DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and Abcg5

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_114090.1	Gene:	Abcg5 / 27409	MGIID:	1351659	Length:	652	Species:	Mus musculus

Alignment Length:	673	Identity:	167/673 - (24%)
Similarity:	297/673 - (44%)	Gaps:	110/673 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YRVKEGNRSNAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSG--YKTSSIEGSVTMNGAE 116
            :.:|...:...:.|||.||..:.||::..|:|.||:||:|||:.:||  .:|.::||.|.:||.|
Mouse    56 WNIKSCQQKWDRQILKDVSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCE 120

  Fly   117 RNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHSMIDDILLTLSLSEHRYT 181
            .....|:...:|::|.:....:|||:|.:.....|.|.:. |....:..::.::..||||.....
Mouse   121 LRRDQFQDCFSYVLQSDVFLSSLTVRETLRYTAMLALCRS-SADFYNKKVEAVMTELSLSHVADQ 184

  Fly   182 MTRN-----LSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCIHLLKMLAAGGRTVICT 241
            |..:     :|.|:::|:|||.:|:.:|.:|..||||:|||..|..|.:.||..||...|.||.|
Mouse   185 MIGSYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANQIVLLLAELARRDRIVIVT 249

  Fly   242 IHQPSARLFEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYHNPASYVIEVSCGEHGDHT 306
            ||||.:.||:.||::..|..|:.|:.|:.::::.|.:.....||.:.||..:.::::
Mouse   250 IHQPRSELFQHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLT-------- 306

  Fly   307 RKLVDAIDNGKRDVRSSADYAGLKARNDLVKVQNLKAILDKNDASSVSGRKYEDNLTLNNGLLNG 371
                 ::|...|: |....|.         :||.|:...
Mouse   307 -----SVDTQSRE-REIETYK---------RVQMLECAF-------------------------- 330

  Fly   372 MVNDIVKEGNVSSALVTTNERGDAMIDVEKSVNCTTALLTEEITSPERYPTSQFHQFWVVLKRTL 436
                  ||.::...::...||...:..:.     |....|::       |...|.:..|:|:|..
Mouse   331 ------KESDIYHKILENIERARYLKTLP-----TVPFKTKD-------PPGMFGKLGVLLRRVT 377

  Fly   437 LFSYRDWTLMYLRLFAHLLVGFLIGALYYDIGNDGAK--VLSNLGFLFFNMLFLMYTSMTITILS 499
            ....|:...:.:||..:|::|..:......:.|:..|  |...:|.|:..:....||.|...:..
Mouse   378 RNLMRNKQAVIMRLVQNLIMGLFLIFYLLRVQNNTLKGAVQDRVGLLYQLVGATPYTGMLNAVNL 442

  Fly   500 FPLEMPVLLKEN----FNRWYSLKSYYLAISVADLPFQAIFCVIYVSIVYYFTSQPWELFRFSMF 560
            ||:...|..:|:    :::|..|.:|.|.:    |||..|..||:.|:.|:......|:.||..|
Mouse   443 FPMLRAVSDQESQDGLYHKWQMLLAYVLHV----LPFSVIATVIFSSVCYWTLGLYPEVARFGYF 503

  Fly   561 LSACLLISFVAQSVGLVVGAAM---NVQNGVFLAPVMSVPFLLF-SGFFVSFDAIPVYLRWITYL 621
            .:|.|....:.:.:.||:...:   |:.|.:  ..::|:..||. |||..:...:|:.|:.:.|.
Mouse   504 SAALLAPHLIGEFLTLVLLGIVQNPNIVNSI--VALLSISGLLIGSGFIRNIQEMPIPLKILGYF 566

  Fly   622 SYIRY--------GFEGTALATYGYGREKLRCFQTYCHFKSPITTLEE-----LDMVNANFTL-- 671
            ::.:|        .|.|......|.....|.  ...|.....:..:|:     .....|||.:
Mouse   567 TFQKYCCEILVVNEFYGLNFTCGGSNTSMLN--HPMCAITQGVQFIEKTCPGATSRFTANFLILY 629

  Fly   672 -DIVALIVI-FVVLRISAYLFLR 692
             .|.||::: .|:.::..||..|
Mouse   630 GFIPALVILGIVIFKVRDYLISR 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	78/220 (35%)
		3a01204	60..699	CDD:273361	166/667 (25%)
		ABC2_membrane	431..630	CDD:279410	52/216 (24%)
Abcg5	NP_114090.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		ABCG_White	50..276	CDD:213201	78/220 (35%)
		3a01204	61..646	CDD:273361	163/660 (25%)
		ABC2_membrane	372..579	CDD:279410	51/212 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820