DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and NHX1

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_010744.3	Gene:	NHX1 / 852066	SGDID:	S000002864	Length:	633	Species:	Saccharomyces cerevisiae

Alignment Length:	639	Identity:	191/639 - (29%)
Similarity:	316/639 - (49%)	Gaps:	113/639 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GNASTLVTDPPLIDSHAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAF 141
            |:...:..||. :|.:.|.:|..||.:||.::.:::..:...:.:.|...:.:.|:::.:|.|..
Yeast    38 GSDDPIAGDPD-VDLNPVTEEMFSSWALFIMLLLLISALWSSYYLTQKRIRAVHETVLSIFYGMV 101

  Fly   142 IGLSLNVMSGQNGSWKREEV-FSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTI 205
            |||.:.:..|.   :.::.| |:...||.|||||||..|||.|::.|||.|:.|||:|||.||.|
Yeast   102 IGLIIRMSPGH---YIQDTVTFNSSYFFNVLLPPIILNSGYELNQVNFFNNMLSILIFAIPGTFI 163

  Fly   206 SALVIGAGIYL---LGLGEVAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGES 267
            ||:|||..:|:   |||..:  .:||:::.:.|:.:||.|||..::||:|..|||.|..::||||
Yeast   164 SAVVIGIILYIWTFLGLESI--DISFADAMSVGATLSATDPVTILSIFNAYKVDPKLYTIIFGES 226

  Fly   268 ILNDAISIVLTASITQSANVNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLR 332
            :||||||||:..:..:   .:.:.:|..::|.....|...|..|..|||:..::.||||||..:|
Yeast   227 LLNDAISIVMFETCQK---FHGQPATFSSVFEGAGLFLMTFSVSLLIGVLIGILVALLLKHTHIR 288

  Fly   333 KHPSLEFAMMLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFI 397
            ::|.:|..::|:..|..|..:.|.|:|||:::|||||.:.||.::|:|..:|||::...:.||.:
Yeast   289 RYPQIESCLILLIAYESYFFSNGCHMSGIVSLLFCGITLKHYAYYNMSRRSQITIKYIFQLLARL 353

  Fly   398 AETCVFAYLGLAIFSFKHQVELSF-----VIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKM- 456
            :|..:|.||||.:|:   :|||.:     ::.||.:| :.|.|.:|||:..||.....|....|
Yeast   354 SENFIFIYLGLELFT---EVELVYKPLLIIVAAISIC-VARWCAVFPLSQFVNWIYRVKTIRSMS 414

  Fly   457 -----------------QFIMWFSGLRGAISYALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLG 504
                             |.:.:::|||||:..||:|.:   ..|.:..::.|.|::|:.|.::.|
Yeast   415 GITGENISVPDEIPYNYQMMTFWAGLRGAVGVALALGI---QGEYKFTLLATVLVVVVLTVIIFG 476

  Fly   505 GSTMPLLKYL--KPGKKRRARGSGRNAAEEGGRR----NG------------------------- 538
            |:|..:|:.|  |.|.......|......|..|.    ||
Yeast   477 GTTAGMLEVLNIKTGCISEEDTSDDEFDIEAPRAINLLNGSSIQTDLGPYSDNNSPDISIDQFAV 541

  Fly   539 -SGRKRSKSISLSKTREWGQAIDSEHLSELTEEEDVTFTQARDRFGRMDRKYFIPFFTRRFNSQE 602
             |.:....:||.:....:|...::|:.|.......:.....||:.|.:            |||.
Yeast   542 SSNKNLPNNISTTGGNTFGGLNETENTSPNPARSSMDKRNLRDKLGTI------------FNSD- 593

  Fly   603 LHECKSQMADLTNKWYQAI-----------RVSPLDSDESDEEIGLAASTSQIH 645
                        ::|:|..           .|||...|.:.:  ..|..:||.|
Yeast   594 ------------SQWFQNFDEQVLKPVFLDNVSPSLQDSATQ--SPADFSSQNH 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	156/443 (35%)
NHX1	NP_010744.3	b_cpa1	55..611	CDD:273294	178/595 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I341
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I614
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55694
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46644
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770