DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and abcg4a

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_687685.2	Gene:	abcg4a / 564842	ZFINID:	ZDB-GENE-050517-39	Length:	641	Species:	Danio rerio

Alignment Length:	682	Identity:	308/682 - (45%)
Similarity:	426/682 - (62%)	Gaps:	78/682 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QLKAQIVPAQPKTLQHLPKRPAVDLAFHNLTYRVKEG---NRSNAKTILKGVSGRLRSGELTAIM 84
            :::..|..||  ...|||:|..|||.|..|:|.::||   .|...|.:||.:||:..|.||..||
Zfish    33 KVENHITEAQ--RFSHLPRRSTVDLEFTELSYTIREGPCWRRRGFKALLKCLSGKFCSRELIGIM 95

  Fly    85 GPSGAGKSTLLNILSGYKTSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVAT 149
            ||||||||||:|||:||:.:.::|.:.:||..|:|..|||:|.|||||:.|..:||.:|||.|:.
Zfish    96 GPSGAGKSTLMNILAGYRETGMKGQILVNGRPRDLRTFRKMSCYIMQDDMLLPHLTTREAMMVSA 160

  Fly   150 NLKLSKKFSKPEKHSMIDDILLTLSLSEHRYTMTRNLSGGQKKRLSIALELVSNPPIMFFDEPTS 214
            ||||::...  .|..::::||..|.|.|...|.|.:|||||.|||:||||||:|||:||||||||
Zfish   161 NLKLNENME--VKKELVNEILTALGLQECAQTRTISLSGGQCKRLAIALELVNNPPVMFFDEPTS 223

  Fly   215 GLDSSTCFQCIHLLKMLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLST 279
            ||||::|||.:.|:|.||.||||:|||||||||:||||||:||.|:.|||:|:|:...|:|:|..
Zfish   224 GLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIYKGTVPYLIPYLKN 288

  Fly   280 LNLECPSYHNPASYVIEVSCGEHGDHTRKLVDAIDNGKRDVRSSADYAGLKARNDLVKVQNLKAI 344
            |.|.||:|||||.::|||:.||:||....|.:|:..|                  |....:.|..
Zfish   289 LGLHCPTYHNPADFIIEVASGEYGDLNPVLFEAVQGG------------------LCSDDSKKNS 335

  Fly   345 LDKND-ASSVSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMIDVEKSVNCTTA 408
            .|||| .:|...:.|.|         :|.                          :||
Zfish   336 SDKNDPTTSCPSQCYPD---------SGY--------------------------IEK------- 358

  Fly   409 LLTEEITSPERYPTSQFHQFWVVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGALYYDIGNDGAK 473
                     ..:.||...||.::.|||.:...||..|.:||:.:||.:|.|||.||.:||||.:|
Zfish   359 ---------HTFATSTLTQFCILFKRTFITICRDVVLTHLRVMSHLCIGVLIGLLYLNIGNDASK 414

  Fly   474 VLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVADLPFQAIFCV 538
            |.:|.|||||:|||||:.::..|:|:|||||.|.::|:.|.|||||:||||.::||:|||.|..:
Zfish   415 VFNNTGFLFFSMLFLMFAALMPTVLTFPLEMGVFIREHLNYWYSLKAYYLAKTMADIPFQVICPI 479

  Fly   539 IYVSIVYYFTSQPWELFRFSMFLSACLLISFVAQSVGLVVGAA-MNVQNGVFLAPVMSVPFLLFS 602
            :|.||||:.|.||.|..|:.:|::.....:.||||:||::||| .::|...|:.||.::|.||||
Zfish   480 MYCSIVYWMTEQPPEAGRYLLFMALSTSTALVAQSLGLLIGAASTSLQVATFVGPVSAIPVLLFS 544

  Fly   603 GFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGYGREKLRCFQTYCHFKSPITTLEELDMVNA 667
            ||||:||.||.||:|.:|:||:||||||..|:.||..|.:|.|....|.|:.|...|:.||:.:|
Zfish   545 GFFVNFDTIPKYLQWSSYVSYVRYGFEGVILSIYGMNRSELECPGIVCKFQKPEEVLQLLDVEDA 609

  Fly   668 NFTLDIVALIVIFVVLRISAYLFLRWKLKTVR 699
            ...:|.:.|.|.|:|||::.|..||:|:|:.|
Zfish   610 KLYVDFMVLGVFFLVLRLATYFVLRYKVKSER 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	129/226 (57%)
		3a01204	60..699	CDD:273361	292/640 (46%)
		ABC2_membrane	431..630	CDD:279410	105/199 (53%)
abcg4a	XP_687685.2	3a01204	38..641	CDD:273361	307/675 (45%)
		ABCG_EPDR	53..277	CDD:213180	129/225 (57%)
		ABC2_membrane	372..574	CDD:279410	107/201 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11201
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		otm25175
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.950