DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4822 and abcg8

DIOPT Version :9

Sequence 1:	NP_001033861.1	Gene:	CG4822 / 33170	FlyBaseID:	FBgn0031220	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001108041.2	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	684	Species:	Danio rerio

Alignment Length:	686	Identity:	173/686 - (25%)
Similarity:	316/686 - (46%)	Gaps:	81/686 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 STTSQISSLQYSSDINADSLEPDQSEDFQTVLGLKYLPSWPAVNLQFSELC-YVVPDQTNASKTK 73
            |:..:.|||.::.....:.||         |..|.|.....|....:.:|. :.:|.:.:::| :
Zfish    37 SSPEEDSSLYFTYSGGRNELE---------VRNLNYEVDTAAQIPWYEKLSEFKMPWEMHSNK-Q 91

  Fly    74 TILRRVNGMFHSHELTAIIGPSGAGKTTLLNLLA--GFGAVCESGEILVNNSPRDMRVFRKMSRY 136
            |:::.:|...||.::.|:||.||.|||:||:::.  ..|....|||||:|..|....:.:|...:
Zfish    92 TVIKDLNLHVHSGQMLAVIGSSGCGKTSLLDIITCRDEGGSMNSGEILINGKPSTRSLVKKSIAH 156

  Fly   137 IMQTDVLDSQFTVLEMMILAANLKLGKELNLKQKLEVIDEILGMLRLKDTLNT-----MAQKLSG 196
            :.|.|.|....||.|.:...|.|:|....:.||:.:.:|:::..|||:...:|     ..:.:||
Zfish   157 VRQDDRLLPHLTVRETLAFVAKLRLPANFSQKQRDQRVDDVIAELRLRQCAHTRVGNEYVRGVSG 221

  Fly   197 GERKRLCIALELVNNPPVIFLDEPTTGLDDLSSSQCIALLKVLAAGGRTVICSIHTPSAKIFEML 261
            |||:|:.||::|:.||.::.|||||:|||..::...:..|..||.|.|.|:.|:|.|.:.||::.
Zfish   222 GERRRVSIAVQLLWNPGILILDEPTSGLDSFTAHNLVITLYRLARGNRLVLLSVHQPRSDIFQLF 286

  Fly   262 DAVYVLAEGQCVYQGKGSNIVPFLKNFGLCCPITYNPADFII------------EVACLEYGGSY 314
            |.|.:|:.|..||.|:..::|.:....|..||...||:|:.:            |..|||.....
Zfish   287 DLVVLLSSGSAVYCGQAKDMVSYFTTLGYPCPRYCNPSDYYVDLISIDRRTPEKEAQCLEKASML 351

  Fly   315 HEPMVEAVGNGKVARW-----SPPAVEGETTTTKTDT--TSGASSFYERDQFDEEISPKLLEAKC 372
            ....:|.|.|.:...|     .|||:|...::..:.:  .|..:...::||...::.
Zfish   352 AAQFLEKVKNNEDFMWKSEVCGPPALEAPQSSVPSVSMKESVITVSKQKDQLPGKVH-------- 408

  Fly   373 SWWLQYKLLLVRMLIQMWRDKSYIKLKFYMNIVLALLVGSLYFGMGTSASKALFNFGFMFTIVIA 437
                |:..|:.|.:...:||...:.:.....::::||:|.||||....        |......:|
Zfish   409 ----QFTTLIRRQVFNDYRDLVTLVVHGLEALLMSLLIGFLYFGCTEE--------GLSIQDTVA 461

  Fly   438 YLYL--------PMMPVLLYFPTEINLLKREYNNQWYRLSSYYAAMVTSKLPSMFILAVIYLSIV 494
            .||:        .::.|:....:|..:|..|..:..|.::.|:.|.|..:||......::|...:
Zfish   462 LLYMIGALTPFAVVLDVIAKCHSERAMLYHELEDGMYSVTPYFFAKVLGELPEHCAFTLVYGVPI 526

  Fly   495 YLMSSQPLEWFRFAMLFTIAFVTALTSDSFGLLISSRL-SLVNAMFMGPVLAVPLILLSIYGIGY 558
            |.::...:...||.:.|.:.::|...|.|..|.:::.| :|..:.|||..|.....|.:.:.|..
Zfish   527 YWLAGLNVAPDRFLLNFLLVWLTVYCSRSMALFVAAALPTLQTSSFMGNALFTVFYLTAGFVISL 591

  Fly   559 GGGTYISPLMRFLMHLSYLRHSMEGLVASLYDYGRAD-TICEDTEIFCSFKKSKVLLAFLGFENM 622
            .....::   .:..::|::|...||::...:...|.. ||...|..|...|..:::       .|
Zfish   592 ENMWMVA---SWFSYISFMRWGFEGMLQVQFRGTRIPITIGNLTVEFDGIKVVEMM-------KM 646

  Fly   623 HYLWSLSC---LMSFYLLFTVAAYFMIR-LRLKHSE 654
            :.....||   |::..|:|.:..|..:: ::.|.|:
Zfish   647 NQYPLFSCYLVLIAVSLVFILLYYLSLKFIKQKSSQ 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4822	NP_001033861.1	ABCG_EPDR	51..276	CDD:213180	79/232 (34%)
		3a01204	67..654	CDD:273361	160/626 (26%)
		ABC2_membrane	381..587	CDD:279410	46/214 (21%)
abcg8	NP_001108041.2	3a01204	47..674	CDD:273361	167/666 (25%)
		ABCG_White	72..301	CDD:213201	78/229 (34%)
		ABC2_membrane	413..617	CDD:279410	46/214 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574368
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53689
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0000053
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X52
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.860