DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and pdr1

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_593995.1	Gene:	pdr1 / 2543363	PomBaseID:	SPAPB24D3.09c	Length:	1396	Species:	Schizosaccharomyces pombe

Alignment Length:	723	Identity:	166/723 - (22%)
Similarity:	302/723 - (41%)	Gaps:	139/723 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KGSTTSQISS--LQYSSDINADSLEPDQSE-DFQTVLGLKYLPSWPAVNLQFSELCYVVPDQTNA 69
            |..:.||::|  |....|......|||..: |..|.|...       .||   .||:...:.|..
pombe   714 KRKSYSQVASSFLIEPQDKPPSQTEPDNKKVDVSTTLSTN-------DNL---VLCWRDLNFTVV 768

  Fly    70 SKT--KTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLAGFG-AVCESGEILVN--NSPRDMRV 129
            :||  |.||..|:|....:.|||::|.:.:||:.||.:|:..| |....|||.::  .:|:::
pombe   769 TKTSKKQILTNVSGYLKKNTLTALLGENKSGKSVLLRILSQRGIAGSVEGEITLSGLKNPKNL-- 831

  Fly   130 FRKMSRYIMQTDVLDSQFTVLEMMILAANLKLGKELNLKQK---LEVIDEILGMLRLKD-TLNTM 190
             ||...|:.:..:..|::||.|.:.|.|.|:..|:.:|.::   :|.:.:.||:..:.| .:..|
pombe   832 -RKRIGYVRKNPLFISEYTVRETLRLHAALRQSKQRSLSEQYAYVEYVIDFLGLGEVADFIVGDM 895

  Fly   191 AQKLSGGERKRLCIALELVNNP-PVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPS 254
            .:.||...::.|.||:||...| .::.||||..|||..|:...:.:|:.||..|.:::||:..||
pombe   896 GKGLSLYHKRLLSIAVELSARPGSILLLDEPANGLDSQSAWMLVCILQKLARSGLSILCSVSQPS 960

  Fly   255 AKIFEMLDAVYVL-AEGQCVY---QGKG-SNIVPFLKNFGLCCPITYNPADFIIEVACLEYGGSY 314
            ::|.|:.|.:.:| ..|..||   .|:. |.:|.:.|........:.:.|||::.  |:::  ..
pombe   961 SRILELFDMMLILDLNGNTVYYDTMGRDLSKLVNYFKRIHGTNEHSKDTADFVLH--CIQF--LK 1021

  Fly   315 HEPMVEAVGNGKVARWSPPAVEGETTTTKTDTTSGASSFYERDQFDEEISPKLLEAKCSWWLQYK 379
            ..|..:..|     .|:       :|.|........:...:..:..::..|.......|::.|..
pombe  1022 QGPEFDYAG-----AWA-------STNTHKQIIEHVNFIMDNPELTDDDFPNETRFMTSFFFQIY 1074

  Fly   380 LLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYF--GMGTSASKALFNFGFMFTIVIAYLYLP 442
            .:.:|..:..|||.|.::.:...|||..|::|..::  |:|...::......:|.|:........
pombe  1075 KISMRNFVAYWRDSSLLRARVAFNIVAGLIIGFSFYKQGVGVEETQNKMFSAYMLTVASTSTMNG 1139

  Fly   443 MMPVLLYFPTEINLLKREYNNQWYRLSSYYA------------AMVTSKLPSMFILAVIYLSIVY 495
            :.|..:||        |....|:.:.::.|:            |::.....::|.....|.|..|
pombe  1140 LQPKFIYF--------RSIYEQYEQNTAIYSRTAFIIAFFLVEAVINCCFATLFFFGWYYPSGFY 1196

  Fly   496 LMSSQPLEWFRFA----MLFTIAFVT-----ALTSDSFGLL-ISSRLSLVNAMFMGPVLAVPLIL 550
            ..:.....:..||    |:||:.:.|     |..|.|.|.. |.|..:.|...:...::.:|.::
pombe  1197 EFNHNIPFYGGFAWLMLMIFTLYYTTLGIGIATISPSIGTASIISGTAFVFIQYFNGMIQLPGVI 1261

  Fly   551 LSIYGIGYGGGTYISPLMRFLMHLSYLRHSMEGLVAS-LYDYGRADTICEDTEI----------- 603
            :..:              :::..||..::.:||::.. |:|   |...||..||
pombe  1262 VGFW--------------KWMDALSPYKYFLEGMIGGVLHD---APITCEKFEIHYVDPPPNYSC 1309

  Fly   604 --------------------------FCSFKKSKVLLAFLGFENMHYLWSLSCLMSFYLLF---- 638
                                      :|.:|.:..|:...|:...| .|...|:|..|..|
pombe  1310 GEYFSSFLNSSGHGIVYNPEAYSSCQYCPYKNADELMVGFGYHYNH-KWRNFCIMIGYTAFNLGA 1373

  Fly   639 TVAAYFMI 646
            .:|.|::|
pombe  1374 AIALYYII 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	75/238 (32%)
		3a01204	67..654	CDD:273361	150/661 (23%)
		ABC2_membrane	381..587	CDD:279410	43/229 (19%)
pdr1	NP_593995.1	3a01205	40..1382	CDD:273362	166/723 (23%)
		ABCG_PDR_domain1	70..302	CDD:213200
		ABC2_membrane	421..620	CDD:279410
		PDR_CDR	634..>701	CDD:283960
		ABCG_PDR_domain2	755..983	CDD:213199	75/233 (32%)
		ABC2_membrane	1076..1284	CDD:279410	43/229 (19%)
		PDR_CDR	<1349..>1377	CDD:283960	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3039
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9277
orthoMCL	1	0.900	-	-		OOG6_100151
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
TreeFam	0	0.000	Not matched by this tool.
	4	3.900