DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and PEN3

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_176196.1	Gene:	PEN3 / 842281	AraportID:	AT1G59870	Length:	1469	Species:	Arabidopsis thaliana

Alignment Length:	633	Identity:	174/633 - (27%)
Similarity:	275/633 - (43%)	Gaps:	164/633 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 LPSWPAVNLQFSELCYVVP------DQTNASKTKTILRRVNGMFHSHELTAIIGPSGAGKTTLLN 104
            ||..| :.:.|.::.|.|.      ||........:|:.|.|.|....|||::|.||||||||::
plant   860 LPFTP-LAMSFDDVKYFVDMPGEMRDQGVTETRLQLLKGVTGAFRPGVLTALMGVSGAGKTTLMD 923

  Fly   105 LLAG--FGAVCESGEILVNNSPRDMRVFRKMSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNL 167
            :|||  .|...| |::.::..|:....|.::|.|..|||:...|.||.|.:|.:|.|:|.||:..
plant   924 VLAGRKTGGYIE-GDVRISGFPKVQETFARISGYCEQTDIHSPQVTVRESLIFSAFLRLPKEVGK 987

  Fly   168 KQKLEVIDEILGMLRLKDTLNTMAQKLSG------GERKRLCIALELVNNPPVIFLDEPTTGLDD 226
            .:|:..:|:::.::.| |:|......|.|      .:||||.||:|||.||.:||:||||:|||.
plant   988 DEKMMFVDQVMELVEL-DSLRDSIVGLPGVTGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDA 1051

  Fly   227 LSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEMLDAVYVLAE-GQCVYQGK-GSN---IVPFLK 286
            .:::..:..::.....||||:|:||.||..|||..|.:.::.. ||.:|.|. |.|   :|.:.:
plant  1052 RAAAIVMRAVRNTVDTGRTVVCTIHQPSIDIFEAFDELMLMKRGGQVIYAGPLGQNSHKVVEYFE 1116

  Fly   287 NF-GLC-CPITYNPADFIIEVACL--------EYGGSYHEPMVEAVGNGKVARWS-PPAVEGETT 340
            :| |:. .|..||||.:::|.:.|        ::...|::..:.......|...| |||
plant  1117 SFPGVSKIPEKYNPATWMLEASSLAAELKLSVDFAELYNQSALHQRNKALVKELSVPPA------ 1175

  Fly   341 TTKTDTTSGASSFYERDQFDEEISPKLLEAKCSWWLQYKLLLVRMLIQMWRDKSYIKLKFYMNIV 405
                    |||..|...||.:           :.|.|:|..|.:.....||...|..::|...:.
plant  1176 --------GASDLYFATQFSQ-----------NTWGQFKSCLWKQWWTYWRSPDYNLVRFIFTLA 1221

  Fly   406 LALLVGSLYFGMGTSASKALFNFGFMFTIVIAYLYL--------------PMMPVLLYFPTEINL 456
            .:||:|::::.:|.:.|    |.|.: |:||..||.              ||:.|      |..:
plant  1222 TSLLIGTVFWQIGGNRS----NAGDL-TMVIGALYAAIIFVGINNCSTVQPMVAV------ERTV 1275

  Fly   457 LKREYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIVYLM-----SSQPLEWFRFAMLFTIAFV 516
            ..||.....|....|..:.||.:||.:.|..|.|..|||.|     .::...||.|...|:..:.
plant  1276 FYRERAAGMYSAMPYAISQVTCELPYVLIQTVYYSLIVYAMVGFEWKAEKFFWFVFVSYFSFLYW 1340

  Fly   517 T-------ALTSDS--------------------------------------------FGLLIS- 529
            |       :||.:.                                            :||::|
plant  1341 TYYGMMTVSLTPNQQVASIFASAFYGIFNLFSGFFIPRPKIPKWWIWYYWICPVAWTVYGLIVSQ 1405

  Fly   530 -----SRLSLVNAM------------------FMGPVLAVPLILLSIY 554
                 :|:.::...                  |||||.|| ||..:::
plant  1406 YGDVETRIQVLGGAPDLTVKQYIEDHYGFQSDFMGPVAAV-LIAFTVF 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	87/239 (36%)
		3a01204	67..654	CDD:273361	166/606 (27%)
		ABC2_membrane	381..587	CDD:279410	56/268 (21%)
PEN3	NP_176196.1	PLN03140	31..1469	CDD:215599	174/633 (27%)
		ABC_trans_N	89..165	CDD:291196
		ABCG_PDR_domain1	154..426	CDD:213200
		ABC2_membrane	527..733	CDD:279410
		PDR_assoc	740..800	CDD:285559
		ABCG_PDR_domain2	864..1102	CDD:213199	88/240 (37%)
		ABC2_membrane	1197..1404	CDD:279410	45/217 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100151
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810