DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and PDR5

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_014796.3	Gene:	PDR5 / 854324	SGDID:	S000005679	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	720	Identity:	188/720 - (26%)
Similarity:	316/720 - (43%)	Gaps:	132/720 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SDINAD-SLEPDQSEDFQTVLGLKYLPSWPAVNLQFSELCYVVPDQTNASKTKTILRRVNGMFHS 85
            ||:::| .:..:.||:.....|...|....|: ..:..|||.|  |..| :|:.||..|:|....
Yeast   837 SDLSSDRKMLQESSEEESDTYGEIGLSKSEAI-FHWRNLCYEV--QIKA-ETRRILNNVDGWVKP 897

  Fly    86 HELTAIIGPSGAGKTTLLNLLA---GFGAVCESGEILVNNSPRDMRVFRKMSRYIMQTDVLDSQF 147
            ..|||::|.|||||||||:.||   ..|.:  :|:||||..||| :.|.:...|..|.|:.....
Yeast   898 GTLTALMGASGAGKTTLLDCLAERVTMGVI--TGDILVNGIPRD-KSFPRSIGYCQQQDLHLKTA 959

  Fly   148 TVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKD----TLNTMAQKLSGGERKRLCIALEL 208
            ||.|.:..:|.|:...|:::::|...::|::.:|.::.    .:....:.|:..:||||.|.:||
Yeast   960 TVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEMEKYADAVVGVAGEGLNVEQRKRLTIGVEL 1024

  Fly   209 VNNPP-VIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEMLD-AVYVLAEGQ 271
            ...|. ::||||||:|||..::.....|:|.||..|:.::|:||.|||.:.:..| .:::...|:
Yeast  1025 TAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQRGGK 1089

  Fly   272 CVY---QGKG-SNIVPFLKNFGL-CCPITYNPADFIIEVACLEYGGSYHEPMVEAVGNGKVARWS 331
            .||   .|:| ..::.:.::.|. .||...|||::::||.....|...::...|...|.:..|
Yeast  1090 TVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQDYYEVWRNSEEYR-- 1152

  Fly   332 PPAVEGETTTTKTDTTSGASSFYERDQFDEEISPKLLEAKCSWWLQYKLLLVRMLIQMWRDKSYI 396
              ||:.|....:.:.....|.....|:  .|.|..::       .|.||:.:|:..|.||...|:
Yeast  1153 --AVQSELDWMERELPKKGSITAAEDK--HEFSQSII-------YQTKLVSIRLFQQYWRSPDYL 1206

  Fly   397 KLKFYMNIVLALLVGSLYFGMGTSASKALFN---FGFMFTIV---IAYLYLPMMPVLLYFPTEIN 455
            ..||.:.|...|.:|..:|..|||. :.|.|   ..||||::   |...|||.      |..:.:
Yeast  1207 WSKFILTIFNQLFIGFTFFKAGTSL-QGLQNQMLAVFMFTVIFNPILQQYLPS------FVQQRD 1264

  Fly   456 LLK-REYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIVYLMSSQPLEWFRFA----------- 508
            |.: ||..::.:...|:..|.:..::|...:..    :|.|.:...|:.::..|
Yeast  1265 LYEARERPSRTFSWISFIFAQIFVEVPWNILAG----TIAYFIYYYPIGFYSNASAAGQLHERGA 1325

  Fly   509 --MLFTIAFVTALTSDSFGLLI-------SSRLSLVNAMFMGPVLAVPLILLSIYGIGYGGGTYI 564
              .||:.||...:  .|.|||:       .|..:|.:.:|        .:.||..|:    .|..
Yeast  1326 LFWLFSCAFYVYV--GSMGLLVISFNQVAESAANLASLLF--------TMSLSFCGV----MTTP 1376

  Fly   565 SPLMR---FLMHLSYLRHSMEGLVASLYDYGRADTICEDTEIF---------------------- 604
            |.:.|   |:..:|.|.:.::.|:|  ......|..|.|.|:.
Yeast  1377 SAMPRFWIFMYRVSPLTYFIQALLA--VGVANVDVKCADYELLEFTPPSGMTCGQYMEPYLQLAK 1439

  Fly   605 ------------CSFKKSKVLLAFLGFENMHY--LWS----LSCLMSFYLLFTVAAYFMIRLRLK 651
                        |||.:......:|...|..|  .|.    ..|.::|..:..|..|::.|:..|
Yeast  1440 TGYLTDENATDTCSFCQISTTNDYLANVNSFYSERWRNYGIFICYIAFNYIAGVFFYWLARVPKK 1504

  Fly   652 HSEVS 656
            :.::|
Yeast  1505 NGKLS 1509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	82/236 (35%)
		3a01204	67..654	CDD:273361	174/670 (26%)
		ABC2_membrane	381..587	CDD:279410	56/235 (24%)
PDR5	NP_014796.3	ABC_trans_N	46..152	CDD:405234
PDR5	NP_014796.3	3a01205	100..1503	CDD:273362	186/712 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341527
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	1	0.900	-	-		OOG6_100151
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	6	5.740