DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and abcg5

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001122162.1	Gene:	abcg5 / 557317	ZFINID:	ZDB-GENE-050517-40	Length:	652	Species:	Danio rerio

Alignment Length:	671	Identity:	175/671 - (26%)
Similarity:	298/671 - (44%)	Gaps:	120/671 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NQYSWKQFLENNNLLGTAGAGQLKAQIVPAQPKTLQHLPK--RPAVDLAFHNLTYRVKEG----- 59
            :.||.|..::.|.|.|:..        |.::.:|.:..|.  .|:..|:..|::|.|.|.
Zfish     3 HSYSMKDVVQKNGLNGSFK--------VVSEMETARSNPDYIEPSSCLSVKNVSYSVSERVGPWW 59

  Fly    60 -----NRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSGY--KTSSIEGSVTMNGAER 117
                 .:...:.||..||..|.||::..|:|.||:||:|||:.::|.  .:.:::|.|.:||.:.
Zfish    60 DLSSFRKKWTRQILNEVSFHLDSGQIMGILGNSGSGKTTLLDAIAGRIGNSGNLQGEVFVNGRKL 124

  Fly   118 NLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHSMIDDILLTLSLSEHRYTM 182
            ....|:...:|::|.:.|...|||:|.:|....|.| :|.|.......:..::..|||....:::
Zfish   125 KREQFQDCFSYVLQSDNLLSYLTVEETLTYTAQLAL-RKHSAEAIRKKVTAVMAELSLGHVAHSV 188

  Fly   183 T-----RNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCIHLLKMLAAGGRTVICTI 242
            .     ..:|||:::|:|||.:|:.:|.::..||||:||||.|..|.:.||..||...|.||.||
Zfish   189 IGGRVFPGISGGERRRVSIASQLLQDPKVILLDEPTTGLDSMTANQIVMLLAELARRDRIVIVTI 253

  Fly   243 HQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYHNPAS-YV----IEVSCGEH 302
            |||.:.||.:|:::..::.|:.|:.|...::|.|.|:...|||.|.||.. ||    ::..|.|
Zfish   254 HQPRSELFRIFNRIAIMSQGELVFCGEPHKMVDFFSSCGYECPEYCNPFDIYVDLTSVDTRCSE- 317

  Fly   303 GDHTRKLVDAIDNGKRDVRSSADYAGLKARNDLVKVQNLKAILDKNDASSVSGRKYEDNLTLNNG 367
                              |.:|.|                             |:..|   :.:.
Zfish   318 ------------------REAATY-----------------------------RRMHD---ITSA 332

  Fly   368 LLNGMVNDIVKEGNVSSALVTTNERGD-AMIDV--EKSVNCTTALLTEEITSPERYPTSQFHQFW 429
            ..|..:..     |:...:..:.:|.| .||..  ::|.||.:.|                   .
Zfish   333 YQNSEIYT-----NMQEKIEQSCQRPDKPMIPFKSKESPNCISKL-------------------G 373

  Fly   430 VVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGALYYDIGNDGAK--VLSNLGFLFFNMLFLMYTS 492
            |:|:||.....||...:.:||..:|:.|..|......:|.|..|  |...:|.::.:|....||.
Zfish   374 VLLRRTFRNVSRDRMGILMRLSQNLIYGLFIAFFLMRLGKDVTKGAVQDRIGLIYQSMGASPYTG 438

  Fly   493 MTITILSFPLEMPVLLKENFNRWYSLKSYYLAISVADLPFQAIFCVIYVSIVYYFTSQPWELFRF 557
            |...:..||....:..:|:.:..|.....:||..:..|||..|...|:.|.:|:......:..||
Zfish   439 MLNAVALFPALRAISDQESKDGLYQKWQMFLAYIIHILPFSIISVFIFASFLYWTVGMNPDPVRF 503

  Fly   558 SMFLSACLLISFVAQSVGLV-VGAAMN---VQNGVFLAPVMSVPFLLFSGFFVSFDAIPVYLRWI 618
            ..|.:..::...:.:.:.|| :|...:   |.:||.|..:..:  ::.|||...|..:||..:|:
Zfish   504 LCFSAVVMVPHIIGELLTLVLLGVVQDPNMVNSGVALLNIAGI--MVGSGFLRGFKQMPVVFQWL 566

  Fly   619 TYLSYIRYGFEGTALATYGYG 639
            :||::.:||.| ..:.|..||
Zfish   567 SYLTFQKYGCE-LLIVTEFYG 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	78/240 (33%)
		3a01204	60..699	CDD:273361	160/601 (27%)
		ABC2_membrane	431..630	CDD:279410	53/204 (26%)
abcg5	NP_001122162.1	3a01204	50..645	CDD:273361	162/616 (26%)
		ABCG_White	53..279	CDD:213201	74/226 (33%)
		ABC2_membrane	375..582	CDD:279410	54/209 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820