKAILDKNDASSVS 354
            ..|.:.|.        |||       ...|..:..::|.|.|..|.::    ..:.|:.|.....
Yeast   654 RIRNISDLEAGTDTNDIDNTIHQTTFTSSDGTTQREWAHLAAHRDEIR----SLLRDEEDVEGTD 714

  Fly   355 GRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSVNCTTALLTEEITSPER 419
            ||:....:.||..||:....|.|....:|..:......||...:|          |..::
Yeast   715 GRRGATEIDLNTKLLHDKYKDSVYYAELSQEIEEVLSEGDEESNV----------LNGDL----- 764

  Fly   420 YPTSQ-----FHQFWVVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGALYYDIGNDGAKVLSNLG 479
             ||.|     ..|..::..|:....||:..|:.......:|:...:|.|||::.||.:...:.:|
Yeast   765 -PTGQQSAGFLQQLSILNSRSFKNMYRNPKLLLGNYLLTILLSLFLGTLYYNVSNDISGFQNRMG 828

  Fly   480 FLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVAD-LPFQAIFCVIYVSI 543
            ..||.:.:..:.:.| .:.||.||..:.:||..|.:||..:||::..::: :|.:.:..::...|
Yeast   829 LFFFILTYFGFVTFT-GLSSFALERIIFIKERSNNYYSPLAYYISKIMSEVVPLRVVPPILLSLI 892

  Fly   544 VYYFTSQPWELFRFSMFLSACLL----ISFVAQSVGLVVGAAMNVQNGVFLAPVMSVPFLLFSGF 604
            ||..|....:...|...:...:|    ||....::|::.   .::.|.:.|:.::.:..|||||.
Yeast   893 VYPMTGLNMKDNAFFKCIGILILFNLGISLEILTIGIIF---EDLNNSIILSVLVLLGSLLFSGL 954

  Fly   605 FVSFDAIP-VYLRWITYLSYIRYGFEGTAL----------ATYGYGREKLRCFQTYCHFKSPITT 658
            |::...|. |..:::...|...|.:|...:          ..||...|           ....|.
Yeast   955 FINTKNITNVAFKYLKNFSVFYYAYESLLINEVKTLMLKERKYGLNIE-----------VPGATI 1008

  Fly   659 LEELDMVNANFTLDIVALIVIFVVLRISAYLFLRW 693
            |.....|..|...||..|.:..||..|..||.|:|
Yeast  1009 LSTFGFVVQNLVFDIKILALFNVVFLIMGYLALKW 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	90/243 (37%)
		3a01204	60..699	CDD:273361	188/681 (28%)
		ABC2_membrane	431..630	CDD:279410	48/204 (24%)
ADP1	NP_009937.2	EGF_CA	<70..>90	CDD:419698
ADP1	NP_009937.2	3a01204	402..1042	CDD:273361	186/674 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I2151
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm46658
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	8	7.740