DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and NHX3

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_200358.1	Gene:	NHX3 / 835640	AraportID:	AT5G55470	Length:	529	Species:	Arabidopsis thaliana

Alignment Length:	537	Identity:	176/537 - (32%)
Similarity:	274/537 - (51%)	Gaps:	55/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 EHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMSGQNGSWKREEV 161
            ||...:.:...|.::.|.:::.|.:.:.  :::.|||..:.:||..|..:.::|  .|......|
plant    16 EHPQVIPISVFIAILCLCLVIGHLLEEN--RWVNESITAILVGAASGTVILLIS--KGKSSHILV 76

  Fly   162 FSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAFR- 225
            |....||:.|||||||.:|:.:.|..||.|..:|:.|.:.|..||.::|..|.:.| ..::.|:
plant    77 FDEELFFIYLLPPIIFNAGFQVKKKKFFHNFLTIMSFGVIGVFISTVIISFGTWWL-FPKLGFKG 140

  Fly   226 LSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSANVNAE 290
            ||..:..|.|::.|:.|.|.|:.|.|. |..|:|..|||||.::|||.|:||..::.:   :..|
plant   141 LSARDYLAIGTIFSSTDTVCTLQILHQ-DETPLLYSLVFGEGVVNDATSVVLFNAVQK---IQFE 201

  Fly   291 ASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSL-EFAMMLMFTYAPYVLAE 354
            :.||.........|..:|..|..:|:...||::.:||.:...:|.:. |.|:|::..|..|:|||
plant   202 SLTGWTALQVFGNFLYLFSTSTLLGIGVGLITSFVLKTLYFGRHSTTRELAIMVLMAYLSYMLAE 266

  Fly   355 GIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLG----------LA 409
            ...||||:.:.|||::||||..:|::..::||.:.....|:|||||.:|.|:|          .:
plant   267 LFSLSGILTVFFCGVLMSHYASYNVTESSRITSRHVFAMLSFIAETFIFLYVGTDALDFTKWKTS 331

  Fly   410 IFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINN-----KMQFIMWFSGL-RGA 468
            ..||...:.:|.||.|:|  |:|||..:|||:.|.|....|...|     |.|.|:|::|| |||
plant   332 SLSFGGTLGVSGVITALV--LLGRAAFVFPLSVLTNFMNRHTERNESITFKHQVIIWWAGLMRGA 394

  Fly   469 ISYALSLH------LNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGR 527
            :|.||:..      :.||....  .::|.|.|:|||||||.|..|.||:.||.|      :.:..
plant   395 VSIALAFKQFTYSGVTLDPVNA--AMVTNTTIVVLFTTLVFGFLTKPLVNYLLP------QDASH 451

  Fly   528 NAAEEGGRRNGSGRKRSKSISL-----SKTREWGQAIDSEHLSELTEEEDVTFTQARDRFGRMDR 587
            |....|.|......|...::.|     |.:..:.:|.||  :|.|.|:...|..:...:|   |.
plant   452 NTGNRGKRTEPGSPKEDATLPLLSFDESASTNFNRAKDS--ISLLMEQPVYTIHRYWRKF---DD 511

  Fly   588 KYFIPFF--TRRFNSQE 602
            .|..|.|  .||.|..|
plant   512 TYMRPIFGGPRRENQPE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	150/438 (34%)
NHX3	NP_200358.1	b_cpa1	23..>444	CDD:273294	149/433 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55694
OrthoDB	1	1.010	-	-		D546232at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.890