DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and ABCG8

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_011531331.1	Gene:	ABCG8 / 64241	HGNCID:	13887	Length:	677	Species:	Homo sapiens

Alignment Length:	704	Identity:	182/704 - (25%)
Similarity:	314/704 - (44%)	Gaps:	119/704 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QPKTLQHLPKRPAVDLA-----FHNLT-YRV---KEGNRSNAKTILKGVSGRLRSGELTAIMGPS 87
            ||.||:.......||||     |..|. :::   ....:::.:..::.:|.::|||::.||:|.|
Human    47 QPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSS 111

  Fly    88 GAGKSTLLNILSGY----KTSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVA 148
            |.|:::||::::|.    |..|  |.:.:||...:....||..|::.|.|||..||||:|.:...
Human   112 GCGRASLLDVITGRGHGGKIKS--GQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFI 174

  Fly   149 TNLKLSKKFSKPEKHSMIDDILLTLSLSEHRYT-----MTRNLSGGQKKRLSIALELVSNPPIMF 208
            ..::|.:.||:.::...::|::..|.|.:...|     ..|.||||:::|:||.::|:.||.|:.
Human   175 AQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILI 239

  Fly   209 FDEPTSGLDSSTCFQCIHLLKMLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQL 273
            .|||||||||.|....:..|..||.|.|.|:.::|||.:.:|.:||.:..:..|..:|.|:.:.:
Human   240 LDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHM 304

  Fly   274 VPFLSTLNLECPSYHNPASYVIEVSCGEHGDHTRKLVDAIDNGKRDVRSSADYAGLKARNDLVKV 338
            |.:.:.:...||.|.|||.:.::::             :||...|:..       |..|.   |.
Human   305 VQYFTAIGYPCPRYSNPADFYVDLT-------------SIDRRSREQE-------LATRE---KA 346

  Fly   339 QNLKAILDKNDASSVSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSV 403
            |:|.|:..:         |..|   |::.|......|:                 |....||.||
Human   347 QSLAALFLE---------KVRD---LDDFLWKAETKDL-----------------DEDTCVESSV 382

  Fly   404 NCTTALLTEEITSPERYPTSQFHQFWVVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGALYYDIG 468
               |.|.|..:.||.:.| ....||..:::|.:...:||...:.:......|:...||.||:..|
Human   383 ---TPLDTNCLPSPTKMP-GAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHG 443

  Fly   469 NDGAKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVADLPFQ 533
            :.....:.....||.....:.:..:...|.....|..:|..|..:..|:...|:.|..:.:||..
Human   444 SIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEH 508

  Fly   534 AIFCVIYVSIVYYFTS-----QPWELFRFSMFLSACLLISFVAQSVGLVVGAAM-NVQNGVFLAP 592
            ..:.:||....|:..:     ||:.|.    ||...|:: |..:.:.|...|.: ......|.:.
Human   509 CAYIIIYGMPTYWLANLRPGLQPFLLH----FLLVWLVV-FCCRIMALAAAALLPTFHMASFFSN 568

  Fly   593 VMSVPFLLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGYGREKLRCFQTYCHFKSP-- 655
            .:...|.|..||.::..::.....||:.:|::|:.|||  |....:.|      :||   |.|
Human   569 ALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEG--LMKIQFSR------RTY---KMPLG 622

  Fly   656 ----------ITTLEELDMVNANFTLDIVALIVI-----FVVLRISAYLFLRWK 694
                      |.::.|||    ::.|..:.||||     |:||...:..|::.|
Human   623 NLTIAVSGDKILSVMELD----SYPLYAIYLIVIGLSGGFMVLYYVSLRFIKQK 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	79/241 (33%)
		3a01204	60..699	CDD:273361	172/667 (26%)
		ABC2_membrane	431..630	CDD:279410	42/204 (21%)
ABCG8	XP_011531331.1	ABCG_White	64..299	CDD:213201	75/236 (32%)
		3a01204	92..667	CDD:273361	170/652 (26%)
		ABC2_membrane	406..610	CDD:279410	45/210 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3602
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.670