DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4822 and Abca4

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001101191.1	Gene:	Abca4 / 310836	RGDID:	1309445	Length:	2290	Species:	Rattus norvegicus

Alignment Length:	421	Identity:	108/421 - (25%)
Similarity:	177/421 - (42%)	Gaps:	88/421 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KGSTTSQISSLQYSSDINADSLEPDQSED--FQTVL-GLKYLPSWPAVNLQFSELCYVVPDQTNA 69
            :|.:|.:..:|:.:..:..:..:|:..||  |:..| ||  :|.....||.          :...
  Rat   865 EGCSTREERALEKTEPLTEEIEDPEYPEDSFFERELPGL--VPGVCVKNLV----------KVFE 917

  Fly    70 SKTKTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLAGFGAVCESGEILVNNSPRDMRV----F 130
            ..::..:.|:|..|:.:::||.:|.:||||||.|::|.|. ....||.:|:..  :|:.:    .
  Rat   918 PGSRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGL-LPPTSGTVLIGG--KDIEISLDAV 979

  Fly   131 RKMSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTLNTMAQKLS 195
            |:......|.::|....||.|.::..|.||.......:.::|.:.|..|   |....|..||.||
  Rat   980 RQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEARLEMEAMLEDTG---LHHKRNEEAQDLS 1041

  Fly   196 GGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEM 260
            ||.:::|.:|:..|.:..|:.|||||:|:|..|......|| :....|||:|.|.|.....  ::
  Rat  1042 GGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLL-LKYRSGRTIIMSTHHMDEA--DL 1103

  Fly   261 L-DAVYVLAEGQ------------CVYQGKGSNIVPFLKNF--------GLC----------CPI 294
            | |.:.::::|:            |...|....:|..:||.        |.|          ||.
  Rat  1104 LGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRCGCEGACSCTSKGFSARCPA 1168

  Fly   295 TYNPADFIIEVACLE----------YGGSYHEP---MVEAVG--------NGKVARWSPPAVEGE 338
            .   .|.|.|...|:          |   :|.|   :||.:|        |....:.:..::..|
  Rat  1169 R---VDEITEEQVLDGDVKELTDLVY---HHVPEAKLVECIGQELIFLLPNKNFKQRAYASLFRE 1227

  Fly   339 TTTTKTDTTSGASSFYERDQFDEEISPKLLE 369
            ...|..|.  |.|||...|...|||..|:.|
  Rat  1228 LEETLADL--GLSSFGISDTPLEEIFLKVTE 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	65/241 (27%)
		3a01204	67..654	CDD:273361	95/359 (26%)
		ABC2_membrane	381..587	CDD:279410
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	108/421 (26%)
		ABC_subfamily_A	907..1126	CDD:213230	64/237 (27%)
		ABC_subfamily_A	1915..2135	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000