DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and PDR18

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_014468.3	Gene:	PDR18 / 855807	SGDID:	S000005353	Length:	1333	Species:	Saccharomyces cerevisiae

Alignment Length:	716	Identity:	184/716 - (25%)
Similarity:	306/716 - (42%)	Gaps:	159/716 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VKGSTTSQI----SSLQYSSDINA-----DSLEPDQSEDFQTVLGLKYLPS-----WPAVNLQFS 57
            ||..|.:.|    ||.....::||     |..|...|.|..|....:.|.|     |..|:
Yeast   675 VKKGTKNAIQRSWSSKNDEENLNASIATQDMKEIASSNDDSTSADFEGLESTGVFIWKNVS---- 735

  Fly    58 ELCYVVPDQTNASKTKTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLAGFGAVCESGEILVNN 122
               :.:|   ::|..:.:|..|:|......|||:||.||||||||||.||.......:|::||:.
Yeast   736 ---FTIP---HSSGQRKLLDSVSGYCVPGTLTALIGESGAGKTTLLNTLAQRNVGTITGDMLVDG 794

  Fly   123 SPRDMRVFRKMSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTL 187
            .|.|.. |::.:.|:.|.|:..::.||.|.:..:|.::..:.:...:|:|.:::|:.:|.:::..
Yeast   795 LPMDAS-FKRRTGYVQQQDLHVAELTVKESLQFSARMRRPQSIPDAEKMEYVEKIISILEMQEFS 858

  Fly   188 NTMAQKLSGG----ERKRLCIALELVNNPP-VIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVI 247
            ..:..::..|    :||:|.|.:|||..|. ::||||||:|||..|:...:.:||.||..|::::
Yeast   859 EALVGEIGYGLNVEQRKKLSIGVELVGKPDLLLFLDEPTSGLDSQSAWAVVKMLKRLALAGQSIL 923

  Fly   248 CSIHTPSAKIFEMLDAVYVLAE-GQCVYQGK-GSN----IVPFLKNFGLCCPITYNPADFIIEVA 306
            |:||.|||.:||..|.:.:|.: ||.:|.|: |.|    |..|.||....|....|||::|:
Yeast   924 CTIHQPSATLFEQFDRLLLLGKGGQTIYFGEIGKNSSSVIKYFEKNGARKCQQNENPAEYIL--- 985

  Fly   307 CLEYGGSYHEPMVEAVGNGKVAR--------WSP------------PAVEGETTTTKTDTTSGAS 351
                         ||:|.|..|.        |..            ..::..::||...|.:.||
Yeast   986 -------------EAIGAGATASVQQNWPDIWQKSHEYANINEKINDMIKDLSSTTLHKTATRAS 1037

  Fly   352 SFYERDQFDEEISPKLLEAKCSWWLQYKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFG 416
            .:                 ..|:..|:..:|.|..:..||:.:||..|..:.::..|.:|..:|.
Yeast  1038 KY-----------------ATSYSYQFHHVLKRSSLTFWRNLNYIMAKMMLLMISGLFIGFTFFH 1085

  Fly   417 MGTSA---SKALFNFGFMFTIVIAYLYLPMMPVLLYFPTEINLLK-----REYNNQWYRLSSYYA 473
            :|.:|   ..:||.. ||..::.|       |..........:.|     ||..:..:..|....
Yeast  1086 VGVNAIGLQNSLFAC-FMAIVISA-------PATNQIQERATVAKELYEVRESKSNMFHWSLLLI 1142

  Fly   474 AMVTSKLPSMFILAVIY-------LSIVYLMSSQPLEWFRFAMLFTIAFV-TALTSDSFGLLISS 530
            ....::||...:.:.|:       |.:....|...:.:..:|:||.:.:: .||..    |.:|.
Yeast  1143 THYLNELPYHLLFSTIFFVSSYFPLGVFTEASRSSVFYLNYAILFQLYYIGLALMI----LYMSP 1203

  Fly   531 RLSLVNAMFMGPVLAVPLILLSIYG------IGYGGGTY---ISP-------LMRFLMHLSYLRH 579
            .|...| :.:|.:|:   .|||..|      :..|..|:   :||       |:..|||...:|.
Yeast  1204 NLQSAN-VIVGFILS---FLLSFCGAVQPASLMPGFWTFMWKLSPYTYFLQNLVGLLMHDKPVRC 1264

  Fly   580 SMEGLVASLYDYGRADTICEDTEIF-------------------CSFKKSKVLLAFLGFENMHYL 625
            |.:.|  ||::.....|..|.|:.|                   |.:|.....||.:. .:..||
Yeast  1265 SKKEL--SLFNPPVGQTCGEFTKPFFEFGTGYIANPDATADCAYCQYKVGDEYLARIN-ASFSYL 1326

  Fly   626 W 626
            |
Yeast  1327 W 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	77/230 (33%)
		3a01204	67..654	CDD:273361	166/642 (26%)
		ABC2_membrane	381..587	CDD:279410	53/237 (22%)
PDR18	NP_014468.3	3a01205	1..1333	CDD:273362	184/716 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341524
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2712
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	1	0.900	-	-		OOG6_100151
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	7	6.690