DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and abcg2a

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_021325521.1	Gene:	abcg2a / 735312	ZFINID:	ZDB-GENE-050517-35	Length:	644	Species:	Danio rerio

Alignment Length:	612	Identity:	172/612 - (28%)
Similarity:	313/612 - (51%)	Gaps:	90/612 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PKRPAVDLAFHNLTY--RVKEG---NRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILS 99
            |.|....::|||:.|  ::|.|   ::|..|.||.|::|.::.| |.||:|.:|:|||:.|::|:
Zfish    26 PSRRGATVSFHNINYSLKMKSGFCKSKSTKKNILIGLNGIMKPG-LNAILGATGSGKSSFLDVLA 89

  Fly   100 GYK-TSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKH 163
            ..| .:.:.|.|.::||.:..: |:.||.|::||:.:.|.|||:|.:..:..|:|.|...:.||.
Zfish    90 ARKDPAGLSGEVLIDGAPQPPN-FKCLSGYVVQDDVVMGTLTVRENLRFSAALRLPKSIKQREKD 153

  Fly   164 SMIDDILLTLSLSEHRYT-----MTRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQ 223
            ..::.::..|.||:...:     :.|.:|||::||.:|.:||:.:||::|.||||:|||:||...
Zfish   154 EKVERLIQELGLSKVADSRVGTQLIRGVSGGERKRTNIGMELIIDPPVLFLDEPTTGLDASTANS 218

  Fly   224 CIHLLKMLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYH 288
            .:.|||.:...|||:|.:||||...::.:||.|..|..|:.||.|..:..:.:.|.:...|..::
Zfish   219 VLMLLKKMGNNGRTIILSIHQPRYSIYRLFDSLTLLVGGKLVYHGPAQDALSYFSQIGYTCEPHN 283

  Fly   289 NPASYVIEVSCGEHGDHTRKLVDAIDNGKRDVRSSADYAGLKARNDLVKVQNL-KAILDKNDASS 352
            |||.:.::|..|:                    |||           |.:..| :.::|::..||
Zfish   284 NPADFFLDVINGD--------------------SSA-----------VTLNKLYEEVVDQDQLSS 317

  Fly   353 VSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSV---NCTTALLTEEI 414
                           .|.|:.:.:|:|...||....|:      .|:::.|   :.:|...:..|
Zfish   318 ---------------SLKGIEDRLVEEYQRSSIFQQTH------ADLQRIVQGQDYSTRPKSRTI 361

  Fly   415 TSPERYPTSQFHQFWVVLKRTLLFSYRDWTL----MYLRLFAHLLVGFLIGALYYDIGNDGAKVL 475
            |    |.||..|||..|||||    :|:..|    ...::...:.:..::||:::.:..:.:.:.
Zfish   362 T----YSTSFCHQFHWVLKRT----FRNLMLNPQTSVAQIGVMIFLALVVGAIFFGVAENSSGIQ 418

  Fly   476 SNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVAD-LPFQAIFCVI 539
            :.:|.|||......::|::...| |..|..:.:.|..:.:|.:..|:|:..::| |..:.|..||
Zfish   419 NRMGALFFITTNQCFSSVSAAEL-FIAERKLFVHEYISGYYRVSVYFLSKILSDILTLRTIPAVI 482

  Fly   540 YVSIVYYFTSQPWELFRFSMFLSACLLISFVAQSVGLVVGAAMNVQNGVFLAPV-MSVPF---LL 600
            :..:.|:..........|.:||.:.:::|:.|.::.|.:.|...|   |.:|.: |::.|   ::
Zfish   483 FSCVAYFMIGLKPAAEAFFIFLFSIIMVSYTATAMTLAISADQTV---VAIANIFMTISFVFMMI 544

  Fly   601 FSGFFVSFDAIPVYLRWITYLSYIRYG 627
            |||..|:..::..:|.|:.|.|..|||
Zfish   545 FSGLLVNLPSVATWLNWLKYFSIPRYG 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	86/234 (37%)
		3a01204	60..699	CDD:273361	164/587 (28%)
		ABC2_membrane	431..630	CDD:279410	50/206 (24%)
abcg2a	XP_021325521.1	PRK10535	43..638	CDD:333000	166/595 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820