DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and abcg5

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_031757398.1	Gene:	abcg5 / 100145776	XenbaseID:	XB-GENE-963936	Length:	662	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	148/565 - (26%)
Similarity:	262/565 - (46%)	Gaps:	69/565 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LCYVVPD--------QTNASK-TKTILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLAG----FG 110
            :||.|.:        |:...| |:.||:.|:....|.::.||:|.||:||||||:.::|    .|
Frog    54 ICYTVSERIGPWWDIQSYYKKWTRQILKDVSFFLESGQIMAILGNSGSGKTTLLDAMSGRIGHKG 118

  Fly   111 AVCESGEILVNNSPRDMRVFRKMSRYIMQTDVLDSQFTVLEMMILAANLKLGKELN--LKQKLEV 173
            .:.  ||:.||.|......|:....|::|.|.|.|..||.|.:...|.|.|.|...  :|:|::.
Frog   119 TLL--GEVYVNGSQLKKEQFQNCFSYVLQHDTLLSYLTVRETLTYTALLALQKHSKQAIKEKVQS 181

  Fly   174 IDEILGMLRLKDTL--NTMAQKLSGGERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALL 236
            :...|.::::.:::  ..:...:|.|||:|:.||.:|:.:|.:|.|||||||||.::::|.:.||
Frog   182 VMTELSLMQVANSVIGGRIFNGISSGERRRVSIAAQLIQDPKIILLDEPTTGLDSMTANQIVLLL 246

  Fly   237 KVLAAGGRTVICSIHTPSAKIFEMLDAVYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADF 301
            ..||...|.||.|||.|.:::|.:.|.:.:::.|:.::.|....::.|....|..||...||.||
Frog   247 SELARKDRIVIISIHQPRSELFRVFDKIAIMSLGELIFCGNPDEMISFFDGCGYECPQHSNPFDF 311

  Fly   302 IIEVACLEYGGSYHEPMVEAVGNGKVARWSPPAVEGETTTTKTDTTSGA---SSFYE-------- 355
            .:::..::......|                  :|   |.:::...:.|   |.||:
Frog   312 YVDLTSVDTRSKERE------------------LE---TYSRSQAIASAYKNSDFYQNALEKIKT 355

  Fly   356 --RDQFDEEISPKLLEAKCSWWLQYKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMG 418
              |::.::.|..|..||.......| :||.|....:.|||..|.::...|::..|.:......:.
Frog   356 AKRNRKEKLIPFKRKEAPSELSKVY-VLLRRTFRNLSRDKIGIVMRLSQNLIFGLFIAFFLIHLS 419

  Fly   419 TSASKALF--NFGFMFTIVIAYLYLPMMPVLLYFPTEINLLKREYNNQWYRLSSYYAAMVTSKLP 481
            ....|...  ..||::..:.|..|..::..:..|||...:..:|..:..|:......|.:...:|
Frog   420 NDILKGAVQDRLGFIYQCLGAPPYTGLLNAVALFPTLRAIGDQEGKDGLYQKWQMLLAYIIHIVP 484

  Fly   482 SMFILAVIYLSIVYLMSSQPLEWFRFAMLFTIAFVTALTSDSFGLLISSRLSLVNAMFMGP-VLA 545
            ...:..||:...:|.:.....:..||.:.|.:..|..|..:   ||..:.|.:||    .| ::.
Frog   485 FSILSVVIFSGFIYWVIGLYPDILRFGIFFAVILVPHLMGE---LLTLAVLGIVN----NPNIVN 542

  Fly   546 VPLILLSIYGIGYGGGTYIS-----PLMRFLMHLSYLRHSMEGLV 585
            ..:.||:|.||..|.|...|     .:.:.|.:::|.:::.|.||
Frog   543 AGVSLLNIAGILIGSGILRSLQEMPQVFQLLSYITYQKYASELLV 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	78/233 (33%)
		3a01204	67..654	CDD:273361	144/549 (26%)
		ABC2_membrane	381..587	CDD:279410	48/213 (23%)
abcg5	XP_031757398.1	ABCG_White	60..286	CDD:213201	75/227 (33%)
abcg5	XP_031757398.1	3a01204	63..662	CDD:273361	145/556 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920