DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and Abcg2

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_001342406.1	Gene:	Abcg2 / 26357	MGIID:	1347061	Length:	657	Species:	Mus musculus

Alignment Length:	709	Identity:	193/709 - (27%)
Similarity:	340/709 - (47%)	Gaps:	107/709 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IVPAQPKTLQHLPK------RPAVD---LAFHNLTYRVKEGN-----RSNAKTILKGVSGRLRSG 78
            :||...:....||:      |...:   |:||::|||||..:     ::..|.||..::|.::.|
Mouse     9 LVPMSQRNNNGLPRMNSRAVRTLAEGDVLSFHHITYRVKVKSGFLVRKTVEKEILSDINGIMKPG 73

  Fly    79 ELTAIMGPSGAGKSTLLNILSGYK-TSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQ 142
             |.||:||:|.|||:||::|:..| ...:.|.|.:|||.:. :.|:..|.|::||:.:.|.|||:
Mouse    74 -LNAILGPTGGGKSSLLDVLAARKDPKGLSGDVLINGAPQP-AHFKCCSGYVVQDDVVMGTLTVR 136

  Fly   143 EAMTVATNLKLSKKFSKPEKHSMIDDILLTLSL-----SEHRYTMTRNLSGGQKKRLSIALELVS 202
            |.:..:..|:|.......||:..|:.|:..|.|     |:......|.:|||::||.||.:||::
Mouse   137 ENLQFSAALRLPTTMKNHEKNERINTIIKELGLEKVADSKVGTQFIRGISGGERKRTSIGMELIT 201

  Fly   203 NPPIMFFDEPTSGLDSSTCFQCIHLLKMLAAGGRTVICTIHQPSARLFEMFDQLYTLADGQCVYQ 267
            :|.|:|.||||:||||||....:.|||.::..|||:|.:||||...:|::||.|..||.|:.|:.
Mouse   202 DPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLVFH 266

  Fly   268 GSTKQLVPFLSTLNLECPSYHNPASYVIEVSCGEHGDHTRKLVDAIDNGKRDVRSSADYAGLKAR 332
            |..::.:.:.::....|..|:|||.:.::|.   :||.:..:::         |...|
Mouse   267 GPAQKALEYFASAGYHCEPYNNPADFFLDVI---NGDSSAVMLN---------REEQD------- 312

  Fly   333 NDLVKVQNLKAILDKNDASSVSGRKYEDNLTLNNGLLNGMVNDIVKEGNVSSALVTTNERGDAMI 397
            |:          .:|.:..|...:...:||:               |..::||:.     |:...
Mouse   313 NE----------ANKTEEPSKGEKPVIENLS---------------EFYINSAIY-----GETKA 347

  Fly   398 DVEKSVNCTTALLTEEITSPERYPTSQFHQFWVVLKRTLLFSYRDWTLMYLRLFAHLLVGFLIGA 462
            ::::.........|.....|. |.||..||...:.:|:......:......:|...:::|.:|||
Mouse   348 ELDQLPGAQEKKGTSAFKEPV-YVTSFCHQLRWIARRSFKNLLGNPQASVAQLIVTVILGLIIGA 411

  Fly   463 LYYDIGNDGAKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLKENFNRWYSLKSYYLAISV 527
            :|:|:..|.|.:.:..|.|||......::|::...| |.:|..:.:.|..:.:|.:.||:....:
Mouse   412 IYFDLKYDAAGMQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYISGYYRVSSYFFGKVM 475

  Fly   528 AD-LPFQAIFCVIYVSIVYYFTSQPWELFRFSMFLSACLLISFVAQSVGLVVGAAMNVQNGVFLA 591
            :| ||.:.:..||:..|:|:.......:..|.:.:...:::::.|.|:.|.:....:|.:...|
Mouse   476 SDLLPMRFLPSVIFTCILYFMLGLKKTVDAFFIMMFTLIMVAYTASSMALAIATGQSVVSVATL- 539

  Fly   592 PVMSVPF---LLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGY-GRE---------KL 643
             :|::.|   :||||..|:...|..:|.|:.|.|..||||  |||....: |:|         ..
Mouse   540 -LMTIAFVFMMLFSGLLVNLRTIGPWLSWLQYFSIPRYGF--TALQYNEFLGQEFCPGFNVTDNS 601

  Fly   644 RCFQTYCHFKSPITTLEELDMVNANFTLD----------IVALIVIFVVLRISAYLFLR 692
            .|..:|.     |.|..|. ::|....|.          :..:|:||:.:.....|||:
Mouse   602 TCVNSYA-----ICTGNEY-LINQGIELSPWGLWKNHVALACMIIIFLTIAYLKLLFLK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	92/237 (39%)
		3a01204	60..699	CDD:273361	180/668 (27%)
		ABC2_membrane	431..630	CDD:279410	51/202 (25%)
Abcg2	NP_001342406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		4/14 (29%)
Abcg2	NP_001342406.1	3a01204	46..651	CDD:273361	179/667 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R138
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750