DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and Abcg3

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_017176394.1	Gene:	Abcg3 / 27405	MGIID:	1351624	Length:	683	Species:	Mus musculus

Alignment Length:	671	Identity:	154/671 - (22%)
Similarity:	287/671 - (42%)	Gaps:	153/671 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EPDQ--SEDFQTVLGL--KYLPSWPAVN------------LQFSELCYVVPDQTN--ASKTKTIL 76
            ||.:  |.:..||:.:  ::|...|..|            |.|..:.|....|:.  ..|...::
Mouse    70 EPPEMASNNDPTVISMIERHLCDLPETNTSDLKTLTEEAVLSFHNISYQETVQSGFPLRKKAYVI 134

  Fly    77 RRVNGM--FHSHELTAIIGPSGAGKTTLLNLLA------GFGAVCESGEILVNNSPRDMRVFRKM 133
            .|::.:  .....|.||:||....::.||::||      |.     ||:||:|..||... |:..
Mouse   135 ERLSNISGIMKPGLNAIMGPQDGSRSLLLDVLAARRDPRGL-----SGDILINGKPRPAN-FKCT 193

  Fly   134 SRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTLNTMAQKLSGGE 198
            |.|:.|.||:....||.:.:..:|.|:|...:...:|...|:|:|.:|.|....|...:  |...
Mouse   194 SGYVPQNDVVLGTVTVRDNLEFSAALRLPVTITRDEKRRRINEVLELLHLNKEQNIKPR--SKEL 256

  Fly   199 RKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEMLDA 263
            |||..||:|||...|::|||:||||||..:::..|.:|:.::..|||:|.||:.|...||:..|:
Mouse   257 RKRTSIAMELVTEHPILFLDDPTTGLDLRTTTDVILVLRRMSKKGRTIIFSINQPQYSIFKFFDS 321

  Fly   264 VYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADFIIEVACLEYGGSYHEPMVEAVGNGKVA 328
            :.::|.|:.::.|...:.:.:.::.|.......|||||.::|.                 ||
Mouse   322 LTLVASGKVMFHGPAQDALEYFRSAGYNYESHNNPADFFLDVI-----------------NG--- 366

  Fly   329 RWSPPAVEGETTTTKTDTTSGASSFYERDQFDE------EISPKL--LEAKCSWWLQYKLLLVRM 385
                    |.:....|:...     :|.|:::|      :::.||  :.|:...:.:.:.:|.::
Mouse   367 --------GFSNILDTEEDG-----HEDDKYEELFERQYQVTGKLANMYAQSPLYSETRAILDQL 418

  Fly   386 LIQMWRDKS----------------YIKLKFYMN---------------IVLALLVGSLYFGMGT 419
            |.:...::|                :|..:.:.|               ::||..||:.:..:..
Mouse   419 LGEQKLERSSAVETTCVTPFCHQLKWIICQSFKNFKGFPWVTVIQAIITVILATAVGTAFRVLKN 483

  Fly   420 SASKALFNFGFMFTIVIAYLYLPMMPVLLYFPTEINLLKREYNNQWYRLSSYYAAMVTSKL-PSM 483
            ...:.....|.::.:.|......:....|:....:..| .|:.:.:||:|||:...:.::| |..
Mouse   484 DCIEVQMRAGLLYLLTIFQCITSVSAGELFVIDRVRFL-HEHTSGYYRVSSYFFGKLLAELIPRR 547

  Fly   484 FILAVIYLSIVYLMS--SQPLEWFRFAMLFTIAFVTALTSDSFGLLISSRLSLVNAMFMGPVLAV 546
            .:.:.::..|.|:::  ...::.| |.|:.|| .|.|.::.|..|.|.:..:.|         ||
Mouse   548 LLPSTVFSLITYVIAGVKMSMKCF-FTMICTI-MVLAYSASSLPLSIGAGENAV---------AV 601

  Fly   547 PLILLSIY--------GIGYGGGTYISPL------------MRFLMHLSYL------RHSMEGLV 585
            |.:|::||        |:....|:::..|            .|.|:|..:|      .|:.|. |
Mouse   602 PTLLVTIYFVFMLFFSGLSLYSGSFLPKLSWIQYFSIPHYGFRALLHNEFLGQNFCPEHNTEE-V 665

  Fly   586 ASLYDYGRADTICEDTEIFCS 606
            :..::|..:..:|     .||
Mouse   666 SRCHNYVMSRILC-----ICS 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	75/246 (30%)
		3a01204	67..654	CDD:273361	142/618 (23%)
		ABC2_membrane	381..587	CDD:279410	50/265 (19%)
Abcg3	XP_017176394.1	3a01204	137..670	CDD:273361	136/586 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900