DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and wht-3

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_497825.2	Gene:	wht-3 / 175528	WormBaseID:	WBGene00007631	Length:	614	Species:	Caenorhabditis elegans

Alignment Length:	658	Identity:	172/658 - (26%)
Similarity:	289/658 - (43%)	Gaps:	130/658 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILSGYKTSSIE--GSVTMNGAE--RNLSAFRKL 125
            |.:|..|||..:.||:.|:||.|||||:||:|:|.......:|  |:|.:||.:  :.:|.   :
Worm    58 KQLLNRVSGIAKPGEMVALMGASGAGKTTLMNVLMCRNMKGLEKNGTVKVNGTKIGKEISL---I 119

  Fly   126 SAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKHSMIDDILLTLSLSEHRYT------MTR 184
            |.:..|.......|||.|.:.:...|::  |.:|..:...:|:|:..|.|...|..      :.:
Worm   120 SGFAQQQEIFIPTLTVDEYLMIQARLRM--KANKHTRRERVDEIIEMLRLQNCRDLKIGTPGLVK 182

  Fly   185 NLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCIHLLKMLAAGGRTVICTIHQPSARL 249
            .:|||:.:||:.|.||:|||.::|.|||||||||......:.:||.||..|||:   ||||:|.|
Worm   183 GISGGEARRLTFACELLSNPSLLFADEPTSGLDSFMAASVVQILKNLANSGRTL---IHQPTAEL 244

  Fly   250 FEMFDQLYTLADGQCVYQGSTKQLVPFLSTLNLECPSYHNPASYVIEVSCGEHGDHTRKLVDAID 314
            |..||::..|:.|:..:.|:..:.|.|.:......|...||..::            :..:..|.
Worm   245 FFQFDKIIFLSMGKTAFMGTPHESVKFFADCGHPIPKLFNPPEWI------------QSKLSVIP 297

  Fly   315 NGKRDVRSSADYAGLKARNDLVKVQNLKAILDKNDASSVSGRKYEDNLTLNNGLLNGMVNDIVKE 379
            |.:           .|:|..:.|:...                ||.::             |.::
Worm   298 NNE-----------TKSRETIGKIIEF----------------YEKSI-------------IHQK 322

  Fly   380 GNVSSALVTTNERGDAMIDVEKSVNCTTALLTEEITSPERYPTSQFHQFWVVLKRTLLFSYRDWT 444
            ..|...::.|.|                  |...|.:|     ..|.:...:|||..|...|...
Worm   323 SIVEIRVIATTE------------------LPPYIENP-----GFFAETGALLKRACLDVIRSPA 364

  Fly   445 LMYLRLFAHLLVGFLIGALYYDIGNDGAKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLLK 509
            .|.::|...:::|..||:||:....|...|.:....|:|.:..|.:::|...:.....|:|::.:
Worm   365 QMRMKLIQKVVMGLFIGSLYWQQPLDPRGVRNTNSALYFLIAELTFSTMFGIMTFMEHELPLIAR 429

  Fly   510 ENFNRWYSLKSYYLAISVADLPFQAIFCVIYVSIVYYF--TSQPWELFRFSMFLSACLLISFVAQ 572
            |..:..:.:.|||::..::.||...|...:.:.|.|:.  .:..|:....|:.:|  :|:...|.
Worm   430 EYHDGLFYVISYYISRFLSYLPLFTIDGALMIVISYWMIGLNSTWQQVAKSILIS--VLVEQSAT 492

  Fly   573 SVGLVVGAAMNVQNGVFLAPVMSVP----FLLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTAL 633
            |.||.:.......:   ||...:||    |.|.||.:.:.:..|||:||:.:.|:.||||||..:
Worm   493 SCGLFLACLFETTS---LAIAFAVPASGLFALLSGLYGNTNNFPVYIRWMQWTSWCRYGFEGLVV 554

  Fly   634 ATYG---------YGREKLRCFQTYCHFKSPITTLEELDMVNANFTLDIVAL--IVIFVVLRISA 687
            ..:.         :.||.:               |::......|:.||::.|  ||||..|....
Worm   555 NQWSQVDNPKWDPFYRELI---------------LKQFSFNKDNYQLDVIGLCSIVIFFYLAGYI 604

  Fly   688 YLFLRWKL 695
            .||:|.:|
Worm   605 ALFIRIRL 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	78/212 (37%)
		3a01204	60..699	CDD:273361	172/658 (26%)
		ABC2_membrane	431..630	CDD:279410	55/204 (27%)
wht-3	NP_497825.2	ABCG_EPDR	36..263	CDD:213180	78/212 (37%)
		3a01204	37..614	CDD:273361	172/658 (26%)
		ABC2_membrane	351..555	CDD:279410	57/208 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3602
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100076
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.670