DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4822 and Abcg2

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001342406.1	Gene:	Abcg2 / 26357	MGIID:	1347061	Length:	657	Species:	Mus musculus

Alignment Length:	665	Identity:	187/665 - (28%)
Similarity:	313/665 - (47%)	Gaps:	109/665 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LQFSELCYVVPDQTN--ASKT--KTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLA------G 108
            |.|..:.|.|..::.  ..||  |.||..:||:. ...|.||:||:|.||::||::||      |
Mouse    37 LSFHHITYRVKVKSGFLVRKTVEKEILSDINGIM-KPGLNAILGPTGGGKSSLLDVLAARKDPKG 100

  Fly   109 FGAVCESGEILVNNSPRDMRVFRKMSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEV 173
            .     ||::|:|.:|:... |:..|.|::|.||:....||.|.:..:|.|:|...:...:|.|.
Mouse   101 L-----SGDVLINGAPQPAH-FKCCSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMKNHEKNER 159

  Fly   174 IDEI---LGMLRLKDTL--NTMAQKLSGGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCI 233
            |:.|   ||:.::.|:.  ....:.:|||||||..|.:||:.:|.::||||||||||..:::..:
Mouse   160 INTIIKELGLEKVADSKVGTQFIRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVL 224

  Fly   234 ALLKVLAAGGRTVICSIHTPSAKIFEMLDAVYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNP 298
            .|||.::..|||:|.|||.|...||::.|::.:||.|:.|:.|.....:.:..:.|..|....||
Mouse   225 LLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLVFHGPAQKALEYFASAGYHCEPYNNP 289

  Fly   299 ADFIIEVACLEYGGSYHEPMV-------EAVGNGKVARWSPPAVE------------GETTTTKT 344
            |||.::|    ..|.....|:       ||....:.::...|.:|            || |..:.
Mouse   290 ADFFLDV----INGDSSAVMLNREEQDNEANKTEEPSKGEKPVIENLSEFYINSAIYGE-TKAEL 349

  Fly   345 DTTSGASSFYERDQFDEEISPKLLEAKCSW--WL---QYKLLL------VRMLIQMWRDKSYIKL 398
            |...||........|.|   |..:.:.|..  |:   .:|.||      |..||
Mouse   350 DQLPGAQEKKGTSAFKE---PVYVTSFCHQLRWIARRSFKNLLGNPQASVAQLI----------- 400

  Fly   399 KFYMNIVLALLVGSLYFGMGTSASKALFNFGFMFTIVIAYLYLPMMPVLLYFPTEINLLKREYNN 463
               :.::|.|::|::||.:...|:......|.:|.:.....:..:..|.| |..|..|...||.:
Mouse   401 ---VTVILGLIIGAIYFDLKYDAAGMQNRAGVLFFLTTNQCFSSVSAVEL-FVVEKKLFIHEYIS 461

  Fly   464 QWYRLSSYYAAMVTSK-LPSMFILAVIYLSIVYLM--SSQPLEWFRFAMLFTIAFVTALTSDSFG 525
            .:||:|||:...|.|. ||..|:.:||:..|:|.|  ..:.::.| |.|:||:..| |.|:.|..
Mouse   462 GYYRVSSYFFGKVMSDLLPMRFLPSVIFTCILYFMLGLKKTVDAF-FIMMFTLIMV-AYTASSMA 524

  Fly   526 LLISSRLSLVNAMFMGPVLAVPLILLSIY-GIGYGGGTYISPLMRFLMHLSYLRHSMEGLVASLY 589
            |.|::..|:|:...:  ::.:..:.:.:: |:.....| |.|.:.:|.:.|..|:   |..|..|
Mouse   525 LAIATGQSVVSVATL--LMTIAFVFMMLFSGLLVNLRT-IGPWLSWLQYFSIPRY---GFTALQY 583

  Fly   590 D--YGRA---------DTICEDTEIFCSFKKSKVLLAFLGFENMHY-LW----SLSCLMSFYLLF 638
            :  .|:.         ::.|.::...|:   ....|...|.|...: ||    :|:|::   ::|
Mouse   584 NEFLGQEFCPGFNVTDNSTCVNSYAICT---GNEYLINQGIELSPWGLWKNHVALACMI---IIF 642

  Fly   639 TVAAYFMIRLRLKHS 653
            ...||..:....|:|
Mouse   643 LTIAYLKLLFLKKYS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	87/236 (37%)
		3a01204	67..654	CDD:273361	183/652 (28%)
		ABC2_membrane	381..587	CDD:279410	56/215 (26%)
Abcg2	NP_001342406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
Abcg2	NP_001342406.1	3a01204	46..651	CDD:273361	182/648 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831360
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750