DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and abcg2b

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001034155.1	Gene:	abcg2b / 570453	ZFINID:	ZDB-GENE-050517-36	Length:	618	Species:	Danio rerio

Alignment Length:	707	Identity:	186/707 - (26%)
Similarity:	319/707 - (45%)	Gaps:	163/707 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KRPAVDLAFHNLTYRVKEG-----NRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSG 100
            |.|...|.:.|:.|.::|.     .::..:.|||.|||.:::| |.||||.:|:||::||::::|
Zfish    22 KVPGPILTYQNIHYCIRESRGLCCKKAPERDILKNVSGIMKTG-LNAIMGATGSGKTSLLDVMAG 85

  Fly   101 YK--TSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSK-KFSKPEK 162
            .|  .....|.|.::. :...|..|.:|||::||:.|.|.|||:|.:..:.||:|.: :||..:|
Zfish    86 RKDPRGLRSGQVLVDN-KLVTSDLRLMSAYVVQDDVLMGTLTVRENLLFSGNLRLPREQFSSADK 149

  Fly   163 HSMIDDILLTLSLSEHRYT-----MTRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCF 222
            ...::.|:..|.|.:...|     ..|.:|||::||.||.:||:::|.::|.||||:||||:|..
Zfish   150 KKKVESIIEELGLEDCADTKIGTEFIRGVSGGERKRCSIGMELITSPTLLFLDEPTTGLDSNTAN 214

  Fly   223 QCIHLLKMLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSY 287
            ..|.||..|:.||||:|.:||||...:|.:||.|..:..|:.||.|...:.:.:..:|..|..::
Zfish   215 SIIALLHRLSRGGRTIIFSIHQPRYSIFRLFDYLTLMHKGETVYAGPAGKAIDYFQSLGYERDAF 279

  Fly   288 HNPASYVIEVSCGEHGDHTRKLVDAIDNGKRDVRSSADYAGLKARNDLVKVQNLKAILDKNDASS 352
            :|||.:.::::.||                                               .|:|
Zfish   280 NNPADFFLDITNGE-----------------------------------------------TATS 297

  Fly   353 VSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSVNCTTA---LLTEEI 414
            :...|              .:.::.:|....:|             |::.:.|.|.   .|:|..
Zfish   298 MPTEK--------------SLAELYRESQFCTA-------------VDEELKCITGPSDSLSEAK 335

  Fly   415 TSPERYPTSQFHQFWVVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGALYYDIGNDGAKVLSN-L 478
            :....|.||..:|..||..||.|...|:....|.::..::|...|||.:||.:.....:.|.| :
Zfish   336 SKAPSYVTSFSYQLKVVCWRTGLNVVRNPQTSYAQIAMNILFALLIGLVYYQMPLTLPEALQNRI 400

  Fly   479 GFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVAD-LPFQAIFCVIYVS 542
            |..||.::.:::.:::...| |..|..:.:.||...:|....|:|:....| ||.:.:..:|:.|
Zfish   401 GAFFFLIINMVFGNLSAVEL-FINERAIFVHENSGGYYRTSVYFLSKVFVDLLPNRIVPILIFSS 464

  Fly   543 IVYY-------FTSQPWELFRFSMFLSACLLISFVAQSVGLVVGAAMNVQNGVFLAPVMSV-PF- 598
            |.||       |||       |..|.....|:|....|:..:|.|:::.   ..:|.::.| ||
Zfish   465 ISYYMMGLNPAFTS-------FLCFALTVSLVSLAGVSLAFLVSASVST---FAMANILVVLPFV 519

  Fly   599 --LLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGYGREKLRCFQTYCHFKSPITTLEE 661
              ::|.||.|:.:::..:|.|:.:.|..:||.:...                       |..::.
Zfish   520 FMMVFGGFLVNLNSMLNWLSWLKWTSIFKYGLDAVT-----------------------INEMKG 561

  Fly   662 LDMVNANFTL--------------------DIVALIVIFVVLRISAYLFL----RWK 694
            |.:.:.|.||                    :.|||:.|.:|....||:.|    |||
Zfish   562 LVLYSGNATLPGELYLESQGIDYSVWGFWQNEVALLGIVLVCMTFAYIQLRRINRWK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	89/236 (38%)
		3a01204	60..699	CDD:273361	180/683 (26%)
		ABC2_membrane	431..630	CDD:279410	56/211 (27%)
abcg2b	NP_001034155.1	P-loop_NTPase	39..260	CDD:304359	86/222 (39%)
		3a01204	41..616	CDD:273361	177/684 (26%)
		ABC2_membrane	354..557	CDD:279410	55/236 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750