DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and Abca12

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_237242.6	Gene:	Abca12 / 301482	RGDID:	1304586	Length:	2595	Species:	Rattus norvegicus

Alignment Length:	674	Identity:	146/674 - (21%)
Similarity:	240/674 - (35%)	Gaps:	235/674 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LQYSSDINADSLEPD---------QSEDFQTVLGLKYLPSWPAVNLQFSELCYVVPDQTNASKTK 73
            :..|::.:|:...||         :.:|.|..:.|..:                    |.:..:|
  Rat  1314 MMQSTNPSANKTSPDCAFPSNIEPEPKDLQVGVALHGV--------------------TKSYGSK 1358

  Fly    74 TILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLAG-FGAVCESGEILV--NNSPRDMRVFRKMSR 135
            |.:..:|..|:...:|:::||:||||||.:::|.| |||.  :|.|.|  .:...|:...||...
  Rat  1359 TAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAT--AGTIFVYGKDIKTDLNTVRKNMG 1421

  Fly   136 YIMQTDVLDSQFTVLEMMILAANLKL----GKELNLKQKLEVIDEILGMLRLKDT-LNTMAQK-- 193
            ..||.|||.|..|..|.::|..::|:    .|:|:.:.|          ..|||| |.:...|
  Rat  1422 VCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVK----------RTLKDTGLYSHRHKRV 1476

  Fly   194 --LSGGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAG--GRTVICSIHTPS 254
              ||||.:::|.|::.|:....|:.||||:||:|..|..   ::..|::..  .||:|.|.|
  Rat  1477 GTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRR---SIWDVISKNKTARTIILSTH--- 1535

  Fly   255 AKIFEMLDAVYVLAEGQCVYQGKGSNIVPFLKNFGL-CCPITYNPADFIIEVACLEYGGSYHEPM 318
                 .||...||           |:.:.||:..|| ||     .:.|.::.|   :|..||..:
  Rat  1536 -----HLDEAEVL-----------SDRIAFLEQGGLRCC-----GSPFYLKEA---FGDGYHLTL 1576

  Fly   319 VEAVGNGKVARWSPPAVEGETTTTKTDTTSGASSFYERDQFDEEISPKLL------EAKCSWWLQ 377
            .:.         ..|.::..........|:...|........|:|..:|:      ..|.|.  .
  Rat  1577 TKK---------KSPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSG--A 1630

  Fly   378 YKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGM------------------------- 417
            | |.|:|.|     ||...||......:....|..::..:
  Rat  1631 Y-LSLLRAL-----DKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKCGNMSLEHLTQRKVGNPSA 1689

  Fly   418 -GTSA---------------------SKALFNFGFMFTIVIAYLYLPMMPVLLYFPTEINLLKRE 460
             |||.                     |:.|..||.:...::|.                 |:||.
  Rat  1690 NGTSTPDDLSVSSSNFTDRDDKVLTRSERLDGFGLLLKKIMAI-----------------LIKRF 1737

  Fly   461 YNNQ--WYRLSSYYAAMVTSKLPSMFILAVIYLSIVYLMSSQPLEWFRFAMLFTIAFVTALTSDS 523
            ::.:  |..|                 :|.:.|.||::.::..|...|.            :|:|
  Rat  1738 HHTRRNWKGL-----------------IAQVVLPIVFVATAMGLGTLRD------------SSNS 1773

  Fly   524 FGLLISSRLSLVNAMFMGPVLAVPLILLSIYGIGYGGGTYISPLMRFLMHLSYLRHSMEGLVASL 588
            :                 |.|   ||..||||.......|.:           ...|...||::|
  Rat  1774 Y-----------------PEL---LISPSIYGNSEQTAFYAN-----------FDPSTNALVSAL 1807

  Fly   589 YDYGRADTICEDTEIFCSFKKSKV 612
            :::...|.:|.:|......||..:
  Rat  1808 WNFPGIDNVCLNTSDSQCLKKDNL 1831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	70/238 (29%)
		3a01204	67..654	CDD:273361	139/616 (23%)
		ABC2_membrane	381..587	CDD:279410	41/254 (16%)
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	80/285 (28%)
		ABC_subfamily_A	1350..1565	CDD:213230	78/273 (29%)
		ABC2_membrane_3	<1913..2174	CDD:289468
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000