DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3164 and abt-2

DIOPT Version :9

Sequence 1:	NP_722605.1	Gene:	CG3164 / 33171	FlyBaseID:	FBgn0025683	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_490949.3	Gene:	abt-2 / 171782	WormBaseID:	WBGene00000020	Length:	2146	Species:	Caenorhabditis elegans

Alignment Length:	954	Identity:	185/954 - (19%)
Similarity:	293/954 - (30%)	Gaps:	375/954 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LPKRPAVDLAFHNLTYRVKEGNRS----NAKTILKGVSGRLRSGELTAIMGPSGAGKSTLLNILS 99
            :|...:.|....|||..|...:.|    |....|..::.||..|::|.::|.:||||:|.::||.
Worm   912 IPNSDSFDSEPTNLTLAVHINSMSKVYENGTKALDCLNLRLYEGQITGLLGHNGAGKTTTMSILC 976

  Fly   100 G-YKTSSIEGSVTMNGAERNLSAFRKLSAYIMQDNQLHGNLTVQEAMTVATNLKLSKKFSKPEKH 163
            | |..||....:.......:|...|.:.....|.|.|..:|||.|.:.:...||     ..|:..
Worm   977 GLYAPSSGTAKIYQRDIRTDLRRVRDVLGICPQHNVLFSHLTVSEQLRLFAALK-----GVPDSE 1036

  Fly   164 --SMIDDILLTLSLSEHRYTMTRNLSGGQKKRLSIALELVSNPPIMFFDEPTSGLDSSTCFQCIH 226
              |.:|:||.::||:|....:...||||.|:||.|.:..:.....:..||||:|:| .|..:.|.
Worm  1037 LTSQVDEILASVSLTEKANKLASTLSGGMKRRLCIGIAFIGGSRFVILDEPTAGVD-VTARKDIW 1100

  Fly   227 LLKMLAAGGRTVICTIHQP------SARL------FE----------MFDQLYTLADGQCVYQGS 269
            .|......|||::.:.|..      |.|:      ||          :|...|.|...:..|...
Worm  1101 KLLQRNKEGRTILLSTHHMDEADVLSDRIAILSQDFEKPDLLDGKRLIFQHFYALLVCRINYTLK 1165

  Fly   270 TKQ------LVP-FLSTLN----LECPSYHNPASYV------IEVS-CGEHGDHTRKLVDAIDNG 316
            :|:      ::| ||..|.    |...|...|...|      :|.| .|.|.|......|..:|.
Worm  1166 SKRTFLFQVIIPLFLLALAELFVLLQVSTARPDLMVSMPPLPLETSIMGNHSDFYVNSWDTAENS 1230

  Fly   317 KRD--VRSSADYAGLKAR------NDLV---------------------------------KVQN 340
            ..:  :.:.....|...|      |||:                                 :.||
Worm  1231 TANDILHAMFSSPGTGPRCAKDVPNDLLDTMRRELMFRNRYGFGRNKPAPGVDKDSVDNEYQCQN 1295

  Fly   341 LKAILDKNDASSVSGRKY--------ED---NLTLNNGLLN----------GMVNDIVKEGNVSS 384
            ::...|..:  .:|...|        ||   |.||.:...|          ..:.|:........
Worm  1296 IQGEFDYTE--DISNATYNAPIYCGCEDFGWNCTLEDWKWNETNWLRLNTTDRIFDLTGRNLTQF 1358

  Fly   385 ALVT---------------------TNERGDAMIDVEKS-----------------VNCTT---- 407
            .|:|                     .|:|..:..|::.|                 :|..|
Worm  1359 RLITRFAQLANTTAPFFLGGFSLGHVNQRAQSQADIDTSKRGWLETIKDIAQSMRIINLNTTGIE 1423

  Fly   408 ------------------------------------------------------ALLTEE--ITS 416
                                                                  |||.:|  ...
Worm  1424 PATPKVLDPFAQNITLNQVVNDLLQNLDVRENVKVWFNNKIWPGFPIASNILSNALLRQEDYAID 1488

  Fly   417 PE-------RYPTS------------QFHQFWVVLKRTLL-------------FSYRD------- 442
            ||       .:|.:            :|.|...|.:.|:|             :...|
Worm  1489 PEDLGILTMNHPMNKTISQTLDQNALKFTQALAVFRITILLLVLSMIPAGFTVYLVEDRICEALH 1553

  Fly   443 ------------WTLMYL-RLFAHLLVGFLIGALYY-----DIGNDGAKVLSNLGFLFFNMLFLM 489
                        |...|| .:..:.||..:|..:|.     |...|||.      |..|.:||.:
Worm  1554 LQLVGGLRKVTYWVTSYLYDMVVYTLVIIVIMLIYLCFRVSDFTADGAT------FFAFLLLFFV 1612

  Fly   490 YTSMTITILSFPLEMPVLLKENFNRWYSLKSYYL--AISVADLPFQAIFCVIYVSIVYYFTSQPW 552
            :...||                      |.:|..  |.|||.|.|      :.::|..||..
Worm  1613 HGMSTI----------------------LYAYVFQKAFSVAALSF------VLIAIGSYFVG--- 1646

  Fly   553 ELFRFSMFLSACLLISFVAQSVGLVVGAAMNVQNGVFLA-PVMSVPFLLFSGFFV---------- 606
                ....|:..:|.|.:.|...|:  .|..|.:.|||. |..::...:|.|..:
Worm  1647 ----IVCALTVIMLESLMVQDPSLI--PAHTVCSIVFLVLPQYNLGIAIFRGLMIYQVRAIGSNF 1705

  Fly   607 -------------------SFDAIPVYLRWITYLSYIRYGFEGTALAT----------YGYGREK 642
                               :||.:.:::..:         |....:||          :|:.|::
Worm  1706 LQQMNRPDMINQLPLPSLLAFDQMGIHIMCL---------FIHVIIATICLIFSQMDEFGFVRKR 1761

  Fly   643 LRCFQTYCHFKSPITTLEELDMVNANFTLDIV--------ALIV 678
            .|........:.| :|.::.|:|.....:|.:        ||||
Worm  1762 ERNLTDAMMLREP-STCDDEDVVKERQRVDAIPMDSSDNHALIV 1804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3164	NP_722605.1	ABCG_EPDR	44..268	CDD:213180	72/252 (29%)
		3a01204	60..699	CDD:273361	179/933 (19%)
		ABC2_membrane	431..630	CDD:279410	48/268 (18%)
abt-2	NP_490949.3	rim_protein	39..2117	CDD:130324	185/954 (19%)
		ABC_subfamily_A	929..1134	CDD:213230	62/210 (30%)
		ABC_subfamily_A	1802..2024	CDD:213230	3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000