Protein Alignment CG4822 and ABCG4

DIOPT Version :9

• Sequence 1: NP_001033861.1
• Gene: CG4822 / 33170
• FlyBaseID: FBgn0031220
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_001135977.1
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 251/631 - (39%)
• Similarity: 362/631 - (57%)
• Gaps: 63/631 - (9%)

  Fly    45 YLPSWPAVNLQFSELCYVVPDQTNASKT--KTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLA 107
            :||...||:::|.||.|.|.:.....|.  ||:|:.::|.|...||..|:|||||||:|.:|:||
Human    52 HLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILA 116

  Fly   108 GFGAVCESGEILVNNSPRDMRVFRKMSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLE 172
            |:......|:||||..||::|.|||||.||||.|:|....||||.|:::|||||.::..:|:  |
Human   117 GYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKK--E 179

  Fly   173 VIDEILGMLRLKDTLNTMAQKLSGGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLK 237
            ::.|||..|.|....:|....||||:||||.|||||||||||:|.||||:|||..|..|.::|:|
Human   180 LVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 244

  Fly   238 VLAAGGRTVICSIHTPSAKIFEMLDAVYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADFI 302
            .||.||||:||:||.||||:|||.|.:|:|::|||:::|..:|::|:||..||.||..:||||||
Human   245 SLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFI 309

  Fly   303 IEVACLEYGGSYHEPMV-EAVGNGKVA----RWSP-----PA-----------VEGETTTTKTDT 346
            ||||..|||..  .||: .||.||..|    :.||     ||           :|..|..|.|.|
Human   310 IEVASGEYGDL--NPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLT 372

  Fly   347 TSGASSFYERDQFDEEISPKLLEAKCSWWLQYKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVG 411
                                          |:.:|..|..:.:.||.....|:|..::|:.:|:|
Human   373 ------------------------------QFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIG 407

  Fly   412 SLYFGMGTSASKALFNFGFMFTIVIAYLYLPMMPVLLYFPTEINLLKREYNNQWYRLSSYYAAMV 476
            .||..:|..|||...|.|.:|..::..::..:||.:|.||.|:.:..||:.|.||.|.:||.|..
Human   408 LLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKT 472

  Fly   477 TSKLPSMFILAVIYLSIVYLMSSQPLEWFRFAMLFTIAFVTALTSDSFGLLI-SSRLSLVNAMFM 540
            .:.:|...:..|:|.||||.|:.||.|..||.:...:|..|||.:.|.|||| ::..||..|.|:
Human   473 MADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFV 537

  Fly   541 GPVLAVPLILLSIYGIGYGGGTYISPLMRFLMHLSYLRHSMEGLVASLYDYGRADTICEDTEIFC 605
            |||.|:|::|.|.:.:.:   ..|...:::..:|||:|:..||::.::|...|.|..|  .|..|
Human   538 GPVTAIPVLLFSGFFVSF---KTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTC--LEERC 597

  Fly   606 SFKKSKVLLAFLGFENMHYLWSLSCLMSFYLLFTVAAYFMIRLRLK 651
            .|::.:.:|..|..|:.........|..|:|...:.||.::|.|:|
Human   598 PFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVK 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	119/226 (53%)
		3a01204	67..654	CDD:273361	242/609 (40%)
		ABC2_membrane	381..587	CDD:279410	73/206 (35%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	251/631 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177791at33208
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850