DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and abca3b

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_009297489.1	Gene:	abca3b / 564344	ZFINID:	ZDB-GENE-050517-2	Length:	1703	Species:	Danio rerio

Alignment Length:	878	Identity:	183/878 - (20%)
Similarity:	299/878 - (34%)	Gaps:	314/878 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPDQSEDFQTVLGLKYLPSWPA---VNLQFSELCYVVPDQTNASKTKTILRRVNGMFHSHELTAI 91
            |.:..||.:.....:::...||   ..::...|..|.   ...:|:|..:|.:.......::|.:
Zfish   501 EKEDEEDAEKASKGEFMEEEPAGLVAGVKIKRLAKVF---KVGNKSKEAVRDLTLNMFEGQITVL 562

  Fly    92 IGPSGAGKTTLLNLLAGFGAVCESGEILVNNSP--RDMRVFRKMSRYIMQTDVLDSQFTVLEMMI 154
            :|.:||||||.|::|.|.... .||...:|...  :||.:.|:......|.|||....||.|.::
Zfish   563 LGHNGAGKTTTLSMLTGLFPP-SSGRAYINGYDICQDMALIRRSLGLCPQHDVLFDNLTVREHLL 626

  Fly   155 LAANLKLGKELNLKQKLE-VIDEILGMLRLKDTLNTMAQKLSGGERKRLCIALELVNNPPVIFLD 218
            ....|| |..   ::|:. .:|.|:.:|.|:|..|...:.||||.:::|.|.:.|:.:..|:.||
Zfish   627 FYTQLK-GYP---REKIPGEVDRIIRILNLEDKRNAKCKTLSGGMKRKLSIGIALIGDSKVVMLD 687

  Fly   219 EPTTGLDDLSSSQCIALLKVLAAG---GRTVICSIHTPSAKIFEML-DAVYVLAEG--QCVYQGK 277
            |||:|:|..:......||:    |   |||::.:.|.....  ::| |.:.::|.|  ||.
Zfish   688 EPTSGMDPSARRATWDLLQ----GEKRGRTILLTTHFMDEA--DLLGDRIAIMASGELQCC---- 742

  Fly   278 GSNIVPFLKNFGLCCPITYNPADFIIEVACLEYGGSYHEPMV-EAVGN-GKVAR----WSPPAVE 336
            ||.:  ||||                     :||..||..:| :|..| .::.|    :.|.|.
Zfish   743 GSPL--FLKN---------------------KYGAGYHMVIVKDAFCNVSEITRLVHMYVPDAT- 783

  Fly   337 GETTTTKTDTTSGASSFY-------------------ERDQFD-----------EEI---SPKLL 368
                   .::::||...|                   .||:..           ||:   ..||:
Zfish   784 -------LESSAGAELSYILPKESTSRFELLFAELEMNRDELGIASYGASVTTMEEVFLRVGKLV 841

  Fly   369 EAKC-------------------SWWLQYKLLLVRM---------LIQMWRDKSYIKL----KFY 401
            ::..                   .|.:.....:..|         ...:..|.|.|||    :.|
Zfish   842 DSSLDIQAIQLPALQYQHERRSHDWTMDDSSSISGMTDVTDFTDSCTMISEDGSNIKLNTGARLY 906

  Fly   402 MNIVLAL-LVGSLYFGMGTSASKALFNFGFMFTIVIAYLYLPMMPVLLYFPTEINLLKREYNNQW 465
            |....|: |..:||.........|.|....:|| |:|.:....:|.....| ::.|..::|....
Zfish   907 MQQFYAMFLKRALYSWRNWKVMVAQFLVPLIFT-VLALVVARSLPSSHSSP-QLRLALKQYGQTH 969

  Fly   466 Y---------RLSSYYAAMVTSKLPSMFILAVIYLS-----IVY------------------LMS 498
            .         .|:|..|.:.|::|||...:|...::     ::|                  ..|
Zfish   970 VPVAVEANAGPLASLLAEIYTTQLPSQNAIAAPNITDFSEYVLYNAQREGGAFNEHCVVGAAFRS 1034

  Fly   499 SQPLEWFR------------------------------------------------------FAM 509
            |..:.:|.                                                      ||:
Zfish  1035 SDVIGYFNNQGYHTPATALMLVDNALFKLLAGPNASIQTGNDPMPRNVSETAQSQLSESQTGFAI 1099

  Fly   510 LFTIAFVTALTSDSFGLLISSRLS-------------------------LVNAMFMGPVLAV--- 546
            ...:.:..|..:.:|.||:.|..|                         |:|  |:.|.|.:
Zfish  1100 AINLMYGMASLASTFALLLVSERSVKSKHVQQVSGVYLTNFWFSALLWDLIN--FLLPCLLMLVV 1162

  Fly   547 -----------------PLILLSIYGIGYGGGTYISPLMRFLMHL------SYLRHSMEGLVASL 588
                             .|.||.:||..      :.|||..:..|      :|.|.::..:::
Zfish  1163 FRVFSVKAFVAQNHLVDVLFLLLLYGWA------VIPLMYLMSFLFSTAATAYTRLTIFNIIS-- 1219

  Fly   589 YDYGRAD-------TICEDTEIFCSFKKSKVLLAFLGFENMHYLWSLSCL-MSFYLLFTVAAYFM 645
               |.|.       ||.|...:..|....||.|.|..:          || |||...:  ..|.|
Zfish  1220 ---GTATFLAVTIMTIPELNLLHLSHLLDKVFLIFPNY----------CLGMSFTEFY--QNYEM 1269

  Fly   646 IRLRLKHSEVSPIFAYVIQLLTKYFNFT-SYNY 677
            |..    ...||:..|:    .||:|.| ..||
Zfish  1270 ITF----CTSSPLAKYI----CKYYNITYQMNY 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	68/236 (29%)
		3a01204	67..654	CDD:273361	167/812 (21%)
		ABC2_membrane	381..587	CDD:279410	58/356 (16%)
abca3b	XP_009297489.1	AAA	1..>95	CDD:333001
abca3b	XP_009297489.1	AAA	<122..1695	CDD:333001	183/878 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000