DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe1 and SLC9A5

DIOPT Version :9

Sequence 1:	NP_608491.3	Gene:	Nhe1 / 33167	FlyBaseID:	FBgn0026787	Length:	649	Species:	Drosophila melanogaster
Sequence 2:	NP_004585.1	Gene:	SLC9A5 / 6553	HGNCID:	11078	Length:	896	Species:	Homo sapiens

Alignment Length:	539	Identity:	166/539 - (30%)
Similarity:	269/539 - (49%)	Gaps:	70/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 HAVEQEHNSSLSLFFVICVIMLGILLIHSMLQTGFQYLPESIVVVFLGAFI-GLSLNVMSGQNGS 155
            |.||..:..:|    .|.|..|..::.| :.:.....:|||.:::.||..: |:.|.|..
Human    42 HEVEAPYLVAL----WILVASLAKIVFH-LSRKVTSLVPESCLLILLGLVLGGIVLAVAK----- 96

  Fly   156 WKREEVFSPMGFFLVLLPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIY-LLGL 219
             |.|....|..|||.|||||:.:|||.:....||.|:|:||.:|:.||..:|...||.:: |...
Human    97 -KAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQA 160

  Fly   220 GEVAFRL--SFSESFAFGSLISAVDPVATVAIFHALDVDPILNMLVFGESILNDAISIVL---TA 279
            |.||.|:  ...:...||||||||||||.:|:|..:.|:..|.::|||||:||||:::||   ..
Human   161 GLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCN 225

  Fly   280 SITQSANVNAEASTGEAMFSALKTFCAMFFASAG---IGVIFALISALLLKHIDLRKHPSLEFAM 341
            |..:..:.|.:|:      ..||...::|..|.|   :|::||.:.||..:.  .::...:|..:
Human   226 SFVEMGSANVQAT------DYLKGVASLFVVSLGGAAVGLVFAFLLALTTRF--TKRVRIIEPLL 282

  Fly   342 MLMFTYAPYVLAEGIHLSGIMAILFCGIVMSHYTHFNLSTVTQITMQQTMRTLAFIAETCVFAYL 406
            :.:..||.|:.||...||.|:|:..||:....|...|:|..::.|::.||:|||..|||.:|..|
Human   283 VFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLL 347

  Fly   407 GL-AIFSFKHQVELSFVIWAIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSGLRGAIS 470
            |: |:.|.|...:...|:..::..|..||..:....:::|:||...::...|.:|.:.|||||::
Human   348 GISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVA 412

  Fly   471 YALSLHLNLDSQEKRHVIITTTLIIVLFTTLVLGGSTMPLLKYLKPGKKRRARGSGRNAAEEGGR 535
            :||.:.|:......:...:.||:::|.||.:|.|.:..||:|:||.
Human   413 FALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKV------------------- 458

  Fly   536 RNGSGRKRSKSISLSKTREWGQAIDSEHLSE--LTEEEDVT----FTQARDRFGRMDRKYFIPFF 594
                  |||:....:..:|.     .||..:  |...|||.    :...|||:.:.|:||.....
Human   459 ------KRSEHHKPTLNQEL-----HEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLL 512

  Fly   595 TRRFNSQELHECKSQMADL 613
            .||    ..:..:.|:.|:
Human   513 MRR----SAYRIRDQIWDV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe1	NP_608491.3	NhaP	100..515	CDD:223104	141/425 (33%)
SLC9A5	NP_004585.1	NhaP2	41..630	CDD:330436	166/539 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..686
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810