DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3164 and abcg2c

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_005156580.1	Gene:	abcg2c / 569858	ZFINID:	ZDB-GENE-050517-37	Length:	640	Species:	Danio rerio

Alignment Length:	700	Identity:	186/700 - (26%)
Similarity:	334/700 - (47%)	Gaps:	138/700 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PAVDLAFHNLTYRVKE--GNRS---NAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSGYK 102
            |...:.||.:.||:||  |..|   ..|.|||.|||.:..| :.|||||:|:||::||::::|.|
Zfish    31 PGPTVTFHQIRYRIKERLGMFSCQWREKDILKDVSGIMNPG-MNAIMGPTGSGKTSLLDVIAGRK 94

  Fly   103 TSS--------IEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLS-KKFS 158
            ...        ::.::.       .|..|..|||::|::.|.|.|||:|.:..:.||:|| |::|
Zfish    95 DPKGLKSGQVLVDNTIV-------TSDLRLCSAYVVQNDILMGTLTVRENLAFSANLRLSLKEYS 152

  Fly   159 KPEKHSMIDDILLTLSLSEHRYT-----MTRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDS 218
            ..:|...::.::..|.|.:...|     ..|.:|||:|||.||.:||:::|.::|.||||:|||:
Zfish   153 SSDKEMRVNSVIQELGLKDCADTKIGTMFLRGVSGGEKKRCSIGMELITSPSLLFLDEPTTGLDA 217

  Fly   219 STCFQCIHLLKMLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLE 283
            :|....:.||:.::..|:|||.:||||...:|..||.|..:..|:.:|.|:..:.:.:...|..:
Zfish   218 NTANSIMELLQNISKKGKTVIFSIHQPRYSIFRQFDHLTLMNKGEIIYAGAADKAIIYFEDLGYK 282

  Fly   284 CPSYHNPASYVIEVSCGEHGDHTRKLVDAIDNGKRDVRSSADYAGLKARNDL-VKVQNLKAILDK 347
            |..::|||.:.::|:.|....|                        |:.|:: .|..:.:.::|.
Zfish   283 CEPFNNPADFFLDVTNGTIRPH------------------------KSSNNISEKCSSSEEMVDN 323

  Fly   348 NDASSVSGR------KYEDNLT-LNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSVNC 405
            .:..:|..|      |.:|.|| :::|
Zfish   324 ENPLAVMYRKSPYFTKLKDRLTEISDG-------------------------------------- 350

  Fly   406 TTALLTEEITSPER--YPTSQFHQFWVVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGALYYDIG 468
                |..|:|..::  |.|..::|..:|..||:....|:....|.:||.::..|.|:|.:||.|.
Zfish   351 ----LDPEVTKGDKIGYATPFYYQLLLVSGRTIRNILRNPQTSYAQLFLNIFFGILVGLIYYQIP 411

  Fly   469 NDGAKVLSN-LGFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVADL-P 531
            :...:.|.| .|..||.::.:::.:::...| |..|..:.:.||.:.:|...:|:|:...||| |
Zfish   412 HTLPEALQNRTGAFFFLVINMVFGNLSAVEL-FVSERELFIHENSSGFYRTSAYFLSKVFADLIP 475

  Fly   532 FQAIFCVIYVSIVYYFTSQPWELFRFSMFLSACLLISFVAQSVGLVVGAAMNVQNGVF-LAPVM- 594
            .:.:...|:.:|.|:......|:..|.::.....::|..|.|:..:|.|::    |.| :|.::
Zfish   476 NRILPVFIFSAIPYFMMGLKPEVEAFFLYCVTMSMVSLSAVSLAFLVSASV----GSFAMANILI 536

  Fly   595 SVPF---LLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGYGREKLRCFQTYCHFKSPI 656
            ::|:   ::|.||.|:.:::...|.|:.:.|..|||:...|:...   ::::        |...:
Zfish   537 ALPYVFMMVFGGFLVNLNSMLSGLSWLKWASIFRYGYNALAINEL---KDQV--------FTDNL 590

  Fly   657 TTL--------EELDMVNANFTLDIVALIVIFVVLRISAYLFL----RWK 694
            |.:        :|:|.....|..:.|||..|..|..|.||:.|    |||
Zfish   591 TRVTGDMYLDHQEIDRSAWGFWENQVALAGIMFVCLILAYVQLCRINRWK 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	87/242 (36%)
		3a01204	60..699	CDD:273361	177/680 (26%)
		ABC2_membrane	431..630	CDD:279410	54/205 (26%)
abcg2c	XP_005156580.1	ABCG_EPDR	34..267	CDD:213180	87/240 (36%)
		3a01204	37..638	CDD:273361	182/690 (26%)
		ABC2_membrane	377..579	CDD:279410	54/206 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750