DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and AUS1

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_014654.1	Gene:	AUS1 / 854175	SGDID:	S000005537	Length:	1394	Species:	Saccharomyces cerevisiae

Alignment Length:	783	Identity:	180/783 - (22%)
Similarity:	310/783 - (39%)	Gaps:	235/783 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 STTSQISSLQYS-SDINADSLEPDQSED--FQTVLGLKYLPSWPAVNLQFSELCYVVPDQTNASK 71
            |::|.:|::.|. |..|.:....|.:|.  .:||...|::.||..:|       |.|       .
Yeast   711 SSSSSLSAVPYQISPSNKEMALNDYNEQPITETVETQKHIISWKNIN-------YTV-------G 761

  Fly    72 TKTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLA---GFGAVCESGEILVNNSP-RDMRVFRK 132
            ||.::...:| |.|..|||::|.||||||||||:|:   ..|.|  |||||::..| .|...|::
Yeast   762 TKKLINNASG-FISSGLTALMGESGAGKTTLLNVLSQRVETGVV--SGEILIDGHPLTDEDAFKR 823

  Fly   133 MSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEV------------IDEILGMLRLKD 185
            ...::.|.|:               :|.|   |::|:.||:            :|.:..:|:|..
Yeast   824 SIGFVQQQDL---------------HLDL---LSVKESLEISCLLRGDGDRAYLDTVSNLLKLPS 870

  Fly   186 TLNTMAQKLSGGERKRLCIALELVNNPP-VIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICS 249
            .:  :...|:..:||.|.|.:|||..|. ::||||||:|||..::...:..||.|:..|:.:.|:
Yeast   871 DI--LVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSGLDAEAALTIVKFLKQLSLQGQAIFCT 933

  Fly   250 IHTPSAKIFEMLDAVYVLAE-GQCVYQG----------KGSNIVPFLKNFGLCCPITYNPADFII 303
            ||.||..:....|.:::|.. |:||:.|          ...|.:.:.|...       |||||:|
Yeast   934 IHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMSHDNTLVYDKEHD-------NPADFVI 991

  Fly   304 EVACLEYGGSYHEPMVEAVGNGKVARWSPPAVEGETTTTKT-DTTSGASSFYERDQFDEEISPKL 367
                            :||||...:.....|.|..|...:. |.::...|..|:....:|.:...
Yeast   992 ----------------DAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVKKETARLE 1040

  Fly   368 LEAKCS--------W----WLQYKLLLV-RMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMGT 419
            .:|:.|        |    :||...|:. |..|...||.:|:..|:.:|....|.:|
Yeast  1041 DDARASGVDYTTSLWKQPSYLQQLALITRRQYICTKRDMTYVMAKYCLNGGAGLFIG-------- 1097

  Fly   420 SASKALFNF--------GFMFTIVIAYLYLPM-MPVLLYFPTEINLLKREYNNQWYRLSSYY--- 472
                  |:|        |...:|...::.|.: .|::.....:....|..|..:..|.::|:
Yeast  1098 ------FSFWHIKHNIIGLQDSIFFCFMALCVSSPLINQIQDKALKTKEVYVAREARSNTYHWTV 1156

  Fly   473 -----------AAMVTSKLPSMFILA--------------VIYLSIVYLMSSQPLEWFRFAMLFT 512
                       .|:.:|.|  .|:.|              |.:|:  |::.:.........:::|
Yeast  1157 LLLSQSIIELPLALTSSTL--FFVCAFFSCGFNNAGWSAGVFFLN--YMLFAAYYSTLGLWLIYT 1217

  Fly   513 ----------IAFVTALTSDSFGLLISSRLSLVNAMFMGPVLAVPLILLSIYGIG---YGGGTYI 564
                      :||:.:.|:...|:             |.|....|.....:|.:.   |...|::
Yeast  1218 APNLQTAAVFVAFIYSFTASFCGV-------------MQPYSLFPTFWKFMYRVSPYTYFVETFV 1269

  Fly   565 SPLMRFLMHLSYLRHSMEGLV---------------ASLYDYG------RADTICEDTEIFCSFK 608
            |    .|:|...::..|..:|               |.:.:||      ...|:|    .:|::.
Yeast  1270 S----ILLHNWEIKCDMSEMVPGQPLTGQSCGQFMEAFIEEYGGYLHNKNTFTVC----AYCTYT 1326

  Fly   609 KSKVLLAFLGFENMHY--LWSLSCL------MSFYLLFTVAAYFMIRLRLKHSEVSPIFAYVIQL 665
            ...   .||..|||.|  :|....:      .:|:.:|  |.|::       :.|:.|:..|.::
Yeast  1327 VGD---DFLKNENMSYDHVWRNFGIEWAFVGFNFFAMF--AGYYL-------TYVARIWPKVFKI 1379

  Fly   666 LTK 668
            :||
Yeast  1380 ITK 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	76/242 (31%)
		3a01204	67..654	CDD:273361	159/707 (22%)
		ABC2_membrane	381..587	CDD:279410	44/271 (16%)
AUS1	NP_014654.1	3a01205	56..1369	CDD:273362	175/768 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341534
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	1	0.900	-	-		OOG6_100151
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	5	4.830