DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and Abcg8

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_080456.1	Gene:	Abcg8 / 67470	MGIID:	1914720	Length:	673	Species:	Mus musculus

Alignment Length:	679	Identity:	168/679 - (24%)
Similarity:	291/679 - (42%)	Gaps:	126/679 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 STTSQISSLQYSSDINADSLEPDQSEDFQTVLGLKYLPSWPAVNLQFSELC-YVVPDQTNASKTK 73
            |.|.::..|.|..||.:.                  :| |      |.:|. :.:|.::::|:..
Mouse    45 SNTLEVRDLTYQVDIASQ------------------VP-W------FEQLAQFKIPWRSHSSQDS 84

  Fly    74 TIL--RRVNGMFHSHELTAIIGPSGAGKTTLLNLLA--GFGAVCESGEILVNNSPRDMRVFRKMS 134
            ..|  |.::....|.::.||||.||.|:.:||:::.  |.|...:||:|.:|..|...::.||..
Mouse    85 CELGIRNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKMKSGQIWINGQPSTPQLVRKCV 149

  Fly   135 RYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTL-----NTMAQKL 194
            .::.|.|.|....||.|.:...|.::|.:..:..|:.:.:::::..|||:...     ||..:.:
Mouse   150 AHVRQHDQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGV 214

  Fly   195 SGGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFE 259
            |||||:|:.|.::|:.||.::.|||||:|||..::...:..|..||.|.|.|:.|:|.|.:.||.
Mouse   215 SGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVTTLSRLAKGNRLVLISLHQPRSDIFR 279

  Fly   260 MLDAVYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADFII------------EVACLEYGG 312
            :.|.|.::..|..:|.|....:|.:..:.|..||...|||||.:            |||.:|...
Mouse   280 LFDLVLLMTSGTPIYLGAAQQMVQYFTSIGHPCPRYSNPADFYVDLTSIDRRSKEREVATVEKAQ 344

  Fly   313 SYHEPMVEAVGNGKVARWSPPAVEGETTT-----TKT-DTTSGASSFYERDQFDEEISPKLLEAK 371
            |.....:|.|.......|...|.|..|:|     |.| ||..|.:         .|: |.::|
Mouse   345 SLAALFLEKVQGFDDFLWKAEAKELNTSTHTVSLTLTQDTDCGTA---------VEL-PGMIE-- 397

  Fly   372 CSWWLQYKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMGTSASKALFNFGFMFTIVI 436
                 |:..|:.|.:...:||...:.:......:::|::|.||:|.|..      ...||.|..:
Mouse   398 -----QFSTLIRRQISNDFRDLPTLLIHGSEACLMSLIIGFLYYGHGAK------QLSFMDTAAL 451

  Fly   437 AYLYLPMMP------VLLYFPTEINLLKREYNNQWYRLSSYYAAMVTSKLPSMFILAVIY-LSIV 494
            .::...::|      |:....:|.::|..|..:..|....|:.|.:..:||......:|| :.|.
Mouse   452 LFMIGALIPFNVILDVVSKCHSERSMLYYELEDGLYTAGPYFFAKILGELPEHCAYVIIYAMPIY 516

  Fly   495 YLMSSQPLEWFRFAMLFTIAFVTALTSDSFGLLISSRL-----------SLVNAMFMGPVLAVPL 548
            :|.:.:|:... |.:.|.:.::......:..|..|:.|           :|.|:.::.....:.|
Mouse   517 WLTNLRPVPEL-FLLHFLLVWLVVFCCRTMALAASAMLPTFHMSSFFCNALYNSFYLTAGFMINL 580

  Fly   549 ILLSIYGIGYGGGTYISPLMRFLMHLSYLRHSMEGLVASLYDYGRADT---------ICEDTEIF 604
                       ...:|.|  .::..||:||....||:...:: |...|         |..||.|.
Mouse   581 -----------DNLWIVP--AWISKLSFLRWCFSGLMQIQFN-GHLYTTQIGNFTFSILGDTMIS 631

  Fly   605 CSFKKSKVLLAF--------LGFENMHYL 625
            .....|..|.|.        .||..::||
Mouse   632 AMDLNSHPLYAIYLIVIGISYGFLFLYYL 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	72/234 (31%)
		3a01204	67..654	CDD:273361	157/621 (25%)
		ABC2_membrane	381..587	CDD:279410	44/223 (20%)
Abcg8	NP_080456.1	ABCG_White	71..296	CDD:213201	70/224 (31%)
		3a01204	89..664	CDD:273361	155/610 (25%)
		ABC2_membrane	402..606	CDD:279410	44/223 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831357
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53689
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.760