DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe1 and Slc9b2

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_849208.4	Gene:	Slc9b2 / 97086	MGIID:	2140077	Length:	547	Species:	Mus musculus

Alignment Length:	399	Identity:	77/399 - (19%)
Similarity:	136/399 - (34%)	Gaps:	127/399 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 ASTLVTDPPLI-DSHAVEQEHNSSLSLFFVICVIMLGILLIHSML---QTGFQYLPESIVVVFLG 139
            |..|:.:.|:| ||..::.:.:|||.      .|.|.::|:.:.|   ....:.|....|.:.:|
Mouse   152 AGFLLRNIPVINDSVRIQHKWSSSLR------SIALSVILVRAGLGLDSKALRKLKGVCVRLAMG 210

  Fly   140 AFI------GLSLNVMSGQNGSWKREEVFSPMGFFL----------VLLPPIIF--ESGYNLHKG 186
            ..|      .:..:.:.|....|         ||.|          |::|.::.  |.||.:.||
Mouse   211 PCIVEACASAILSHFLMGLPWQW---------GFILGFVVGAVSPAVVVPSMLLLQEGGYGVGKG 266

  Fly   187 NFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAFRLSFSESFAFGS--------LISAVDP 243
                              |..|::.||.:...|....|......:|:.||        ::..|..
Mouse   267 ------------------IPTLLMAAGSFDDILAITGFNTCLGVAFSTGSTVFNIFRGILEVVIG 313

  Fly   244 VAT-------VAIFHALDVDPIL---NMLVFGESILNDAISIVLTASITQSANVNAEASTGEAMF 298
            ||.       :..|.:.|.|.::   ..||.|                                |
Mouse   314 VAAGSFLGFFIQYFPSRDQDNLVWKRAFLVLG--------------------------------F 346

  Fly   299 SALKTFCAMFFASAGIGVIFALISALL--LKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGI 361
            :.|..|.:::|:..|.|.:..|:.|.|  ::..|.:.    |...::..|:..:
Mouse   347 AVLAVFSSVYFSFPGSGGLCTLVMAFLAGMRWTDKKS----EVEKVIAVTWDVF----------- 396

  Fly   362 MAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKHQVELSFVIW-- 424
            ..:|| |::.:..:..:|...|......|:.....|.....|..:..|.|:.|.::.:||. |
Mouse   397 QPLLF-GLIGAEVSIVSLRAETVGLCVATLSIAVLIRILTTFLMVCFAGFNIKEKIFISFA-WLP 459

  Fly   425 -AIVLCLIG 432
             |.|...||
Mouse   460 KATVQAAIG 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	71/377 (19%)
Slc9b2	NP_849208.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		Na_H_Exchanger	176..534	CDD:382399	69/375 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900