DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and PDR15

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_010694.1	Gene:	PDR15 / 852015	SGDID:	S000002814	Length:	1529	Species:	Saccharomyces cerevisiae

Alignment Length:	736	Identity:	186/736 - (25%)
Similarity:	310/736 - (42%)	Gaps:	138/736 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VKGSTTSQISSLQYSSDINADSLEPDQSEDFQTVLGLKYLPSWPAVNLQFSELCYVVPDQTNASK 71
            ::.:..|...|......|..||.|...|......|||    |.......:.:|||.||.:   ..
Yeast   841 IENNAGSSPDSATTEKKILDDSSEGSDSSSDNAGLGL----SKSEAIFHWRDLCYDVPIK---GG 898

  Fly    72 TKTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLA---GFGAVCESGEILVNNSPRDMRVFRKM 133
            .:.||..|:|......|||::|.|||||||||:.||   ..|.:  :|.|.|:...|| ..|.:.
Yeast   899 QRRILNNVDGWVKPGTLTALMGASGAGKTTLLDCLAERVTMGVI--TGNIFVDGRLRD-ESFPRS 960

  Fly   134 SRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKD----TLNTMAQKL 194
            ..|..|.|:.....||.|.:..:|.|:....:::::|...::|::.:|.::.    .:....:.|
Yeast   961 IGYCQQQDLHLKTATVRESLRFSAYLRQPSSVSIEEKNRYVEEVIKILEMQQYSDAVVGVAGEGL 1025

  Fly   195 SGGERKRLCIALELVNNPP-VIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIF 258
            :..:||||.|.:||...|. ::||||||:|||..::.....|::.||..|:.::|:||.|||.:.
Yeast  1026 NVEQRKRLTIGVELAARPKLLVFLDEPTSGLDSQTAWDTCQLMRKLATHGQAILCTIHQPSAILM 1090

  Fly   259 EMLDAVYVLAE-GQCVY---QGKG-SNIVPFLKNFGL-CCPITYNPADFIIEVACLEYGGSYHEP 317
            :..|.:..|.: ||.||   .|:| ..::.:.::.|. .||...|||::::||.....|....:.
Yeast  1091 QQFDRLLFLQKGGQTVYFGDLGEGCKTMIDYFESKGAHKCPPDANPAEWMLEVVGAAPGSHATQD 1155

  Fly   318 MVEAVGNGKVARWSPPAVEGETTTTKTDTTSGASSFYERDQFDEEISPKLLEAK---CSWWLQYK 379
            ..|...|....:    ||:.|.            .:.|::.......|...|.|   .|.:.|:|
Yeast  1156 YNEVWRNSDEYK----AVQEEL------------DWMEKNLPGRSKEPTAEEHKPFAASLYYQFK 1204

  Fly   380 LLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMGTSASKALFNFG------FMFTIV--- 435
            ::.:|:..|.||...|:..||.:.|...:.:|..:|    .|.::|....      ||:|::
Yeast  1205 MVTIRLFQQYWRSPDYLWSKFILTIFNQVFIGFTFF----KADRSLQGLQNQMLSIFMYTVIFNP 1265

  Fly   436 IAYLYLPMMPVLLYFPTEINLLK-REYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIVY---- 495
            |...|||.      |..:.:|.: ||..::.:...:::.:.:..::|...:...|...|.|
Yeast  1266 ILQQYLPS------FVQQRDLYEARERPSRTFSWLAFFLSQIIVEIPWNILAGTIAYCIYYYAVG 1324

  Fly   496 ----------LMSSQPLEWFRFAMLFTIAFVTALTSDSFGLL-ISSRLSLVNAMFMGPVLAVPLI 549
                      |.....|.|     ||:|||...:  .|.||| ||.......|..||.:|..  :
Yeast  1325 FYANASAAGQLHERGALFW-----LFSIAFYVYI--GSMGLLMISFNEVAETAAHMGTLLFT--M 1380

  Fly   550 LLSIYGIGYGGGTYISPLMR-----FLMHLSYLRHSMEGLVA----------SLYDYGR----AD 595
            .||..|:      ..:|.:.     |:..:|.|.:.::.|:|          |.|:..:    :.
Yeast  1381 ALSFCGV------MATPKVMPRFWIFMYRVSPLTYMIDALLALGVANVDVKCSNYEMVKFTPPSG 1439

  Fly   596 TICED-------------------TEIFCSFKKSKVLLAFLGFENMHYL--WS----LSCLMSFY 635
            |.|.|                   |:| |||.......|||...:.||.  |.    ..|.::|.
Yeast  1440 TTCGDYMASYIKLAGTGYLSDPSATDI-CSFCAVSTTNAFLATFSSHYYRRWRNYGIFICYIAFD 1503

  Fly   636 LLFTVAAYFMIRLRLKHSEVS 656
            .:.....|::.|:..|:.::|
Yeast  1504 YIAATFLYWLSRVPKKNGKIS 1524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	76/236 (32%)
		3a01204	67..654	CDD:273361	169/672 (25%)
		ABC2_membrane	381..587	CDD:279410	54/245 (22%)
PDR15	NP_010694.1	ABC_trans_N	47..162	CDD:405234
PDR15	NP_010694.1	3a01205	110..1518	CDD:273362	184/728 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341525
Domainoid	1	1.000	102	1.000	Domainoid score	I1517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm13430
orthoMCL	1	0.900	-	-		OOG6_100151
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	6	5.740