DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and ABCG6

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_196862.1	Gene:	ABCG6 / 831202	AraportID:	AT5G13580	Length:	727	Species:	Arabidopsis thaliana

Alignment Length:	756	Identity:	178/756 - (23%)
Similarity:	311/756 - (41%)	Gaps:	179/756 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSVKGSTTSQISSLQYSSD----------INADSLEPDQSEDFQTVLGLKYLPSWPAVNLQFSEL 59
            |....|.|:....||...|          ::.|...||||..|.               |.|::|
plant    24 SGASSSPTTFAQLLQNVDDSTRRSHHQHHVDVDLASPDQSVPFV---------------LSFTDL 73

  Fly    60 CYVVPDQTN-------------------ASKTKTILRRVNGMFHSHELTAIIGPSGAGKTTLLNL 105
            .|.|..:..                   :|||||:|..:.|.....|:.|::|.||:||:||::.
plant    74 TYSVKVRRKFTWRRSVSSDPGAPSEGIFSSKTKTLLNGITGEARDGEILAVLGASGSGKSTLIDA 138

  Fly   106 LAG-------FGAVCESGEILVNNSPRDMRVFRKMSRYIMQTDVLDSQFTVLEMMILAANLKLGK 163
            ||.       .|.|..:||:|  ||    ::.:.:|.|:||.|:|....||.|.::.||..:|.:
plant   139 LANRIAKGSLKGNVTLNGEVL--NS----KMQKAISAYVMQDDLLFPMLTVEETLMFAAEFRLPR 197

  Fly   164 ELNLKQKLEVIDEILGMLRLKDTLNTMA-----QKLSGGERKRLCIALELVNNPPVIFLDEPTTG 223
            .|:..:|...:..::..|.|::..||:.     :.:|||||:|:.|.::::::|.::||||||:|
plant   198 SLSKSKKSLRVQALIDQLGLRNAANTVIGDEGHRGISGGERRRVSIGIDIIHDPILLFLDEPTSG 262

  Fly   224 LDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEMLDAVYVLAEGQCVYQGKGSNIVPFLKNF 288
            ||..|:...|.:||.:|..|..||.::|.||.::..:||.:..|:.||.|:.|..:.:..|...|
plant   263 LDSTSALSVIKVLKRIAQSGSMVIMTLHQPSYRLLRLLDRLLFLSRGQTVFSGSPAMLPRFFAEF 327

  Fly   289 GLCCPITYNPADFIIEV------------ACLEY---------------GGSYHEPMVEAVGNGK 326
            |...|...|..:|.:::            :.:|:               |.|..|.:..::..||
plant   328 GHPIPEHENRTEFALDLIRELEGSAGGTRSLVEFNKGFRQRKAEPRSQTGLSLKEAISASISKGK 392

  Fly   327 VARWSPPAVEGETTTTKTDTTSGASSFYERDQFDEEISPKLLEAKCSWWLQYKLLLVRMLIQMWR 391
            :       |.|.||||.:..:|..|:.           |....   .:|::..:|..|.:....|
plant   393 L-------VSGATTTTHSSGSSPVSTI-----------PTFAN---PFWVELAVLAKRSMTNSRR 436

  Fly   392 DKSYIKLKFYMNIVLALLVGSLYFGMGTS---ASKALFNFGFMFTIVIAYLYLPMMPVLLYFPTE 453
            ......::....:|...::.::::.:..|   ..:.|..|.|..:... |.....:||.|   .|
plant   437 QPELFGIRLGAVLVTGFILATMFWQLDNSPKGVQERLGCFAFAMSTTF-YTCADALPVFL---QE 497

  Fly   454 INLLKREYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIVYLMSSQPLEW--------FRFAML 510
            ..:..||.....||.|||..:.....|||:.||::.:.:|.:        |        ..|...
plant   498 RFIFMRETAYNAYRRSSYVLSHSLVALPSLIILSLAFAAITF--------WGVGLDGGLMGFLFY 554

  Fly   511 FTIAFVTALTSDSFGLLISSRLSLVNAMFMGPVLAVPLILLSIYGIGYGG---------GTYISP 566
            |.:...:.....||...:|   .:|..:.:|..:.|.::   .|.:.:.|         |.:|
plant   555 FLVILASFWAGSSFVTFLS---GVVPHVMLGYTIVVAIL---AYFLLFSGFFINRDRIPGYWI-- 611

  Fly   567 LMRFLMHLSYLRHSMEGLVASLYDYG-------RADTICEDTEIFCSFKKSKV-LLAFLGFENMH 623
               :..::|.:::..|.::  |.::|       |...|.::|.:....:..|| |||.:......
plant   612 ---WFHYISLVKYPYEAVL--LNEFGDPTKCFVRGVQIFDNTPLVAVPQGMKVRLLATMSKSLGM 671

  Fly   624 YLWSLSCLMSFY----------------LLFTVAAYFMIRL 648
            .:.|.:||.:.|                |..|||..|..|:
plant   672 RITSSTCLTTGYDILQQQGVTDLTKWNCLWVTVAWGFFFRI 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	82/255 (32%)
		3a01204	67..654	CDD:273361	161/684 (24%)
		ABC2_membrane	381..587	CDD:279410	41/225 (18%)
ABCG6	NP_196862.1	3a01204	105..726	CDD:273361	159/660 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	121	1.000	Domainoid score	I1855
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920