DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4822 and abca1

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_004910916.1	Gene:	abca1 / 100491942	XenbaseID:	XB-GENE-1001143	Length:	2311	Species:	Xenopus tropicalis

Alignment Length:	326	Identity:	82/326 - (25%)
Similarity:	140/326 - (42%)	Gaps:	69/326 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VNGM---FHSHELTAIIGPSGAGKTTLLNLLAG-FGAVCESGEILVNNSPRDMRVFRKMSRYIMQ 139
            |:|:   |:..::|:.:|.:||||||.:::|.| |.....:..|:..:...::...|:......|
Frog   920 VDGLTLNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTTGTAYIMKKDIRTELNSIRQNLGVCPQ 984

  Fly   140 TDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTLNTMAQKLSGGERKRLCI 204
            .:||....||.|.:...|.||...|..:|.::|.:...:|:...|   .....:||||.:::|.:
Frog   985 HNVLFDALTVEEHIWFYARLKGLSEEKVKAEMEQMVNDVGLPHKK---KYKTSQLSGGMQRKLSV 1046

  Fly   205 ALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSI-HTPSAKIFEMLDAVYVLA 268
            ||..|....|:.|||||.|:|..|......|| :....|||:|.|. |...|.|  :.|.:.:::
Frog  1047 ALAFVGGSKVVILDEPTAGVDPYSRRGIWELL-IKYRQGRTIILSTHHMDEADI--LGDRIAIIS 1108

  Fly   269 EGQ--CVYQGKGSNIVPFLKN------------------FGLC----CPITYNPADFIIEVACLE 309
            .|:  ||    ||::  ||||                  ...|    ..::|...:...:.||.:
Frog  1109 HGKLCCV----GSSL--FLKNQLGTGYYLTLVKRDNDSSLSSCRNSSSTMSYLKKESSKQTACKQ 1167

  Fly   310 YGGSYHEPMVEA------------------VGNGKVARWSPPAVEGETTTTKTDTTSGASSFYER 356
                :..||:.|                  .|..|.|:      :.|.:.:::.:.:|..|.:|.
Frog  1168 ----HPSPMIAAPSASGTTAAVITKHSKHTAGQKKEAK------DREDSVSQSSSDAGLGSDHES 1222

  Fly   357 D 357
            |
Frog  1223 D 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	61/203 (30%)
		3a01204	67..654	CDD:273361	82/326 (25%)
		ABC2_membrane	381..587	CDD:279410
abca1	XP_004910916.1	rim_protein	1..2272	CDD:130324	82/326 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000