DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and CG17646

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_608618.1	Gene:	CG17646 / 33354	FlyBaseID:	FBgn0264494	Length:	766	Species:	Drosophila melanogaster

Alignment Length:	699	Identity:	256/699 - (36%)
Similarity:	386/699 - (55%)	Gaps:	87/699 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VDLAFHNLTYRVKE----GNRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSGYKTSS 105
            ||:.|.::.|.||:    ..:...|.||.|::|..|||||||||||||||||||||::||:.::.
  Fly   104 VDIQFADVRYTVKKFSFPERKFVTKEILHGLNGSFRSGELTAIMGPSGAGKSTLLNVMSGFCSTG 168

  Fly   106 IEGSVTMN------GAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHS 164
            :.|.:.:|      .:||    ||::..||.||:.|...|.|.|.|.:|.:|||..|.:|..|..
  Fly   169 VSGDIRVNRKPMAPSSER----FRQMLCYIHQDDLLRPQLLVGEIMLLAAHLKLGFKVTKAYKMD 229

  Fly   165 MIDDILLTLSLSEHRYTM-TRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCIHLL 228
            :|..||..|.| :|||.: |..|||||||||:|||||:||||:::.||||:|||||:|..|:.||
  Fly   230 LIKHILSLLGL-DHRYNVPTGKLSGGQKKRLAIALELISNPPVLYLDEPTTGLDSSSCSSCVALL 293

  Fly   229 KMLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYHNPASY 293
            |.||:.|.|::||||||||.:|||||:|||:.||.|:|||..::|||||:...|.||||||||.|
  Fly   294 KKLASQGHTIVCTIHQPSALIFEMFDKLYTVVDGHCMYQGPVRELVPFLADQQLVCPSYHNPADY 358

  Fly   294 VIEVSCGEH--------------------------GDHTRKLVDAID---NGKRDVRSSADYAGL 329
            ::||:.|||                          .|...:||::|.   .||..|::|...|..
  Fly   359 LLEVAVGEHQRDLNELIHAANKKYYEDVDRHRYMSSDDMARLVESIKENMGGKAVVKTSEALAAF 423

  Fly   330 KARN----DLVKVQNLKAILDKNDASSVSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTN 390
            .|..    |.||....:..|::..|.|......:.:|...|  |......:.|.|.::
  Fly   424 AAAQFSSFDYVKPSPQELALEEIKALSGGPESADPDLLEKN--LRPQPQPLAKAGELA------- 479

  Fly   391 ERGDAMIDVEKSVNCTTALLTEEITSPERYPTSQF-HQFWVVLKRTLLFSYRDWTLMYLRLFAHL 454
                                    ..|....::.| .|:.::::|.|:.:.|::.|:..|:|:|:
  Fly   480 ------------------------RPPNAIRSASFLMQYVLLMQRILICAKRNYFLLLARIFSHI 520

  Fly   455 LVGFLIGALYYDIGNDGAKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLK 519
            .:|.:.|.||.::||:...||.|..:|:.:.|.|:||.....:|:||||:.:|.:|:|||||.|.
  Fly   521 FIGVVFGYLYMNVGNNAQSVLGNYVYLYGSTLLLVYTGKMAVVLTFPLEIDMLTREHFNRWYKLG 585

  Fly   520 SYYLAISVADLPFQAIFCVIYVSIVYYFT-SQPWELFRFSMFLSACLLISFVAQSVGLVVGAAMN 583
            .|:|::...::|||::...:|:.|..:.| :...:.||...|:...::.|..||:.|..|||.:.
  Fly   586 PYFLSLISFEIPFQSLCTAMYIIISVHLTGNDATDSFRIYYFMLLGIMASLSAQAWGFFVGATLP 650

  Fly   584 VQNGVFLAPVMSVPFLLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGYGREKLRCFQT 648
            .:..|||.|:::|.|.:| ||...:..|....||:.:|||.|.||.|...|.||..|..|.|.:|
  Fly   651 TKLAVFLGPILAVMFSVF-GFCTRYIDITPLFRWMWHLSYFRAGFHGALNAIYGMDRPFLECPET 714

  Fly   649 --YCHFKSPITTLEELDMVNANFTLDIVALIVIFVVLRISAYLFLRWKL 695
              ||||:||...|:.:.:.:.:.:..::.:.::..|:.:...:.|..||
  Fly   715 AMYCHFRSPKVFLKYMMISDVHMSDCLILMGIVIGVMHVLTLITLWHKL 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	121/233 (52%)
		3a01204	60..699	CDD:273361	250/680 (37%)
		ABC2_membrane	431..630	CDD:279410	70/199 (35%)
CG17646	NP_608618.1	ABCG_EPDR	103..333	CDD:213180	121/233 (52%)
		3a01204	123..765	CDD:273361	250/680 (37%)
		ABC2_membrane	497..698	CDD:279410	71/201 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I1855
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm14984
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	8	7.920