DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and Slc9b1

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_083222.2	Gene:	Slc9b1 / 74446	MGIID:	1921696	Length:	565	Species:	Mus musculus

Alignment Length:	414	Identity:	91/414 - (21%)
Similarity:	145/414 - (35%)	Gaps:	145/414 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 GFQYLPE----SIVVVFLGAFIGLSLNVMSGQNGSWKREEVFSP--------MGFFLVLLPPIIF 177
            |.:.||.    .:||:|..||:|       |:...:.|..|..|        :..|.:...|||:
Mouse   137 GQEVLPGGNLFGLVVIFYSAFLG-------GKILEFIRIPVVPPLPPLIGMLLAGFTIRNVPIIY 194

  Fly   178 ESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGI-----YLLGLGEVAFRLSFSE------- 230
            |          |.:|.:....|:..|.::.:::.||:     .|..|..|..||||..
Mouse   195 E----------FVHIPTTWSSALRNTALTIILVRAGLGLDPQALKHLKGVCLRLSFGPCFLEACS 249

  Fly   231 ---------------SFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGES--ILNDAISIVLT 278
                           .|..|.::.||.|...|.           |||:..|:  .:...|..:|.
Mouse   250 AALFSHFIMNFPWQWGFLLGFVLGAVSPAVVVP-----------NMLMLQENGYGVEKGIPTLLV 303

  Fly   279 ASITQSANVNAEASTGEAMFSALKTFCAMFFASAG-------------IGVIFAL---------- 320
            |:   |:..:..|.||      ..||.::.|:|..             |||:..:
Mouse   304 AA---SSMDDIVAITG------FNTFLSIVFSSGSVISNILSSLRDVLIGVLVGIVMGVFVQYFP 359

  Fly   321 -------------------ISALL-LKHIDLRKHPSLEFAMMLMFTYAPYVLAEGIHLSGIMA-- 363
                               |||:| .:||.|.....| ..::|.|..|.....|.:.:..|:|
Mouse   360 SGDQERLTQRRAFLVLSMCISAVLGCQHIGLHGSGGL-VTLVLSFMAAKRWAEEKVGIQKIVANT 423

  Fly   364 ------ILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCV---FAYLGLAIFSFKHQV-- 417
                  :|| |:|   .|..::.::...|:...:.||.......:   |..:..|.|.||.:|
Mouse   424 WNVFQPLLF-GLV---GTEVSVESLESKTIGMCLATLGLALSVRILSTFVLMSFANFRFKEKVFI 484

  Fly   418 ELSFVIWAIVLCLIGRACNIFPLA 441
            .||::..|.|..::|      |||
Mouse   485 ALSWIPKATVQAVLG------PLA 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	91/414 (22%)
Slc9b1	NP_083222.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..112
Slc9b1	NP_083222.2	Na_H_Exchanger	207..551	CDD:382399	70/327 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810