DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and w

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_476787.1	Gene:	w / 31271	FlyBaseID:	FBgn0003996	Length:	687	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	172/613 - (28%)
Similarity:	300/613 - (48%)	Gaps:	66/613 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLA-----GFGAVCESGEILVNNSPRDMRVFRK 132
            |.:|:.|.|:.:..||.|::|.||||||||||.||     |. .|..||..|:|..|.|.:..:.
  Fly   110 KHLLKNVCGVAYPGELLAVMGSSGAGKTTLLNALAFRSPQGI-QVSPSGMRLLNGQPVDAKEMQA 173

  Fly   133 MSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTLNTM------A 191
            ...|:.|.|:.....|..|.:|..|.:::.:.|..:|::..:|:::..|.|....:|:      .
  Fly   174 RCAYVQQDDLFIGSLTAREHLIFQAMVRMPRHLTYRQRVARVDQVIQELSLSKCQHTIIGVPGRV 238

  Fly   192 QKLSGGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAK 256
            :.|||||||||..|.|.:.:||::..||||:|||..::...:.:||.|:..|:|||.:||.||::
  Fly   239 KGLSGGERKRLAFASEALTDPPLLICDEPTSGLDSFTAHSVVQVLKKLSQKGKTVILTIHQPSSE 303

  Fly   257 IFEMLDAVYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADFIIEVACLEYGGSYHEPMVEA 321
            :||:.|.:.::|||:..:.|..|..|.|....|..||..||||||.::|.              |
  Fly   304 LFELFDKILLMAEGRVAFLGTPSEAVDFFSYVGAQCPTNYNPADFYVQVL--------------A 354

  Fly   322 VGNGKVARWSPPAVEGETTTTKTDTTSGASSFYERDQFDEEISPKLLEA-----------KCSWW 375
            |..|:       .:|......|. ..:.|.|...|| .::.::.|.||.           |.:|:
  Fly   355 VVPGR-------EIESRDRIAKI-CDNFAISKVARD-MEQLLATKNLEKPLEQPENGYTYKATWF 410

  Fly   376 LQYKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMGTSASKALFNFGFMFTIVIAYLY 440
            :|::.:|.|..:.:.::...:|::.....::|:|:|.::.|...:....:...|.:|..:....:
  Fly   411 MQFRAVLWRSWLSVLKEPLLVKVRLIQTTMVAILIGLIFLGQQLTQVGVMNINGAIFLFLTNMTF 475

  Fly   441 LPMMPVLLYFPTEINLLKREYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIVYLM---SSQPL 502
            ..:...:..|.:|:.:..||..::.||..:|:.....::||....:.:::.:|.|.|   .:..|
  Fly   476 QNVFATINVFTSELPVFMREARSRLYRCDTYFLGKTIAELPLFLTVPLVFTAIAYPMIGLRAGVL 540

  Fly   503 EWFRFAMLFTIAFVTALTSDSFGLLISSRLSLVN-AMFMGPVLAVPLILLSIYGIGYGGGTYISP 566
            .:|....|.|:   .|..|.|||.|||...|..: |:.:||.:.:|.:|...:.:..|.   :..
  Fly   541 HFFNCLALVTL---VANVSTSFGYLISCASSSTSMALSVGPPVIIPFLLFGGFFLNSGS---VPV 599

  Fly   567 LMRFLMHLSYLRHSMEGLVASLY-DYGRADTICEDTEIFCSFKKSKVLLAFLGFE----NMHYLW 626
            .:::|.:||:.|::.|||:.:.: |....:..|..:...|. ...||:|..|.|.    .:.|:.
  Fly   600 YLKWLSYLSWFRYANEGLLINQWADVEPGEISCTSSNTTCP-SSGKVILETLNFSAADLPLDYVG 663

  Fly   627 SLSCLMSFYLLFTVAAYFMIRLRLKHSE 654
            ....::||.:|    ||..:|||.:..|
  Fly   664 LAILIVSFRVL----AYLALRLRARRKE 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	78/213 (37%)
		3a01204	67..654	CDD:273361	171/611 (28%)
		ABC2_membrane	381..587	CDD:279410	47/209 (22%)
w	NP_476787.1	3a01204	68..687	CDD:273361	171/611 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	1	1.000	-	-		mtm14984
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
	8	7.850