Protein Alignment CG4822 and ABCG5

DIOPT Version :10

• Sequence 1: NP_608493.2
• Gene: CG4822 / 33170
• FlyBaseID: FBgn0031220
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_071881.1
• Gene: ABCG5 / 64240
• HGNCID: 13886
• Length: 651
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 145/571 - (25%)
• Similarity: 255/571 - (44%)
• Gaps: 68/571 - (11%)

  Fly    72 TKTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLAG-FG-AVCESGEILVNNSPRDMRVFRKMS 134
            |:.||:.|:....|.::..|:|.||:||||||:.::| .| |....||:.||........|:...
Human    65 TRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCF 129

  Fly   135 RYIMQTDVLDSQFTVLEMMILAANLKL--GKELNLKQKLEVIDEILGMLRLKDTL--NTMAQKLS 195
            .|::|:|.|.|..||.|.:...|.|.:  |...:.::|:|.:...|.:..:.|.|  |.....:|
Human   130 SYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSLGGIS 194

  Fly   196 GGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEM 260
            .|||:|:.||.:|:.:|.|:..||||||||.::::|.:.||..||...|.|:.:||.|.:::|::
Human   195 TGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQL 259

  Fly   261 LDAVYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADFIIEVACLEYGGSYHE-------PM 318
            .|.:.:|:.|:.::.|..:.::.|..:.|..||...||.||.:::..::......|       .|
Human   260 FDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQM 324

  Fly   319 VEAVGNGKVARWSPPAVEGETTTT----KTDTTSGASSFYERDQFDEEISPKLLEAKCSWWLQYK 379
            :|:.       :...|:..:|...    |...|.....|..:|      ||.:..       :..
Human   325 IESA-------YKKSAICHKTLKNIERMKHLKTLPMVPFKTKD------SPGVFS-------KLG 369

  Fly   380 LLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMGTSASKALF--NFGFMFTIVIAYLYLP 442
            :||.|:...:.|:|..:..:...|:::.|.:......:.::..|...  ..|.::..|.|..|..
Human   370 VLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTG 434

  Fly   443 MMPVLLYFPTEINLLKREYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIVYLMSSQPLEWFRF 507
            |:..:..||....:..:|..:..|:......|.....||...:..:|:.|:.|.......|..||
Human   435 MLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARF 499

  Fly   508 AMLFTIAFVTALTSDSFGLLISSRLSLV------NAMFMGPVLAVPLILLSIYGIGYGGGTYIS- 565
            ..     |..||.:..   ||...|:||      |...:..|:|    ||||.|:..|.|...:
Human   500 GY-----FSAALLAPH---LIGEFLTLVLLGIVQNPNIVNSVVA----LLSIAGVLVGSGFLRNI 552

  Fly   566 ---PL-MRFLMHLSYLRHSMEGLVASLYDYG-----RADTICEDTEIFCSF 607
               |: .:.:.:.::.::..|.||.:.: ||     .:..:...|...|:|
Human   553 QEMPIPFKIISYFTFQKYCSEILVVNEF-YGLNFTCGSSNVSVTTNPMCAF 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_608493.2	3a01204	67..654	CDD:273361	145/571 (25%)
ABCG5	NP_071881.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		ABCG_White	50..275	CDD:213201	72/209 (34%)
		3a01204	60..645	CDD:273361	145/571 (25%)