DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and Slc9a8

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	XP_036018592.1	Gene:	Slc9a8 / 77031	MGIID:	1924281	Length:	604	Species:	Mus musculus

Alignment Length:	579	Identity:	317/579 - (54%)
Similarity:	393/579 - (67%)	Gaps:	56/579 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SNTTTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNASTLVTDPPL-------IDSH 92
            ||||....:.::||...|                    |||      ||...|.       ....
Mouse     7 SNTTHETFNFTLHTTLGV--------------------TTK------LVLPTPAKPILPVQTGEQ 45

  Fly    93 AVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFIGLSLNVMSGQN-GSW 156
            |.::|.:|.:::||.:.|:.:.|:|:|.:::....:||||:.||.||..:|..:.|:..:. .:|
Mouse    46 AQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKVIEFKKLANW 110

  Fly   157 KREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGE 221
            |.||:|.|..|||:|||||||||||:|||||||||||||.:||:|||.|||.|:|.|||.||..:
Mouse   111 KEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD 175

  Fly   222 VAFRLSFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVLTASITQSAN 286
            |..:|:.::||||||||||||||||:|||:||.|||:||||||||||||||:|||||.:......
Mouse   176 VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTR 240

  Fly   287 VNAEASTGEAMFS-ALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYAPY 350
            .:....:|...|| ||..|..|||.||.:|.:..|||||:||||||||.|||||.||::|.|.||
Mouse   241 KHMSDVSGWQTFSQALGYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPY 305

  Fly   351 VLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYLGLAIFSFKH 415
            .|||||.|||||||||.|||||||||.|||.||||.||||:||:||:.||||||:|||:||||.|
Mouse   306 GLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPH 370

  Fly   416 QVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAISYALSLHLNLD 480
            :.|:|||||.|||.|.|||.|||||::|:|.||:|||..||.||||||||||||.|||||||.|:
Mouse   371 KFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLGLE 435

  Fly   481 SQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGRRNGSGRKRSK 545
            ..|||.:|.|||::|||||.|:||||||||:: |...:..|||                 |:..|
Mouse   436 PMEKRQLIGTTTIVIVLFTILLLGGSTMPLIR-LVDIEDARAR-----------------RRSKK 482

  Fly   546 SISLSKTREWGQAIDSEHLSELTEEE-DVTFTQARDRFGRM--DRKYFIPFFTRRFNSQ 601
            .::||||.:.|.||:||||||||||| :..:.:.:|..|.|  |.||..||||||...:
Mouse   483 DVNLSKTEKMGNAIESEHLSELTEEEYEAHYIRQQDLKGFMWLDAKYLNPFFTRRLTQE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	266/416 (64%)
Slc9a8	XP_036018592.1	b_cpa1	59..>483	CDD:273294	269/441 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849607
Domainoid	1	1.000	510	1.000	Domainoid score	I325
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75041
Inparanoid	1	1.050	600	1.000	Inparanoid score	I943
Isobase	1	0.950	-	0	Normalized mean entropy	S1854
OMA	1	1.010	-	-		QHG55694
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006247
OrthoInspector	1	1.000	-	-		oto93896
orthoMCL	1	0.900	-	-		OOG6_100371
Panther	1	1.100	-	-	LDO	PTHR10110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3118
SonicParanoid	1	1.000	-	-		X3978
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740