Protein Alignment CG4822 and ABCG1

DIOPT Version :9

• Sequence 1: NP_001033861.1
• Gene: CG4822 / 33170
• FlyBaseID: FBgn0031220
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: XP_024307909.1
• Gene: ABCG1 / 9619
• HGNCID: 73
• Length: 786
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 240/602 - (39%)
• Similarity: 356/602 - (59%)
• Gaps: 47/602 - (7%)

  Fly    73 KTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLAGFGAVCESGEILVNNSPRDMRVFRKMSRYI 137
            ||:|:.::|.|:|.||.||:|||||||:||:|:|||:......|.:|:|..|||:|.|||:|.||
Human   206 KTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYI 270

  Fly   138 MQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTLNTMAQKLSGGERKRL 202
            ||.|:|....||.|.|:::|:|||.::  .:.:.|::.|||..|.|....||....||||:||||
Human   271 MQDDMLLPHLTVQEAMMVSAHLKLQEK--DEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRL 333

  Fly   203 CIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEMLDAVYVL 267
            .|||||||||||:|.||||:|||..|..|.::|:|.||.|||::||:||.||||:||:.|.:|||
Human   334 AIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 398

  Fly   268 AEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADFIIEVACLEYGGSYHEPMVEAVGNGKVAR--- 329
            ::|||||:||..|:||:|::.||.||..:|||||::|||..|| |..:..:|.||..|....
Human   399 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEY-GDQNSRLVRAVREGMCDSDHK 462

  Fly   330 -------------WSPPAVEGETTT----TKTDTTS--GASSFYERDQFDEEISPKLLEAKCSWW 375
                         |..|:.|.:.|.    .:.|::|  |..||               .|.|  .
Human   463 RDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSF---------------SASC--L 510

  Fly   376 LQYKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMGTSASKALFNFGFMFTIVIAYLY 440
            .|:.:|..|..:.:.||.....|:...:|.:.||:|.||.|:|..|.|.|.|.||:|..::..::
Human   511 TQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMF 575

  Fly   441 LPMMPVLLYFPTEINLLKREYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIVYLMSSQPLEWF 505
            ..:||.:|.||.|:.:..||:.|.||.|.:||.|...:.:|...:..|.|.||||.|:|||.:..
Human   576 AALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAV 640

  Fly   506 RFAMLFTIAFVTALTSDSFGLLI-SSRLSLVNAMFMGPVLAVPLILLSIYGIGYGGGTYISPLMR 569
            ||.:...:..:|:|.:.|.|||| ::..||..|.|:|||.|:|::|.|.:.:.:   ..|...::
Human   641 RFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSF---DTIPTYLQ 702

  Fly   570 FLMHLSYLRHSMEGLVASLYDYGRADTICEDTEIFCSFKKSKVLLAFLGFENMHYLWSLSCLMSF 634
            ::.::||:|:..||::.|:|...|.|..| |.:..|.|:||:.:|..|..||.........|..|
Human   703 WMSYISYVRYGFEGVILSIYGLDREDLHC-DIDETCHFQKSEAILRELDVENAKLYLDFIVLGIF 766

  Fly   635 YLLFTVAAYFMIRLRLK 651
            ::...:.|||::|.:::
Human   767 FISLRLIAYFVLRYKIR 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	111/202 (55%)
		3a01204	67..654	CDD:273361	240/602 (40%)
		ABC2_membrane	381..587	CDD:279410	72/206 (35%)
ABCG1	XP_024307909.1	3a01204	202..786	CDD:273361	240/602 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2712
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.760